Publications by authors named "Chang Il Kim"
Article Synopsis
- The study focuses on understanding how the HPAI H5N8 virus adapts and spreads between species by identifying specific genetic markers associated with its virulence in mammals.
- Researchers used deep sequencing in mice to track these adaptive markers through multiple virus passages, followed by experiments on eight recombinant viruses to assess their growth and RNA expression.
- By employing a sophisticated regression model, the team quantified how these markers interact, revealing that their combinations can have various effects and allowing for the creation of a risk score, which can aid in developing strategies to tackle future influenza outbreaks.
Baloxavir marboxil (BXM) treatment-emergent polymerase acid (PA) I38X amino acid substitution (AAS) in the resistant variants of influenza viruses raise concerns regarding their emergence and spread. This study investigated the impact of 1 or 5 mg/kg BXM and 25 mg/kg oseltamivir phosphate (OS) (single or combination therapy) on the occurrence of resistance-related substitutions during the sequential lung-to-lung passages of AH1N1)pdm09 virus in mice. Deep sequencing analysis revealed that 67% (n = 4/6) of the population treated with BXM single therapy (1 or 5 mg/kg) possessed the treatment-emergent PA-I38X AAS variants (I38T, I38S, and I38V).
View Article and Find Full Text PDFModeling the electrophoretic mobility of peptides is examined in this study using a "coarse grained" bead model, or B model for short 8 and also a simpler "effective sphere" (ES) model. A comparison between the B and ES models is carried out for peptide models covering a broad range of ionic strength, peptide charge, and peptide length. At ionic strengths lower than approximately 0.
View Article and Find Full Text PDF