Acinar Cell-Derived Extracellular Vesicle MiRNA-183-5p Aggravates Acute Pancreatitis by Promoting M1 Macrophage Polarization Through Downregulation of FoxO1.

Acute pancreatitis (AP) is a common cause of a clinically acute abdomen. Crosstalk between acinar cells and leukocytes (especially macrophages) plays an important role in the development of AP. However, the mechanism mediating the interaction between acinar cells and macrophages is still unclear.

Comprehensive Analysis of Necroptosis in Pancreatic Cancer for Appealing its Implications in Prognosis, Immunotherapy, and Chemotherapy Responses.

Necroptosis represents a new target for cancer immunotherapy and is considered a form of cell death that overcomes apoptosis resistance and enhances tumor immunogenicity. Herein, we aimed to determine necroptosis subtypes and investigate the roles of necroptosis in pancreatic cancer therapy. Based on the expression of prognostic necroptosis genes in pancreatic cancer samples from TCGA and ICGC cohorts, a consensus clustering approach was implemented for robustly identifying necroptosis subtypes.

ATG7-enhanced impaired autophagy exacerbates acute pancreatitis by promoting regulated necrosis via the miR-30b-5p/CAMKII pathway.

The present study was performed to explore whether and how impaired autophagy could modulate calcium/calmodulin-dependent protein kinase II (CAMKII)-regulated necrosis in the pathogenesis of acute pancreatitis (AP). Wistar rats and AR42J cells were used for AP modeling. When indicated, genetic regulation of CAMKII or ATG7 was performed prior to AP induction.

lncRNA FGD5‑AS1 promotes breast cancer progression by regulating the hsa‑miR‑195‑5p/NUAK2 axis.

Breast cancer is the second most prevalent cancer in women worldwide. Long non‑coding RNAs (lncRNAs) have been identified as important regulators of tumorigenesis and tumor metastasis. lncRNA FGD5‑AS1 has been previously reported as a carcinogenic gene, however its role in breast cancer has yet to be investigated.

Correction: Lanthanide separation using size-selective crystallization of Ln-MOFs.

Correction for 'Lanthanide separation using size-selective crystallization of Ln-MOFs' by Heng Ya Gao et al., Chem. Commun.

Lanthanide separation using size-selective crystallization of Ln-MOFs.

Herein, we report an elaborate method, size-selective crystallization of Ln-MOFs, to isolate lanthanide (Ln) ions. Herein, 13 lanthanide ions, except for the radioactive Pm(iii) ion, were separated by four types of Ln-MOFs: type I (La-Pr), type II (Nd-Eu), type III (Gd-Ho), and type IV (Er-Lu). Further systemic investigation also suggested the highly selective separation of lanthanide ions by this method.

Photoswitching adsorption selectivity in a diarylethene-azobenzene MOF.

The first MOF (metal-organic framework) built on both diarylethene and azobenzene photochromic units is reported here and displays distinct photoresponses for different guest molecules, thus creating an easy-to-use pathway to modulate the adsorption selectivity of MOF materials.

Reversible photo/thermoswitchable dual-color fluorescence through single-crystal-to-single-crystal transformation.

Reversible photo/thermoswitchable dual-color green-to-blue fluorescence is reported here, which is mainly due to a single-crystal-to-single-crystal (SCSC) transformation of the chromophore from a supramolecular aggregation to a covalently bonded polymer.

MOF catalysis of Fe(II)-to-Fe(III) reaction for an ultrafast and one-step generation of the Fe2O3@MOF composite and uranium(vi) reduction by iron(ii) under ambient conditions.

Herein, we demonstrate that Zn-MOF-74 enables the ultrafast and one-step generation of the Fe2O3@MOF composite once Zn-MOF-74 contacts with FeSO4 solution. This unique reaction can be further applied in catalysis of U(vi) reduction by Fe(ii) under ambient conditions. The results provide a highly renovated strategy for U(vi) reduction by Fe(ii) just under ambient conditions, which completely subvert all established methods about U(vi) reduction by Fe(ii) in which O2- and CO2-free conditions are absolutely required.