Effectiveness of Osteoporosis Drug in Postmenopausal Women with Spinal Compression Fracture: Combined Consecutive Therapy of Teriparatide and Raloxifene versus Bisphosphonate Single.

Objective: Bisphosphonate, a typical bone resorption inhibitor, is an important first-line drug for treating osteoporosis. Recent studies show a novel paradigm in stimulating bone formation. Teriparatide, which is composed of recombinant human parathyroid hormone, stimulates osteoblasts and induces bone regeneration.

Rapid Visual Deterioration Caused by Posterior Fossa Arachnoid Cyst.

Posterior fossa is a site next to the middle fossa where arachnoid cyst frequently occurs. Generally, most arachnoid cysts are asymptomatic and are found incidentally in most cases. Although arachnoid cysts are benign and asymptomatic lesions, patients with posterior fossa arachnoid cysts often complain of headaches, gait disturbance, and ataxia due to the local mass effects on the cerebellum.

Rewiring the dynamic interactome.

Transcriptomics continues to provide ever-more evidence that in morphologically complex eukaryotes, each protein-coding genetic locus can give rise to multiple transcripts that differ in length, exon content and/or other sequence features. In humans, more than 60% of loci give rise to multiple transcripts in this way. Motifs that mediate protein-protein interactions can be present or absent in these transcripts.

Towards the mammalian interactome: Inference of a core mammalian interaction set in mouse.

Protein-protein interactions (PPIs) underpin key biological processes in cells. Describing and interpreting this network of interactions is a key focus of computational systems biology. While mouse is commonly used as a model system for mammalian biology, the description of mouse PPIs available in public interaction databases is remarkably poor.

Protein-protein interaction as a predictor of subcellular location.

Background: Many biological processes are mediated by dynamic interactions between and among proteins. In order to interact, two proteins must co-occur spatially and temporally. As protein-protein interactions (PPIs) and subcellular location (SCL) are discovered via separate empirical approaches, PPI and SCL annotations are independent and might complement each other in helping us to understand the role of individual proteins in cellular networks.