GSDMD-mediated mitochondrial dysfunction in marginal cells: A potential driver of inflammation and stria vascularis damage in CIHL.

Inflammation is among the known causes of cisplatin-induced hearing loss (CIHL), but its exact pathophysiological mechanisms remain unclear. Herein, we demonstrated that pyroptosis-a recently identified inflammatory type of regulated cell death dependent on gasdermin D (GSDMD)-was activated in the cochleae of cisplatin-treated mice, causing CIHL. Meanwhile, treatment with the GSDMD inhibitor necrosulfonamide alleviated CIHL in these mice.

Chronic Cutaneous and Mucosal Mucormycosis: as a Major Pathogenic Fungus.

Chronic cutaneous mucormycosis is a rare condition distinct from the acute form, characterized by a prolonged, indolent course and varied clinical presentations. This study presents a 5-year experience from a tertiary dermato-mycology clinic, identifying six cases, the majority of whom were immunocompetent, with trauma history reported in four patients. The median duration from symptom onset to diagnosis was 60 months.

RAB4B and Japanese encephalitis virus E protein interaction is essential for viral entry in early endosomes.

RAB4B (Ras-Related GTP-Binding Protein 4b) is essential for intracellular trafficking and endosomal recycling processes. Our previous study, we demonstrated that RAB4B promotes Japanese encephalitis virus (JEV) replication in PK15 cells. However, the exact mechanisms underlying the role of RAB4B in JEV internalization remain unclear.

[Hydrochemical Characteristics and Mechanism Analysis of Shallow Groundwater in Beijing Plain Area].

Groundwater is an important resource for alleviating global water scarcity. Therefore, understanding its hydrochemical characteristics and mechanisms is of great significance for groundwater management. A total of 210 groundwater samples from shallow monitoring wells in the plain area of Beijing were collected in this study.

Differential effects of high-fiber and low-fiber diets on anti-tumor immunity and colon tumor progression in a murine model.

The role of dietary fiber in colon cancer prevention remains controversial. We investigated its impact on anti-tumor immunity and the gut microbiota in APCmin/+ mice infected with Enterotoxigenic Bacteroides fragilis. Mice were fed high-fiber, low-fiber, or chow diets, and tumor burden, survival, cytokines, microbiota, and metabolites were analyzed.

The Japanese encephalitis virus NS1' protein facilitates virus infection in mosquitoes.

Background: The Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, is known for its capacity to cause severe neurological disease in Asia. Neurotropic flaviviruses within the Japanese encephalitis (JE) serogroup possess the distinctive feature of expressing a unique nonstructural protein, NS1'. The NS1' protein consists of the full NS1 protein with an additional 52 amino acid extension at the C-terminus and has been demonstrated to exhibit virulence in mammalian hosts upon infection.

Application of perovskite type oxide La Ce coo in lignin depolymerization and mono-phenol preparation.

This study successfully prepared La Ce CoO ( = 0.2, 0.4, 0.

Synergistic Binding Sites in a Robust and Scalable Metal-Organic Framework for Record CH Capture.

Effectual CH reclamation from CH/N blends by existing physisorbents in industrialization confronts the adversity of frustrated separation performance, weak structural strength, and restricted scale-up preparation. To solve aforesaid bottlenecks, herein, a strategy is presented to fabricate synergistic strong recognition binding sites in a robust and scalable optimum Cu(pma) with ultramicroporous feature regarding superb CH separation versus N. By virtue of the synergistic contribution of multiple affinities accompanied by enormous potential field overlap of pore restriction, it imparts strong recognition binding toward CH molecules.

Research Progress on Glioma Microenvironment and Invasiveness Utilizing Advanced Multi-Parametric Quantitative MRI.

Magnetic resonance imaging (MRI) currently serves as the primary diagnostic method for glioma detection and monitoring. The integration of neurosurgery, radiation therapy, pathology, and radiology in a multi-disciplinary approach has significantly advanced its diagnosis and treatment. However, the prognosis remains unfavorable due to treatment resistance, inconsistent response rates, and high recurrence rates after surgery.

A novel peptide CP29L, selected from the phage displayed cyclic random heptapeptide library, demonstrates its potent inhibitory effects to liver cancer HCCLM3 cells by targeting FOXM1.

FOXM1 is the "Achilles' heel" of cancers and hence the potential therapeutic target for anticancer drug discovery. In this work, we selected high affinity peptides against the protein of human DNA binding domain of FOXM1 (FOXM1-DBD) from the disulfide-constrained, phage displayed random cyclic heptapeptide library Ph.D.

Integrated Oxygen-Constraining Strategy for Ni-Rich Layered Oxide Cathodes.

Surface engineering is sought to stabilize nickel-rich layered oxide cathodes in high-energy-density lithium-ion batteries, which suffer from severe surface oxygen loss and rapid structure degradation, especially during deep delithiation at high voltages or high temperatures. Here, we propose a well-designed oxygen-constraining strategy to address the crisis of oxygen evolution. By integrating a La, Fe gradient diffusion layer and a LaFeO coating into the Ni-rich layered particles, along with incorporating an antioxidant binder into the electrodes, three progressive lines of defense are constructed: immobilizing the lattice oxygen at the subsurface, blocking the released oxygen at the interface, and capturing the residual singlet oxygen on the external surface.

Cost-Effective, Hydrogen-Rich, and Ultramicroporous Metal-Organic Framework for Efficient Separation of SF from N.

It is essential for the industry to create an adsorbent that combines a high capacity with selectivity to achieve the effective separation of SF from gas mixtures. In this study, we prepared a cost-effective nickel-based metal-organic framework (MOF), Ni(BTC)(BPY), which features hydrogen-rich ultramicroporous channels specifically designed for separating SF/N gas mixtures. The findings from the adsorption experiments demonstrated that Ni(BTC)(BPY) achieved a remarkable SF adsorption capacity of 5.

In-situ Ti-doped modification of layer-structured Ni-rich LiNiCoMnO cathode materials for high-energy lithium-ion batteries.

The further commercialization of layer-structured Ni-rich LiNiCoMnO (NCM83) cathode for high-energy lithium-ion batteries (LIBs) has been challenged by severe capacity decay and thermal instability owing to the microcracks and harmful phase transitions. Herein, Ti-doped NCM83 cathode materials are rationally designed via a simple and low-cost in-situ modification method to improve the crystal structure and electrode-electrolyte interface stability by inhibiting irreversible polarizations and harmful phase transitions of the NCM83 cathode materials due to Ti-doped forms stronger metal-O bonds and a stable bulk structural. In addition, the optimal doping amount of the composite cathode material is also determined through the results of physical characterization and electrochemical performance testing.

Insight into the Role of Rb Doping for Highly Efficient Kesterite CuZnSn(S,Se) Solar Cells.

Various copper-related defects in the absorption layer have been a key factor impeding the enhancement of the efficiency of CuZnSn(S,Se) (CZTSSe) solar cells. Alkali metal doping is considered to be a good strategy to ameliorate this problem. In this article, Rb-doped CZTSSe (RCZTSSe) thin films were synthesized using the sol-gel technique.

Anti-CTLA-4 m2a Antibody Exacerbates Cardiac Injury in Experimental Autoimmune Myocarditis Mice By Promoting Ccl5-Neutrophil Infiltration.

The risk for suffering immune checkpoint inhibitors (ICIs)-associated myocarditis increases in patients with pre-existing conditions and the mechanisms remain to be clarified. Spatial transcriptomics, single-cell RNA sequencing, and flow cytometry are used to decipher how anti-cytotoxic T lymphocyte antigen-4 m2a antibody (anti-CTLA-4 m2a antibody) aggravated cardiac injury in experimental autoimmune myocarditis (EAM) mice. It is found that anti-CTLA-4 m2a antibody increases cardiac fibroblast-derived C-X-C motif chemokine ligand 1 (Cxcl1), which promots neutrophil infiltration to the myocarditic zones (MZs) of EAM mice via enhanced Cxcl1-Cxcr2 chemotaxis.

Sialic acids as attachment factors in mosquitoes mediating Japanese encephalitis virus infection.

The role of mosquitoes in the transmission of Japanese encephalitis virus (JEV) is crucial, yet the mechanisms of JEV infection in these vectors remain unclear. Previous research has indicated that various host factors participate in JEV infection. Herein, we present evidence that mosquito sialic acids enhance JEV infection both and .

[Water-soluble Inorganic Ion Content of PM and Its Change Characteristics in Urban Area of Beijing in 2022].

To explore the content and variation characteristics of water-soluble ions of atmospheric fine particles (PM) in a Beijing urban area and put forward the pollution prevention and control scheme, the water-soluble ions, gaseous precursors (SO, NO), and meteorological factors (temperature, RH) of PM in 2022 were analyzed and determined. The results showed that the water-soluble ions with the highest proportion in PM in the Beijing City urban area were NO, NH, and SO, accounting for 52.7% of PM.

FDA-Approved Tedizolid Phosphate Prevents Cisplatin-Induced Hearing Loss Without Decreasing Its Anti-tumor Effect.

Purpose: Cisplatin is a low-cost clinical anti-tumor drug widely used to treat solid tumors. However, its use could damage cochlear hair cells, leading to irreversible hearing loss. Currently, there appears one drug approved in clinic only used for reducing ototoxicity associated with cisplatin in pediatric patients, which needs to further explore other candidate drugs.

Longitudinal Lower Airway Microbial Signatures of Acute Cellular Rejection in Lung Transplantation.

Acute cellular rejection (ACR) after lung transplant is a leading risk factor for chronic lung allograft dysfunction. Prior studies have demonstrated dynamic microbial changes occurring within the allograft and gut that influence local adaptive and innate immune responses. However, the lung microbiome's overall impact on ACR risk remains poorly understood.

Altered dynamic effective connectivity of the default mode network in type 2 diabetes.

Introduction: Altered functional connectivity of resting-state functional magnetic resonance imaging (rs-fMRI) within default mode network (DMN) regions has been verified to be closely associated with cognitive decline in patients with Type 2 diabetes mellitus (T2DM), but most studies neglected the fluctuations of brain activities-the dynamic effective connectivity (DEC) within DMN of T2DM is still unknown.

Methods: For the current investigation, 40 healthy controls (HC) and 36 T2DM patients have been recruited as participants. To examine the variation of DEC between T2DM and HC, we utilized the methodologies of independent components analysis (ICA) and multivariate granger causality analysis (mGCA).

State- and trait-related dysfunctions in bipolar disorder across different mood states: a graph theory study.

Background: The interplay between state- and trait-related disruptions in structural networks remains unclear in bipolar disorder (BD), but graph theory can offer insights into global and local network changes. We sought to use diffusion-tensor imaging (DTI) and graph theory approaches to analyze structural topological properties across distinct mood states and identify high-risk individuals by examining state- and trait-related impairments in BD.

Methods: We studied changes in white matter network among patients with BD and healthy controls, exploring relationships with clinical variables.