Publications by authors named "Chang Ming Ling"
Background: The phenotype of cryoglobulinemia in hepatitis B virus (HBV) carriers remains elusive.
Methods: A 7-year prospective cohort of 648 hepatitis B e antigen (HBeAg)-negative Taiwanese HBV carriers [males: 344 (53%)] was conducted.
Results: Among 648, 189 (29.
Article Synopsis
- - MASLD is a widespread chronic liver disease, affecting over 30% of people globally, and is primarily linked to metabolic issues like insulin resistance and type 2 diabetes.
- - There is a significant two-way relationship between MASLD and diabetes, influencing each other's progression and treatment outcomes.
- - Collaborative efforts from Taiwanese health organizations have led to new guidelines aimed at improving patient care for those with both diabetes and MASLD, focusing on surveillance and management strategies.
Article Synopsis
- A nationwide cohort study in Taiwan investigated the relationship between Hepatitis C Virus (HCV) infection and the development of colorectal cancer (CRC), colon cancer (CC), and rectal cancer (RC).
- The findings showed that HCV-uninfected patients had the lowest incidence of CRC, while both HCV-treated and untreated groups demonstrated similar, higher incidences.
- The study identified various risk factors, including age over 49, male sex, and diabetes, as significant contributors to cancer development among HCV-infected individuals, highlighting the complexity of cancer risk factors related to HCV.
Distinct characteristics of various autoimmune liver diseases: A 22-year hospital-based study in Taiwan.
J Gastroenterol Hepatol
December 2024
Article Synopsis
- The study investigates and compares characteristics of autoimmune liver diseases (AILDs), specifically primary biliary cholangitis (PBC), autoimmune hepatitis (AIH), and PBC-AIH overlap syndrome (OS) in an Asian population.
- It shows that PBC patients are older, have higher female-to-male ratios, and exhibit greater rates of complications such as cirrhosis and dyslipidemia compared to AIH patients, with notable differences in liver function markers and mortality rates.
- The research emphasizes the need for special attention to older PBC patients, particularly females with obesity, due to their higher risks of liver complications and hepatocellular carcinoma (HCC).
: Patients with cirrhosis are susceptible to sepsis and septic shock. Cirrhotic patients also have increased capillary permeability and are prone to developing volume overload. Patients with septic shock may have an enhanced pulmonary vascular permeability index (PVPI) and extravascular lung water index (EVLWI), both of which are associated with an unfavorable prognosis.
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- The study aimed to estimate the prevalence and incidence rates of inflammatory bowel disease (IBD) in Taiwan from 2016 to 2020 due to a lack of population-based research.
- Between 2016 and 2020, there were 2,595 registered cases of IBD (Crohn's Disease and Ulcerative Colitis) with a noted increase in incidence rates for both conditions, indicating a rising trend in IBD cases.
- The findings suggest that Taiwan is experiencing an "acceleration in incidence stage" for IBD, emphasizing the need to understand geographic variations in disease occurrence as the global burden of IBD continues to grow.
Article Synopsis
- Colorectal cancer (CRC) poses a significant global health risk, making the use of adjuvant chemotherapy post-surgery crucial for reducing recurrence and improving survival, especially in intermediate-stage patients.
- This study investigates the genetic mechanisms influencing the effectiveness of 5-fluorouracil (5-FU)-based chemotherapy using a genome-wide association study (GWAS) on 226 intermediate-stage CRC patients who received surgery followed by treatment.
- Key findings highlight the genetic variant -rs62139523, particularly the "A/G" genotype, as a promising biomarker that predicts better survival outcomes in these patients, though its efficacy varies based on certain demographic and clinical factors.
The study aims to evaluate the efficacy of peripheral blood inflammatory markers as clinical predictors for gastric intestinal metaplasia (IM), a known precursor to gastric cancer. This research investigates the potential of these markers to serve as reliable indicators for detecting gastric IM. A retrospective cohort study was conducted on 59,143 individuals who underwent checkups at the Taoyuan Chang Gung Memorial Hospital Health Clinic Center from 2010 to 2014.
View Article and Find Full Text PDFAim: The response rate to pioglitazone and the predictive factors for its effects on improving liver biochemistry in patients with steatotic liver disease (SLD) remain elusive, so we aimed to investigate these issues.
Methods: A 3-year prospective cohort study of 126 Taiwanese patients with SLD treated with pioglitazone (15-30 mg/day) was conducted. Phospholipase domain-containing protein 3 I148M rs738409, methylenetetrahydrofolate reductase rs1801133, aldehyde dehydrogenase 2 (ALDH2) rs671 and lipoprotein lipase rs10099160 single nucleotide polymorphisms were assessed in the patients.
Background: The characteristics of autoimmune hepatitis (AIH) in Asia mostly remain elusive.
Methods: A cohort study of liver biopsy-proven AIH patients was conducted in a tertiary care cancer of Taiwan.
Results: From 1999 to 2022, of 13,766 patients who underwent liver biopsy, 150 patients with AIH were enrolled.
Background: How antimitochondrial antibody (AMA)-positive patients evolve to have primary biliary cholangitis (PBC) in viral hepatitis-endemic areas is unknown.
Objectives: We aimed to investigate this evolution in Taiwan.
Design/methods: A 16-year medical center-based cohort study of 2,095,628 subjects was conducted in Taiwan, an Asian country endemic to viral hepatitis.
Hepatocellular carcinoma (HCC) is an aggressive tumor that usually occurs in patients with chronic liver disease and cirrhosis. Surgical resection is an optimal treatment for HCC, but the 5-year recurrence rates are significantly high. The majority of recurrent HCCs occur through intrahepatic metastasis with local tumor progression, and less than 20% of recurrences are extrahepatic metastases.
View Article and Find Full Text PDFBackground / Aims: Effects of anti-hepatitis C virus (HCV) therapeutic regimens and mixed cryoglobulinemia on long-term renal function of HCV-infected patients with viral clearance have not been determined.
Methods/materials: A prospective 10-year cohort study of 1212 HCV-infected patients (interferon-based therapy, n = 615; direct-acting antiviral (DAA) therapy, n = 434) was conducted.
Results: At baseline, age, body mass index (BMI), hemoglobin (Hb) and uric acid (UA) levels, and fibrosis-4 score were associated with estimated glomerular filtration rates (eGFRs) in HCV-infected patients.
The impacts of patatin-like phospholipase domain-containing protein 3 (PNPLA3) I148M-rs738409, methylenetetrahydrofolate reductase (MTHFR) Ala222Val-rs1801133, and aldehyde dehydrogenase 2 (ALDH2) Glu504Lys-rs671 on the outcomes of Taiwanese patients with steatotic liver disease (SLD) have remained elusive. An 8-year prospective cohort study of patients with (n = 546) and without (n = 580) SLD (controls) was undertaken in a Taiwanese tertiary care center. The 546 SLD patients comprised 306 (56.
View Article and Find Full Text PDFObjectives: To explore the molecular characteristics of rpoB, encoding β-subunit of DNA-directed RNA polymerase, and unravel the link to rifabutin-resistance in patients with refractory Helicobacter pylori infection.
Methods: From January 2018-March 2021, a total of 1590 patients were screened for eligibility to participate in the study. Patients with refractory H.
Article Synopsis
- - Metabolic dysfunction-associated fatty liver disease (MAFLD) is a rising global health concern that is diagnosed through imaging, histology, or serum markers, alongside metabolic conditions like obesity and type 2 diabetes.
- - MAFLD not only affects the liver but is also linked to cardiovascular diseases (CVD), which significantly increase the health risks and mortality for affected individuals.
- - A recent position statement from Taiwan synthesizes research on MAFLD's prevalence, risk factors, and treatment options, emphasizing the need for collaboration between liver and heart specialists to better manage this interrelated health issue.
Hepatitis C virus (HCV) infection causes many cancers, including intrahepatic cholangiocarcinoma. Whether it increases the risk of extrahepatic cholangiocarcinoma (ECC) is unknown. A 10-year nationwide population-based cohort study of the Taiwan National Health Insurance Research Database (TNHIRD) was conducted.
View Article and Find Full Text PDFBackground: Acoustic radiation force impulse (ARFI) is used to measure liver fibrosis and predict outcomes. The performance of elastography in assessment of fibrosis is poorer in hepatitis B virus (HBV) than in other etiologies of chronic liver disease.
Aim: To evaluate the performance of ARFI in long-term outcome prediction among different etiologies of chronic liver disease.
Aim: Data on the geoepidemiology and outcomes of primary biliary cholangitis (PBC) in Asia are limited; thus, we aimed to collect and assess this information for Taiwan.
Methods: A nationwide population-based cohort study was undertaken using data from the Taiwan National Health Insurance Research Database. Primary biliary cholangitis was defined by the International Classification of Diseases, Ninth Revision, Clinical Modification code 571.
Background/aims: The implications of extracellular nicotinamide phosphoribosyltransferase (eNAMPT), a cancer metabokine, in colonic polyps remain uncertain.
Methods: A 2-year prospective cohort study of patients who underwent colonoscopy was conducted. Biochemical parameters and serum eNAMPT levels were analyzed at baseline and every 24 weeks postpolypectomy.
Worldwide, an estimated 296 million people are living with chronic hepatitis B virus (HBV) infection, with a significant risk of morbidity and mortality. Current therapy with pegylated interferon (Peg-IFN) and indefinite or finite therapy with nucleoside/nucleotide analogues (Nucs) are effective in HBV suppression, hepatitis resolution, and prevention of disease progression. However, few achieve hepatitis B surface antigen (HBsAg) loss (functional cure), and relapse often occurs after the end of therapy (EOT) because these agents have no direct effect on durable template: covalently closed circular DNA (cccDNA) and integrated HBV DNA.
View Article and Find Full Text PDFConcurrent hepatitis B virus (HBV) and hepatitis C virus (HCV) infection is not uncommon as the two viruses shared the similar transmission routes. HCV is usually the dominant virus to suppress HBV, and HBV reactivation may occur during or after the course of anti-HCV treatment. By contrast, HCV reactivation after anti-HBV therapy in the concurrent HBV- and HCV-infected patients was rarely noted.
View Article and Find Full Text PDFBackground And Aim: World Health Organization sets up an ambitious and attainable goal to eliminate hepatitis C (HCV) by 2030. The previous diagnosed HCV patients lost to follow-up were considered as an important target group for HCV elimination. We conducted a call back program to retrieve the lost to follow-up HCV patients and link them to care in our hospital.
View Article and Find Full Text PDFKimura disease (KD) is a rare, chronic proliferative condition presenting as a subcutaneous mass predominantly located in the head and neck region; it is characterized by eosinophilia and elevated serum IgE levels. IgG4-related disease (IgG4RD) is a fibroinflammatory condition characterized by swelling in single or multiple organs and the infiltration of IgG4 plasma cells. Herein, we presented two cases.
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