Publications by authors named "Chang Ho Ryan Choi"
Background And Aims: Alterations in body composition are common in inflammatory bowel disease [IBD] and have been associated with differences in patient outcomes. We sought to consolidate knowledge on the impact and importance of body composition in IBD.
Methods: We performed a systematic search of MEDLINE, EMBASE and conference proceedings by combining two key research themes: inflammatory bowel disease and body composition.
Article Synopsis
- Patients with ulcerative colitis (UC) and low-grade dysplasia (LGD) are at a higher risk of developing advanced neoplasia (AN), such as high-grade dysplasia or colorectal cancer, highlighting the need for effective risk assessment.
- A study involving patients diagnosed with LGD from multiple UK centers used clinicopathological data to create a risk prediction model that was validated across additional cohorts, identifying key factors like the size of LGD, resection status, inflammation severity, and multifocality.
- The model's validated results indicate that patients meeting certain criteria can receive personalized risk assessments through a web tool, aiding in informed treatment decisions to potentially improve outcomes.
Objectives: Although chromoendoscopy is currently the recommended mode of surveillance in patients with long-standing ulcerative colitis, it is technically challenging and requires a long procedure time. The aim of this study was to compare the dysplasia detection rate of high-definition white light endoscopy with random biopsy (HDWL-R) vs high-definition chromoendoscopy with targeted biopsy (HDCE-T).
Methods: This was a multicenter, prospective randomized controlled trial involving 9 tertiary teaching hospitals in South Korea.
Objective: IBD confers an increased lifetime risk of developing colorectal cancer (CRC), and colitis-associated CRC (CA-CRC) is molecularly distinct from sporadic CRC (S-CRC). Here we have dissected the evolutionary history of CA-CRC using multiregion sequencing.
Design: Exome sequencing was performed on fresh-frozen multiple regions of carcinoma, adjacent non-cancerous mucosa and blood from 12 patients with CA-CRC (n=55 exomes), and key variants were validated with orthogonal methods.
Article Synopsis
- This study investigates the relationship between the inflammatory burden in ulcerative colitis (UC) and the risk of developing colorectal neoplasia (CRN) over time.
- It analyzed data from 987 patients with extensive UC over a median of 13 years, concluding that a cumulative inflammatory burden significantly correlates with CRN risk, rather than relying on the severity of inflammation from the most recent colonoscopy alone.
- The findings suggest that assessing multiple surveillance episodes is crucial for better risk stratification of CRN in patients with UC.
Objectives: The aim of this study was to identify risk factors associated with development of high-grade dysplasia (HGD) or colorectal cancer (CRC) in ulcerative colitis (UC) patients diagnosed with low-grade dysplasia (LGD).
Methods: Patients with histologically confirmed extensive UC, who were diagnosed with LGD between 1993 and 2012 at St Mark's Hospital, were identified and followed up to 1 July 2013. Demographic, endoscopic, and histological data were collected and correlated with the development of HGD or CRC.
Objectives: This study provides an overview of the largest and longest-running colonoscopic surveillance program for colorectal cancer (CRC) in patients with long-standing ulcerative colitis (UC).
Methods: Data were obtained from medical records, endoscopy, and histology reports. Primary end points were defined as death, colectomy, withdrawal from surveillance, or censor date (1 January 2013).
The authors present an unusual case of a 51-year-old man who developed relatively mild non-specific symptoms following intravesical BCG instillation for superficial transitional cell carcinoma of the bladder, with radiological investigations demonstrating typical features of miliary tuberculosis (TB). Transbronchial biopsy showed small foci of poorly formed granuloma suggestive of Mycobacterium infection. The patient's respiratory symptoms only became apparent 7 days after discharge having had 4 weeks of unremarkable inpatient stay where he remained clinically well.
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