Publications by authors named "Chang O"

Background: Child maltreatment is a public health concern associated with increased youth internalizing symptoms. School connectedness has been shown to play a protective role in the relationship between child maltreatment and externalizing symptoms; yet, its protective role on internalizing symptoms for youth in different racial/ethnic subgroups remains underexplored.

Objective: This study aimed to examine whether school connectedness buffers the effect of child maltreatment on internalizing symptoms for White, Black, Latino/Hispanic, and multiracial youth.

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Background: Interest in uterine-sparing procedures has increased due to the potential for lower blood loss and shorter operative time. Surgical efficacy of hysteropexy relative to traditional hysterectomy-based prolapse procedure remains uncertain over the long-term.

Objectives: The objective of our study was to determine if there is a difference in the rate of surgical retreatment for prolapse after native-tissue apical prolapse surgery with hysterectomy versus uterine-preservation.

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Background: Child maltreatment is a significant public health concern in the United States, with long-lasting consequences for children's development. Exposure to community violence is a known risk factor for child maltreatment, yet the mechanisms underlying this relationship are unclear. Self-efficacy, a construct reflecting an individual's perceived ability to influence their environment, may play a critical mediating role in this pathway.

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Testing of candidate monoclonal antibody therapeutics in preclinical models is an essential step in drug development. Identification of antibody therapeutic candidates that bind their human targets and cross-react to mouse orthologs is often challenging, especially for targets with low sequence homology. In such cases, surrogate antibodies that bind mouse orthologs must be used.

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Importance: Restrictive physical activity after pelvic reconstructive surgery is recommended, although the optimal duration and intensity are not standardized.

Objective: This systematic review and meta-analysis aimed to evaluate the existing literature comparing clinical outcomes for liberal postoperative physical activity versus standard of care, defined as restricted postoperative physical activity, after pelvic reconstructive surgery.

Study Design: PubMed, CENTRAL, Scopus, Web of Science, and CINAHL databases were searched for observational and randomized studies comparing liberal postoperative physical activity and standard of care in women undergoing pelvic reconstructive surgery, reporting anatomic and functional outcomes.

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Background: Each year 1.5 million children receive childcare subsidized under the Child Care and Development Fund, which supports working parents with low income in affording childcare; such policies hold promise for reducing child neglect.

Objective: The current study sought to examine how receiving childcare subsidies might reduce emotional neglect by supporting working parents' self-efficacy.

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Article Synopsis
  • The study investigated how neighborhood factors linked to child maltreatment in urban areas also impact rural areas, using child welfare data from Michigan.
  • Researchers employed factor analysis to explore relationships between economic disadvantage, residential instability, and childcare burden in both metro and nonmetro census tracts.
  • Results indicated some similarities in factors affecting child maltreatment, like neighborhood poverty and single-parent households, while also highlighting unique aspects in rural areas that need further exploration.
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Objective: Statements such as the Bridgetown Declaration serve as a wake-up call for action to address the significant mental health needs in small island developing states. Overarching frameworks and action plans have been developed to support nations to promote mental health and build resilience for their populations in the region, and while these frameworks and action plans provide direction, translating them into grassroots change can be a challenge. At the Creating Futures 23 conference, delegates from the Oceania region were invited to participate in a plenary workshop entitled Framing the Future.

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Purpose Of Review: The ideal graft material for the augmentation of pelvic organ prolapse (POP) has yet to be discovered. While synthetic mesh offers durable repairs this can be at the expense of mesh complications. Biologic grafts have been considered an alternative.

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Article Synopsis
  • The study aimed to evaluate the effectiveness and safety of corticosteroids in treating pediatric sepsis and septic shock by reviewing multiple databases and clinical trials up to September 2023.
  • A total of 16 randomized controlled trials involving 973 patients were analyzed, indicating that corticosteroid treatment might lower mortality rates, reduce hospital stays, and decrease time spent in pediatric intensive care.
  • Although corticosteroids were linked to a risk of gastrointestinal bleeding, they did not show a higher risk of secondary infections, and the quality of the evidence was rated as low to very low.
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Objectives: To review the challenges to developing and sustaining the Pacific mental health workforce for future planning.

Conclusion: Emerging from a colonial mental health service and training paradigm, contemporary Pacific Island Countries and Territories confront significant workforce education and training challenges that require solutions relevant to regional circumstances.

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Emotions play an important role in fostering positive parenting and healthy child development. This qualitative study explored the affective experiences of racially diverse US fathers with low income across the prenatal, postnatal, and early childhood periods. Semi-structured interviews were conducted with 24 fathers.

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Article Synopsis
  • Deep learning enhances computer-aided diagnosis systems by utilizing pathologists' viewing patterns through generated heatmaps, guiding training without needing individual case annotations.
  • The proposed model, a U-Net with a pre-trained ResNet-18 encoder, significantly outperforms traditional methods in detecting areas of interest in melanoma diagnosis, achieving higher precision, recall, F1-score, and Intersection over Union.
  • Clinical evaluations by dermatopathologists confirm the model's effectiveness in mimicking diagnostic behavior and accurately pinpointing critical regions, demonstrating that heatmaps can improve diagnostic accuracy, streamline annotations, and support training for new pathologists.
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Importance: Child physical and emotional abuse and neglect may affect epigenetic signatures of accelerated aging several years after the exposure.

Objective: To examine the longitudinal outcomes of early-childhood and midchildhood exposures to maltreatment on later childhood and adolescent profiles of epigenetic accelerated aging.

Design, Setting, And Participants: This cohort study used data from the Future of Families and Child Wellbeing Study (enrolled 1998-2000), a US birth cohort study with available DNA methylation (DNAm) data at ages 9 and 15 years (assayed between 2017 and 2020) and phenotypic data at birth (wave 1), and ages 3 (wave 3), 5 (wave 4), 9 (wave 5), and 15 (wave 6) years.

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Importance: The genital hiatus (GH) has been identified as a predictor of pelvic organ prolapse. An enlarged preoperative GH is a risk factor for recurrent prolapse after surgery.

Objective: The objective of this study was to determine the changes in preoperative and postoperative GH size compared with the intraoperative resting GH at 6 weeks and 12 months after native-tissue pelvic organ prolapse surgery.

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Early in the COVID-19 pandemic, studies documented a marked decline in mental health and well-being when compared with prepandemic levels. This study examined how different coping styles were associated with anxiety, depression, and sleep problems among U.S.

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Objective: Higher than expected rates of mental health and/or addiction (MHA) concerns have been documented since the onset of the COVID-19 pandemic. A more up-to-date prevalence of MHA outcomes and the factors associated with the occurrence of MHA concerns remains unclear. This study examined the prevalence of MHA outcomes and factors associated with screening positive for symptoms of depression only, anxiety only, and both depression and anxiety two years into the COVID-19 pandemic in Ontario, Canada.

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Article Synopsis
  • Human papillomavirus (HPV) can lead to both benign conditions like genital warts and serious issues like various cancers, including oropharyngeal squamous cell carcinomas (OPSCCs).
  • The 9-valent HPV vaccine (Gardasil 9) protects against high-risk HPV strains linked to OPSCC, aiming to lower the rates of all HPV-associated cancers through widespread vaccination.
  • The article focuses on educating oral healthcare providers about the HPV vaccination schedule and its effectiveness in preventing OPSCCs, emphasizing the differences between HPV-related and non-HPV-related OPSCCs in terms of treatment response and clinical presentation.
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We aimed to describe obstetrics and gynecology (OBGYN) trainees' anticipation of how the U.S. Supreme Court decision may affect their training.

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Background: The COVID-19 pandemic created new challenges and barriers for the work of child protection professionals (CPPs) and intensified existing hardships for families and children, increasing the risk of child maltreatment. As new restrictions and precautions were implemented by governments worldwide to stop the virus from spreading, CPPs had to adapt to a new reality of working remotely. However, limited research has investigated how remote work impacted CPPs and child protection work and how CPPs handled this alternative work style.

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Aquatic fishes are threatened by the strong pathogenic bacterium Nocardia seriolae, which challenges the current prevention and treatment approaches. This study introduces luminogens with aggregation-induced emission (AIE) as an innovative and non-antibiotic therapy for N. seriolae.

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Background: The COVID-19 pandemic increased the likelihood of child maltreatment and made already difficult circumstances for children and their families much worse. This increased the significance of the child protection system's role in responding to child maltreatment and ensuring children's rights, including their right to a safe life without violence. Unfortunately, accumulating evidence has indicated that the rates of child maltreatment increased during the pandemic.

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Background: COVID-19 significantly worsened already challenging circumstances for children and their families and globally increased the likelihood of child maltreatment. This risk heightened the urgency of child protection professionals in preventing child maltreatment and defending children's rights. The vast and growing body of research on protecting children from child maltreatment during COVID-19 has emphasized practitioners' tremendous difficulty in this arena.

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