Publications by authors named "Chang Hong Liang"

Rationale And Objectives: Metaplastic breast carcinoma (MBC) is an infrequent malignancy with an unfavorable prognosis, and there is a paucity of research on the multimodal imaging features of MBC. This study aimed to provide a comprehensive analysis of the multimodal imaging features, clinicopathological characteristics, and prognosis of MBC.

Materials And Methods: A total of 36 patients with histologically confirmed MBC from 2012 to 2021 were included in the study.

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Purpose: To evaluate the potential application of radiomics in predicting Tumor-Node-Metastasis (TNM) stage in patients with resectable esophageal squamous cell carcinoma (ESCC).

Methods: This retrospective study included 122 consecutive patients (mean age, 57 years; 27 women). Corresponding tumor of interest was identified on axial arterial-phase CT images with manual annotation.

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Article Synopsis
  • The study aimed to develop and validate the immune ecosystem diversity index (iEDI) as a non-invasive imaging biomarker to assess intratumoural immune status in non-small cell lung cancer (NSCLC).
  • Researchers analyzed two independent cohorts of NSCLC patients, measuring T cell densities and using preoperative CT scans to correlate with patient survival outcomes.
  • Results showed that higher iEDI scores were associated with longer overall survival, indicating its potential as a prognostic tool for NSCLC patients undergoing surgery.
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Purpose: We aimed to explore the influence of tube voltage, current and iterative reconstruction (IR) in computed tomography perfusion imaging (CTPI) and to compare CTPI parameters with microvessel density (MVD).

Methods: Hepatic CTPI with three CTPI protocols (protocol A, tube voltage/current 80 kV/40 mAs; protocol B, tube voltage/current 80 kV/80 mAs; protocol C: tube voltage/current 100 kV/80 mAs) were performed in 25 rabbit liver VX2 tumor models, and filtered back projection (FBP) and IR were used for reconstruction of raw data. Hepatic arterial perfusion (HAP), hepatic portal perfusion (HPP), total perfusion (TP), hepatic arterial perfusion index (HPI), blood flow (BF) and blood volume (BV) of VX2 tumor and normal hepatic parenchyma were measured.

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Background: The recent outbreak of pneumonia cases in Wuhan, PR China, was caused by a novel beta coronavirus, the 2019 novel coronavirus (COVID-19).

Purpose: To summarize chest computed tomography (CT) manifestations of the early stage of COVID-19 infection and provide a piece of reliable imaging evidence for initial screening and diagnosis.

Material And Methods: From 10 January 2020 to 10 February 2020, we continuously observed chest CT imaging of 14 patients with clinically suspected new coronavirus infection in the two weeks after onset of symptoms.

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Objective: To review the imaging features of coronary artery-to-pulmonary artery fistula (CPAF) on CT coronary angiography (CTCA) and evaluate its diagnostic performance compared with coronary catheter angiography (CCA) and transthoracic echocardiography (TTE).

Materials And Methods: We retrospectively reviewed with a diagnosis of CPAF from among 19855 consecutive CCTA performed with 256-slice MDCT scanner for suspected coronary artery disease. CT images were evaluated for - origin, number, size and course (tubular/worm-like dilation/significant aneurysm formation/wall attachment sign) of fistula vessels, drainage site, drainage site imaging features (pierced sign, isodensity sign, smoke sign, jet sign), and main pulmonary artery (MPA) enlargement.

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Article Synopsis
  • Hepatocellular carcinoma (HCC) accounts for 85-90% of primary liver cancer cases in China, largely due to widespread chronic hepatitis B infection, making it a major health issue.* -
  • The National Health and Family Planning Commission of China released guidelines crafted by over 50 HCC experts, addressing surveillance, diagnosis, staging, and treatment strategies for HCC.* -
  • The guidelines include a Chinese staging system and recommendations aimed at optimizing patient outcomes for individuals with HCC in China.*
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Purpose: Petrous apex meningocele (PAM) is an uncommon cystic lesion involving the petrous apex. The underlying cause of PAM may be related to chronic elevated intracranial pressure. The aim of the study was to explore the relationship between PAM and meningioma and between PAM and other intracranial hypertension findings.

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Purpose: To investigate intravoxel incoherent motion (IVIM) MRI for evaluating the sensitivity of radiotherapy on nasopharyngeal carcinoma (NPC).

Results: The reproducibility between intra-observer and inter-observer was relatively good. (0.

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The identification of indicators for severe HFMD is critical for early prevention and control of the disease. With this goal in mind, 185 severe and 345 mild HFMD cases were assessed. Patient demographics, clinical features, MRI findings, and laboratory test results were collected.

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Objectives: The purpose of this study was to evaluate the differential diagnostic value of F-fluorodeoxy glucose positron emission tomography/computed tomography (F-FDG PET/CT) for benign and malignant testicular lesions.

Methods: The PET/CT scans of 53 patients with testicular lesions confirmed by biopsy or surgical pathology were retrospectively analyzed. There were 32 cases of malignant tumors and 21 cases of benign lesions.

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Purpose: The aims of this study were to describe the neuroimaging findings in hand, foot, and mouth disease and determine those who may provide prognosis.

Material And Methods: Magnetic resonance imaging scans in 412 severe hand, foot, and mouth disease between 2009 and 2014 were retrospectively evaluated. The patients who had the neurological signs were followed for 6 months to 1 year.

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The National Institute of Health defined cardiomyopathy as diseases of the heart muscle. These myocardial diseases have different etiology, structure and treatment. This review highlights the key imaging features of different myocardial diseases.

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The aim of this study was to discuss F-FDG PET/CT imaging characteristics and diagnostic values of angioimmunoblastic T-cell lymphoma (AITL). The PET/CT features of 24 cases of pathologically confirmed AITL were analyzed. The individual and total diagnostic values of 13 sites using computed tomography (CT) and positron emission tomography (PET)/CT were calculated.

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In this paper, full-wave electromagnetic scattering theory is employed to investigate illusion and invisibility of inhomogeneous anisotropic cylinders and spheres. With the use of a shell designed according to Mie series theory for multiple piecewise anisotropic layers, radar cross section (RCS) of the coated inhomogeneous anisotropic object can be dramatically reduced or disguised as another object in the long-wavelength limit. With the suitable adjustment of the anisotropy parameters of the shell, optimal illusion and invisibility characteristics of the coated inhomogeneous anisotropic object can be achieved.

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Purpose: To develop and validate a radiomics nomogram for preoperative prediction of lymph node (LN) metastasis in patients with colorectal cancer (CRC).

Patients And Methods: The prediction model was developed in a primary cohort that consisted of 326 patients with clinicopathologically confirmed CRC, and data was gathered from January 2007 to April 2010. Radiomic features were extracted from portal venous-phase computed tomography (CT) of CRC.

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  • The study aimed to assess how effective mammography, CT, and DCE-MRI are at detecting axillary lymph node metastasis in breast cancer patients.
  • A total of 109 women underwent these imaging tests, and their results were compared against histopathological assessments, which are considered the gold standard.
  • DCE-MRI outperformed both CT and mammography in accuracy and sensitivity for diagnosing lymph node metastasis, while mammography showed significantly lower effectiveness, suggesting caution when using it alone for this purpose.
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Background: The hypermetabolic environment of the myocardium, brown adipose tissue (BAT), and muscle will have an effect on the diagnostic accuracy of 18F-fluorodeoxyglucose (18F-FDG) positron-emission tomography (PET)/computed tomography (CT). A low carbohydrate, high fat, and protein-permitted diet before PET/CT scanning can reduce the degree of 18F-FDG uptake by the myocardium, brown adipose tissue, and skeletal muscle.

Purpose: To determine the effect of a low carbohydrate, high fat and protein-permitted diet on 18F-FDG uptake by myocardium, BAT, and muscle during PET/CT.

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Objectives: To investigate the potential of intravoxel incoherent motion (IVIM) to assess the renal pathophysiological process in contrast-induced acute kidney injury (CIAKI).

Methods: Twenty-seven rats were induced with CIAKI model, six rats were imaged longitudinally at 24 h prior to and 30 min, 12, 24, 48, 72 and 96 h after administration; three rats were randomly chosen from the rest for serum creatinine and histological studies. D, f, D* and ADC were calculated from IVIM, and renal blood flow (RBF) was obtained from arterial spin labelling (ASL).

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Objective: To discuss the value of (18)F-fluorodeoxyglucose-positron emission tomography ((18)F-PET/CT) scans in the diagnosis and early staging of non-mycosis fungoides/Sézary's syndrome cutaneous malignant lymphomas (non-MF/SS CML).

Materials And Methods: A total of 18 cases with non-MF/SS CML, confirmed by pathology or on clinical grounds, were analyzed in this study. The sensitivity of CT and PET/CT scans in the diagnosis of primary skin lesions, as well as the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of CT and PET/CT scans in the diagnosis of lymph nodes (LNs) and other organs (except skin and LNs) were calculated.

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Article Synopsis
  • - The study analyzed the effectiveness of PET/CT and MRI in diagnosing oropharyngeal non-Hodgkin's lymphoma (ONHL) using data from 30 patients who underwent both imaging exams within a two-week period.
  • - Findings revealed that the majority of ONHL cases were B-cell derived (76.7%), with common lesions presenting as masses or mixed types, and most showed high standardized uptake values (SUVmax) indicative of cancerous activity.
  • - The research concluded that both imaging modalities play a significant role in diagnosing ONHL and assessing the extent of the disease, particularly regarding lymph node involvement.
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  • The study aimed to analyze noninvasive imaging techniques, specifically arterial spin-labeling (ASL) and blood oxygen level-dependent (BOLD) imaging, for assessing kidney blood flow and oxygen levels in rats experiencing contrast-induced acute kidney injury (CIAKI).
  • Thirteen rats were divided into two groups and underwent ASL and BOLD imaging at various time points before and after receiving a contrast agent to monitor changes in renal blood flow (RBF) and oxygenation.
  • Results showed that RBF significantly decreased in specific kidney regions after exposure to the contrast agent, with some recovery observed later, highlighting that ASL and BOLD imaging can effectively track renal function changes in CIAKI.
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Purpose: To assess the impact of chest circumference (CC)-adjusted tube current and iterative reconstructions (iDose) on individualized radiation dose reduction and image quality (IQ) in ECG-triggered computed tomography coronary angiography (CTCA).

Materials And Methods: A total of 102 patients underwent retrospectively ECG-triggered CTCA utilizing CC-adapted tube current [mAs=1000×(0.051×CC-23.

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Objective: To confirm feasibility and assess intravoxel incoherent motion (IVIM) to differentiate active sacroiliitis and ankylosing spondylitis..

Methods: Forty-one patients were divided into two groups, an active group (n = 20) and a chronic group (n = 21), according to the Bath Ankylosing Spondylitis (AS) Disease Activity Index (BASDAI) and laboratory parameters.

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