Long-Term Disease Control and Minimal Disease Activity of Head and Neck Atopic Dermatitis in Patients Treated with Tralokinumab up to 4 Years.

Background And Objective: There is a need for long-term atopic dermatitis (AD) treatments that can effectively improve AD involvement of the head and neck (H&N) region (referred to as H&N AD). Tralokinumab, a high-affinity monoclonal antibody that neutralizes interleukin-13, is approved for the treatment of moderate-to-severe AD. Recent real-world studies have observed the effectiveness of tralokinumab for H&N AD.

SIRT2 Regulates Apoptosis Signaling in Hyperoxic Acute Lung Injury.

Purpose: Oxygen therapy is helpful for patients with breathing difficulties; however, sustained supplementation with high-concentration oxygen can cause hyperoxic acute lung injury. Sirtuin 2 (SIRT2), a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase, has been shown to be involved in pulmonary fibrosis, apoptosis, and inflammation. Here, we elucidated the role of SIRT2 in hyperoxic acute lung injury.

Leveraging AlphaFold models to predict androgenic effects of endocrine-disrupting chemicals through zebrafish androgen receptor analysis.

The androgen receptor (AR) activation by androgens is vital for tissue development, sexual differentiation, and reproductive attributes in zebrafish (). However, our understanding of the molecular mechanisms behind their activation remains limited. In this study, we employed both (AlphaFold) and homology (SWISS-MODEL) structure models of zebrafish androgen receptor ligand-binding domain (zAR-LBD) to explore the binding specificity, binding affinity, and molecular interactions of endogenous hormones (testosterone (T), 11-ketotestosterone (11-KT), and dihydrotestosterone (DHT)) in a computational simulation.

Association of Handgrip Strength With Readmission, Mortality, and Exercise Capacity in Patients With Heart Failure.

Background: Patients with heart failure (HF) experience a marked reduction in overall skeletal muscle strength and exercise capacity, which is detrimental to their prognosis. This study examined the clinical implications of handgrip strength (HGS) in patients with HF.

Methods: Overall, 173 patients (mean age, 62 years; 81.

AI Applications for Thoracic Imaging: Considerations for Best Practice.

Artificial intelligence (AI) technology is rapidly being introduced into thoracic radiology practice. Current representative use cases for AI in thoracic imaging show cumulative evidence of effectiveness. These include AI assistance for reading chest radiographs and low-dose (1.

Fluoride-rich Sulfide Solid Electrolyte With Ultrahigh Air Stability for All-Solid-State Batteries.

Argyrodites are among the most promising sulfide-based solid electrolytes (SEs) due to their high ionic conductivity and ductility. However, the poor atmospheric stability of sulfide-based SEs caused by the side reaction with moisture, which generates toxic HS gas and degrades its high ionic conductivity and low electronic conductivity, has limited the commercialization of ASSBs. Herein, the preparation of sulfide-based SEs consisting of a LiPSCl (LPSCl) core and fluoride-rich LPSCl shell are described using a facial fluorine treatment following an annealing process to improve atmospheric stability.

Sex-specific effects of apolipoprotein E ε4 genotype on longitudinal hippocampal atrophy in amnestic mild cognitive impairment over a 2-year evaluation period.

Background: Hippocampal atrophy is implicated in the early onset of Alzheimer's disease (AD). It is closely associated with rapid cognitive decline and serves as a critical predictor for conversion from mild cognitive impairment (MCI) to AD. Consequently, with growing interest in utilizing hippocampal volume (HV) as an outcome measure in clinical trials, elucidating the neurobiological mechanisms underlying hippocampal atrophy is essential for early diagnosing AD and predicting its progression.

Patient-Provider Prenatal Nutrition Conversations Using a Human Factors Approach.

Objective: To examine patient-provider nutrition conversations at initial prenatal visits.

Design: Convergent mixed methods observational study.

Setting: Two large metropolitan clinics in the midwestern United States.

A Multi-Center, Prospective, Observational Study to Evaluate the Therapeutic Effectiveness and Safety of an Olmesartan/Amlodipine Plus Rosuvastatin Combination Treatment in Patients with Concomitant Hypertension and Dyslipidemia.

This study assessed the therapeutic effectiveness of a single-pill combination (SPC) of olmesartan/amlodipine plus rosuvastatin for blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) in patients with hypertension and dyslipidemia. Adult patients with hypertension and dyslipidemia who were decided to be treated with the study drug were eligible. The primary endpoint was the proportion of patients who achieved BP, LDL-C and both BP and LDL-C treatment goals at weeks 24-48.

Phase angle in bioelectrical impedance analysis for assessing congestion in acute heart failure.

Background: The phase angle (PhA) in bioelectrical impedance analysis (BIA) reflects the cell membrane integrity or body fluid equilibrium. We examined how the PhA aligns with previously known markers of acute heart failure (HF) and assessed its value as a screening tool.

Methods: PhA was measured in 50 patients with HF and 20 non-HF controls along with the edema index (EI), another BIA parameter suggestive of edema.

Cost burden of productivity loss due to sickness presenteeism among nurses in South Korea: A cross-sectional study.

Aim: This study aimed to estimate the annual cost burden of productivity loss due to sickness presenteeism among hospital nurses in South Korea.

Background: Despite nurses being potentially more vulnerable to presenteeism, few studies have analyzed nurses' productivity losses due to sickness presenteeism.

Methods: This cross-sectional study employed an online survey in January 2023 with 607 nurses working in general/tertiary hospitals in South Korea.

Impact of Concomitant Injuries on Clinical Outcomes in Patients with Isolated versus Non-Isolated Traumatic Brain Injury.

Objective: Traumatic brain injury (TBI) often occurs alongside injuries to other body regions, worsening patient outcomes. This study aimed to evaluate the impact of concomitant injuries on clinical outcomes in patients with isolated versus non-isolated TBI.

Method: A retrospective cross-sectional analysis was conducted using data from the Emergency Department-based Injury In-depth Surveillance System (EDIIS), encompassing 180,058 TBI patients admitted to 23 tertiary hospitals from January 1, 2020, to December 31, 2022.

Synthesis of zirconium-based metal-organic framework/gelatin aerogel for removing phosphate and fluoride from aqueous solutions.

This study describes the preparation of novel hybrid aerogels derived from gelatin (Gel), incorporating Br-functionalized zirconium-based metal-organic framework (UiO-66-Br; MOF) as modifying agent to effectively eliminate phosphate and fluoride ions from aqueous environments. The adsorption performance of MOF decorated Gel (Gel-xMOF) hybrid aerogels was investigated under different conditions, including agitation time, adsorbent dosage, solution pH, initial phosphate and fluoride concentrations, coexisting ions, and temperature. The functional groups of the gelatin network, coupled with UiO-66-Br, enhanced the adsorption performance of phosphate and fluoride ions from aqueous solutions.

Efficient photo-assisted activation of peroxydisulfate by a novel Z-scheme sulfur-doped CN/DyFeO heterojunction for norfloxacin degradation: Activation mechanism and DFT studies on reaction pathways.

Peroxydisulfate (PDS) activation is a crucial process for wastewater treatment in complicated water matrices. However, it is frequently limited because of poor selectivity, sluggish kinetics, and short lifetime of radicals. Therefore, in this study, an efficient sulfur-doped CN/DyFeO (SCN/DyF) Z-scheme heterostructure catalyst was rationally developed using a simple wet-chemical strategy to photoactivate PDS, which can effectively degrade norfloxacin (NOR; 96.

A Network Analysis of Quality of Life Among Older Adults With Arthritis.

Introduction: Arthritis, one of the most common chronic diseases among older people, greatly impairs quality of life through a variety of physical and psychological challenges. This study used network analysis to gain a deeper understanding of the relationships between the indicators of quality of life in older adults with arthritis depending on duration of disease.

Methods: This cross-sectional study used data from 874 older adults with osteoarthritis and/or rheumatoid arthritis who answered the eighth (2019-2021) Korea National Health and Nutrition Examination Survey.

Ionic Diode-Based Drug Delivery System.

Drug delivery systems hold promise for delivering cytotoxic drugs by controlling the timing and location of the drug release. However, conventional delivery mechanisms often fall short of achieving spatiotemporally controlled yet sustained release, which is crucial for ensuring drug efficacy and minimizing impact on surrounding tissues. Here, an ionic diode-based drug delivery system is reported that is controlled by an electric potential and capable of releasing drugs at scales ranging from nanogram to microgram.

Coronary vasomotor response incidence to intracoronary acetylcholine provocation test according to the severity of insignificant coronary artery stenosis in Korean population.

Background: Coronary artery spasm (CAS) is a cause of variant angina. However, the understanding of CAS patterns in the presence of mild-to-moderate coronary artery stenosis is limited. This study aimed to evaluate the incidence and patterns of CAS in patients with insignificant coronary artery stenosis using intracoronary acetylcholine (ACH) provocation test.

Non-Pharmacological Sleep Interventions after Cardiac Surgery: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Aim: To synthesise up-to-date research evidence for non-pharmacological interventions to improve various sleep outcomes (e.g., sleep quality, duration) in postsurgical cardiac patients.

Biomarkers for Short-Term Omalizumab Response in Chronic Spontaneous Urticaria.

Background: Omalizumab, a monoclonal antibody targeting immunoglobulin E (IgE), is approved for adults and adolescents (12 years or older) with chronic spontaneous urticaria (CSU) that does not respond to high-dose antihistamines. In Korea, there is limited research on predictive biomarkers for omalizumab response in CSU patients.

Objective: This retrospective, single-institution study aimed to identify clinical parameters predicting omalizumab response in Korean CSU patients.

Elucidation and engineering of Sphingolipid biosynthesis pathway in Yarrowia lipolytica for enhanced production of human-type sphingoid bases and glucosylceramides.

Sphingolipids are vital membrane components in in mammalian cells, plants, and various microbes. We aimed to explore and exploit the sphingolipid biosynthesis pathways in an oleaginous and dimorphic yeast Yarrowia lipolytica by constructing and characterizing mutant strains with specific gene deletions and integrating exogenous genes to enhance the production of long-chain bases (LCBs) and glucosylceramides (GlcCers). To block the fungal/plant-specific phytosphingosine (PHS) pathway, we deleted the SUR2 gene encoding a sphinganine C4-hydroxylase, resulting in a remarkably elevated secretory production of dihydrosphingosine (DHS) and sphingosine (So) without acetylation.

How Acculturation Shapes Sleep in Thai Women in the United States During Menopausal Transition: A Mediation and Moderation Analysis.

Introduction: This study examines acculturation's impact on sleep quality, efficiency, and obstructive sleep apnea (OSA) risk among Thai women in the United States transitioning through menopause.

Methodology: This cross-sectional descriptive study recruited 120 Thai women aged 40 to 65. Questionnaires assessed sleep quality (Pittsburgh Sleep Quality Index [PSQI]), OSA risk (Berlin), menopausal symptoms (Menopause Rating), acculturation (Suinn-Lew Asian Self-Identity Scale), and anxiety (Patient-Reported Outcome Measurement Information System).

Fatigue and Sleep-related Impairment as Predictors of the Effect of Nonpharmacological Therapies for Active duty Service Members With Chronic Pain: A Secondary Analysis of a Pragmatic Randomized Clinical Trial.

Introduction: First-line treatments for chronic pain include selected complementary and integrative health therapies, including spinal manipulation, acupuncture, yoga, and massage; and standard rehabilitative care, including physical and occupational therapies. This study aimed to uncover critical factors that contribute to pain impact and the effectiveness of complementary and integrative health therapies and standard rehabilitative care among people with chronic pain, with a focus on the role of sleep-related impairment.

Materials And Methods: We conducted a secondary analysis of data from a pragmatic randomized clinical trial of 280 U.

Dendritome Mapping Unveils Spatial Organization of Striatal D1/D2-Neuron Morphology.

Morphology is a cardinal feature of a neuron that mediates its functions, but profiling neuronal morphologies at scale remains a formidable challenge. Here we describe a generalizable pipeline for large-scale brainwide study of dendritic morphology of genetically-defined single neurons in the mouse brain. We generated a dataset of 3,762 3D-reconstructed and reference-atlas mapped striatal D1- and D2- medium spiny neurons (MSNs).