Publications by authors named "Chang K"

Surface subsidence hazards in mining areas are common geological disasters involving issues such as vegetation degradation and ground collapse during the mining process, which also raise safety concerns. To address the accuracy issues of traditional prediction models and study methods for predicting subsidence in open-pit mining areas, this study first employed 91 scenes of Sentinel-1A ascending and descending orbits images to monitor long-term deformations of a phosphate mine in Anning City, Yunnan Province, southwestern China. It obtained annual average subsidence rates and cumulative surface deformation values for the study area.

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Background: Identification of pulmonary embolism (PE) across a cohort currently requires burdensome manual review. Previous approaches to automate capture of PE diagnosis have either been too complex for widespread use or have lacked external validation. We sought to develop and validate the Regular Expression Aided Determination of PE (READ-PE) algorithm, which uses a portable text-matching approach to identify PE in reports from computed tomography with angiography (CTA).

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Adolescents in low- and middle-income countries (LMICs) are a vulnerable population given increased nutritional needs as puberty approaches. School-based nutrition programs exist in some settings, but the comprehensive provision of nutrition services requires knowledge of the mechanisms to reach out-of-school adolescents. A comprehensive scoping review was performed using formal and informal search strategies to landscape all potential delivery platforms with nutrition services to reach adolescents.

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Background: This study was designed to evaluate the diagnostic efficacy of the minimum fascia-tumour distance (MFTD) in distinguishing deep-lobe benign parotid tumours from superficial-lobe tumours through both an original study and a meta-analysis.

Methods: In this study, we performed a retrospective analysis of data from 91 patients who had been diagnosed with benign parotid tumours. The MFTD values were sourced from preoperative ultrasound examinations.

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Background: Pleomorphic xanthoastrocytoma (PXA) is a rare brain tumor that accounts for <1% of all gliomas. An in-depth understanding of PXA's molecular makeup remains a work in progress due to its limited numbers globally. Separately, spontaneous intracranial hemorrhage (pICH) is an uncommon but potentially devastating emergency in young children, often caused by vascular malformations or underlying hematological conditions.

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Solving the Hamiltonian of a system yields the energy dispersion and eigenstates. The geometric phase of the eigenstates generates many novel effects and potential applications. However, the geometric properties of the energy dispersion go unheeded.

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Article Synopsis
  • The study examines symptom phenotypes of COVID-19 patients to identify subtypes with different outcomes and prognoses for better management of the disease.
  • It analyzes 14,139 electronic medical records from Hubei Province, employing deep learning and clustering algorithms to classify patients into three distinct subtypes based on their symptoms.
  • The identified subtypes reveal significant differences in prognosis, with Subtype 0 showing the highest mortality rate (4.72%) and specific symptom patterns that may help forecast patient outcomes.
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Background: Many municipalities in rural areas of Korea are facing population decline due to the aging population phenomenon. This study examined the relationship between residing in municipalities facing population decline and satisfaction with nearby healthcare infrastructure in older aged adults.

Methods: The 2021 Korea Community Health Survey (KCHS) data were used.

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Artificial intelligence (AI) shows potential to improve health care by leveraging data to build models that can inform clinical workflows. However, access to large quantities of diverse data is needed to develop robust generalizable models. Data sharing across institutions is not always feasible due to legal, security, and privacy concerns.

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Significance: Many techniques exist for screening retinal phenotypes in mouse models in vision research, but significant challenges remain for efficiently probing higher visual centers of the brain. Photoacoustic computed tomography (PACT), with optical sensitivity to hemodynamic response (HR) in brain and ultrasound resolution, provides unique advantages in comprehensively assessing higher visual function in the mouse brain.

Aim: We aim to examine the reliability of PACT in the functional phenotyping of mouse models for vision research.

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Osteoarthritis (OA) is a chronic degenerative disease leading to articular cartilage destruction. Menopausal and postmenopausal women are susceptible to both OA and osteoporosis. S-equol, a soy isoflavone-derived molecule, is known to reduce osteoporosis in estrogen-deficient mice, but its role in OA remains unknown.

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Herein, we explore whether coil embolization (CE) is effective in treating veno-occlusive dysfunction (VOD). We present five cases with seven CE episodes and a narrative literature review. From 2013 to 2018, refractory impotence prompted five men to seek penile vascular stripping (PVS), although seven CE episodes were included.

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Article Synopsis
  • Patellofemoral pain syndrome (PFPS) is a common cause of knee pain, and lumbopelvic manipulation (LPM) may help reduce this pain.
  • A meta-analysis of ten randomized controlled trials involving 346 participants found significant pain reduction in those receiving LPM compared to a control group.
  • LPM, especially when combined with other therapies, is considered a safe and effective treatment option, and clinicians are encouraged to incorporate it into PFPS management plans.
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The goal of stroke rehabilitation is to establish a robust protocol for patients to live independently in community. Firstly, we examined the impact of 3 hybridized transcranial direct current stimulation (tDCS)-mirror therapy interventions on activities of daily life (ADL) in stroke patients. Secondly, we explored the underlying therapeutic mechanisms with theory-driven electroencephalography (EEG) indexes in the alpha band.

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Vascular complications arising from dermal filler treatments pose significant risks, including ischemia, tissue necrosis, and severe outcomes like blindness and pulmonary embolism. This study investigates the mechanisms of vascular complications, categorizing them into extravascular compression and intravascular emboli. Extravascular compression occurs when injected fillers compress adjacent blood vessels, leading to ischemia and potential necrosis, while intravascular emboli result from fillers entering blood vessels, causing blockages.

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Background: Several studies suggest an "obesity paradox," associating obesity with better cardiovascular outcomes in patients with type 2 diabetes mellitus (DM) or aortic stenosis (AS) compared to normal or underweight individuals. This study explores the impact of body mass index (BMI) on diabetic patients with AS.

Methods: Between 2014 and 2019, patients with DM who underwent echocardiography were analyzed.

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Huntington's disease (HD) is characterized by progressive involuntary chorea movements and cognitive decline. Recent research indicates that metabolic disturbance may play a role in its pathogenesis. Bile acids, produced during cholesterol metabolism in the liver, have been linked to neurodegenerative conditions.

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Marine natural products offer immense potential for drug development, but the limited supply of marine organisms poses a significant challenge. Establishing aquaculture presents a sustainable solution for this challenge by facilitating the mass production of active ingredients while reducing our reliance on wild populations and harm to local environments. To fully utilize aquaculture as a source of biologically active products, a cell-free system was established to target molecular components with protein-modulating activity, including topoisomerase II, HDAC, and tubulin polymerization, using extracts from aquaculture corals.

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A user's devices such as their phone and computer are constantly bombarded by IoT devices and associated applications seeking connection to the user's devices. These IoT devices may or may not seek explicit user consent, thus leaving the users completely unaware the IoT device is collecting, using, and/or sharing their personal data or, only marginal informed, if the user consented to the connecting IoT device but did not read the associated privacy policies. Privacy policies are intended to inform users of what personally identifiable information (PII) data will be collected about them and the policies about how those PII data will be used and shared.

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Article Synopsis
  • The study investigates how limbic networks are affected in individuals with Amyotrophic Lateral Sclerosis (ALS), particularly focusing on emotional and cognitive deficits.
  • It involved 204 ALS patients and 111 healthy controls, using advanced imaging techniques to analyze specific brain regions associated with memory and emotion.
  • Results showed significant atrophy in key brain areas of ALS patients, regardless of genetic factors, emphasizing the need for thorough neuropsychological assessments in ALS diagnosis and treatment.
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Unlike traditional photoluminescence (PL), mechanoluminescence (ML) achieved under mechanical excitation demonstrates unique characteristics such as high penetrability, spatial resolution, and signal-to-background ratio (SBR) for bioimaging applications. However, bioimaging with organic mechanoluminescent materials remains challenging because of the shallow penetration depth of ML with short emission wavelengths and the absence of a suitable mechanical force to generate ML in vivo. To resolve these issues, the present paper reports the achievement of ultrasound (US)-excited fluorescence and phosphorescence from purely organic luminogens for the first time with emission wavelengths extending to the red/NIR region, with the penetrability of the US-excited emission being considerably higher than that of PL.

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Background: Xiaoke Bitong capsule (XBC) is a crude herbal compound believed to tonify qi, improve blood circulation, and alleviate blood stasis. It has been used as an herbal formula for the prevention and treatment of diabetic peripheral neuropathy (DPN) under the guidance of traditional Chinese medicine (TCM). However, the pharmacological mechanisms by which XBC ameliorates DPN remain poorly understood.

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Objective: The recent surge in large language models (LLMs) across various fields has yet to be fully realized in traditional Chinese medicine (TCM). This study aims to bridge this gap by developing a large language model tailored to TCM knowledge, enhancing its performance and accuracy in clinical reasoning tasks such as diagnosis, treatment, and prescription recommendations.

Materials And Methods: This study harnessed a wide array of TCM data resources, including TCM ancient books, textbooks, and clinical data, to create 3 key datasets: the TCM Pre-trained Dataset, the Traditional Chinese Patent Medicine (TCPM) Question Answering Dataset, and the Spleen and Stomach Herbal Prescription Recommendation Dataset.

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