Development and validation of a school satisfaction scale for medical students.

Objective: There is currently no widely accepted multidimensional School Satisfaction Scale (SSS) for Chinese medical students. To develop and validate the first SSS specifically for medical students in China. Our research sample is from China.

Glycemic variability and its association with short and long term clinical outcomes in critically ill patients with cerebral hemorrhage.

Cerebral hemorrhage is a major cause of mortality and disability. This study investigates the association between glycemic variability (GV) and short- and long-term clinical outcomes such as poor outcomes at discharge, mortality at 90 days and 1 year and intensive care unit (ICU) /hospital length of stay (LOS) in ICU patients with critically ill cerebral hemorrhage. This retrospective analysis examined 732 ICU patients with non-traumatic cerebral hemorrhage from the Medical Information Mart for Intensive Care (MIMIC)-IV database.

Individual and mixture effects of BTEX occupational exposure with hematologic and hepatic profiles in petrochemical workers and the metabolic mechanism.

Evidence on the association of occupational exposure to benzene, toluene, ethylbenzene, and xylene (BTEX) with hematologic and hepatic profiles were equivocal, and few studies have investigated overall effect of BTEX mixtures. Herein, significant higher concentrations (p < 0.05) of hippuric acid, 1,2-dihydroxybenzene, mandelic acid, trans, trans-muconic acid and phenylglyoxylic acid were found in petrochemical workers than the controls, in accordance with higher levels of hematologic and hepatic profiles found in petrochemical workers (p < 0.

VvARF19 represses VvLBD13-mediated cell wall degradation to delay softening of grape berries.

Fruit softening directly impacts its storage life, transportability, and customer acceptance. Auxin plays a key role during fruit ripening, but the underlying mechanisms of how auxin regulates fruit softening remain unclear. In this study, we investigated the regulatory roles of auxin on berry cell wall degradation during grape ( L.

Inhibition of Cullin3 Neddylation Alleviates Diabetic Retinopathy by Activating Nrf2 Signaling to Combat ROS-Induced Oxidative Stress and Inflammation.

Oxidative stress and inflammation induced by reactive oxygen species (ROS) play important roles in the development of diabetic retinopathy (DR). Nuclear factor erythroid 2-related factor 2 (Nrf2) signaling, which is negatively controlled by Cullin3-RING E3 ligase (CRL3) and controls ROS levels, is compromised in DR. CRL3 activity is regulated by Cullin3 neddylation.

Individualized Pooled CRISPR/Cas9 Screenings Identify CDK2 as a Druggable Vulnerability in a Canine Mammary Carcinoma Patient.

High-throughput omics approaches have long been used to uncover potential vulnerabilities in human personalized oncology but are often limited by the lack of functional validation. Therefore, we placed our emphasis on functional drug testing using patient-derived organoids (PDOs). However, PDOs generated from tumors mostly lack comparison with matching normal tissue, and the number of testable drugs is limited.

-Quinone methides in natural product synthesis: an update.

In recent years, -quinone methides have emerged as indispensable reactive species for enhancing synthetic efficiency in accessing various bioactive natural products. Importantly, the emulation of nature's patterns and strategies has yielded numerous refined synthetic pathways for the construction of intricate molecules. -Quinone methides (-QMs) have demonstrated remarkable versatility in organic synthesis, especially in strategies guided by biomimetic logic.

How does just culture reduce negative work outcomes through second victim distress and demand for support in clinical nurses? A path analysis.

Background: Second victim experiences of nurses are a critical issue in healthcare. In addition to causing psychological and emotional distress to nurses, second victim experiences can adversely affect organizational performance and overall patient safety.

Purpose: This study aimed to determine effects of perceived just culture of medical institutions on second victim experiences of nurses after patient safety incidents.

The causal association of Cardiometabolic diseases and Sepsis-related outcomes: A Mendelian randomization and population study.

Objective: The causality between CMD and sepsis has remained largely unknown. To elucidate this, we conducted a Mendelian randomization (MR) and population study.

Methods: Firstly, we used univariable and multivariable MR analyses to investigate causal associations between CMD and sepsis-related outcomes.

Atomically Dispersed Ta-O-Co Sites Capable of Mitigating Side Reaction Occurrence for Stable Lithium-Oxygen Batteries.

The side reactions accompanying the charging and discharging process, as well as the difficulty in decomposing the discharge product lithium peroxide, have been important issues in the research field of lithium-oxygen batteries for a long time. Here, single atom Ta supported by CoO hollow sphere was designed and synthesized as a cathode catalyst. The single atom Ta forms an electron transport channel through the Ta-O-Co structure to stabilize octahedral Co sites, forming strong adsorption with reaction intermediates and ultimately forming a film-like lithium peroxide that is highly dispersed.

Elaborate Designed Three-Dimensional Hierarchical Conductive MOF/LDH/CF Nanoarchitectures for Superior Capacitive Deionization.

Rational exploration of cost-effective, durable, and high-performance electrode materials is imperative for advancing the progress of capacitive deionization (CDI). The integration of multicomponent layered double hydroxides (LDHs) with conjugated conductive metal-organic frameworks (c-MOFs) to fabricate bifunctional heterostructure electrode materials is considered a complex but promising strategy. Herein, the fabrication of elaborately designed three-dimensional hierarchical conductive MOF/LDH/CF nanoarchitectures (M-CAT/LDH/CF) as CDI anodes via a controllable grafted-growth strategy is reported.

Visceral fat distribution: Interracial studies.

Visceral adipose tissue, a type of abdominal adipose tissue, is highly involved in lipolysis. Because increased visceral adiposity is strongly associated with the metabolic complications related with obesity, such as type 2 diabetes and cardiovascular disease, there is a need for precise, targeted, personalized and site-specific measures clinically. Existing studies showed that ectopic fat accumulation may be characterized differently among different populations due to complex genetic architecture and non-genetic or epigenetic components, ie, Asians have more and Africans have less visceral fat vs Europeans.

Urinary metabolic alterations associated with occupational exposure to metals and polycyclic aromatic hydrocarbons based on non-target metabolomics.

Long-term occupational exposure to metals and organics have been reported to be under great health risks. However, limited data are available on the molecular mechanism between combined exposure to metals and polycyclic aromatic hydrocarbons (PAHs) and harmful health effects. In present work, non-target metabolomics study was conducted based on urine samples from nonferrous metal smelting workers (n = 207), surrounding residents (n = 180), and the control residents (n = 187) by using ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS).

MicroRNA-mediated Ets1 repression in retinal endothelial cells: A novel anti-angiogenic mechanism in nonproliferative diabetic retinopathy.

Aims: This study aimed to discover the regulatory mechanisms contributing to angiogenesis in nonproliferative diabetic retinopathy (NPDR).

Materials And Methods: This study employed a case-control design involving type 2 diabetes patients with and without NPDR. We utilised microRNA sequencing to analyse plasma and retina samples from T2D patients, to identify both existing and novel microRNAs relevant to retinal health.

Electrochemical detection of extracellular vesicles for early diagnosis: a focus on disease biomarker analysis.

This review article presents a detailed examination of the integral role that electrochemical detection of extracellular vesicles (EVs) plays, particularly focusing on the potential application for early disease diagnostics through EVs biomarker analysis. Through an exploration of the benefits and challenges presented by electrochemical detection vetted for protein, lipid, and nucleic acid biomarker analysis, we underscore the significance of these techniques. Evidence from recent studies renders this detection modality imperative in identifying diverse biomarkers from EVs, leading to early diagnosis of diseases such as cancer and neurodegenerative disorders.

Inter- and intracellular mitochondrial communication: signaling hubs in aging and age-related diseases.

Mitochondria are versatile and complex organelles that can continuously communicate and interact with the cellular milieu. Deregulated communication between mitochondria and host cells/organelles has significant consequences and is an underlying factor of many pathophysiological conditions, including the process of aging. During aging, mitochondria lose function, and mitocellular communication pathways break down; mitochondrial dysfunction interacts with mitochondrial dyscommunication, forming a vicious circle.

Lnc_011797 promotes ferroptosis and aggravates white matter lesions.

Recent evidence suggests that ferroptosis plays a crucial role in the occurrence and development of white matter lesions. However, the mechanisms and regulatory pathways involved in ferroptosis within white matter lesions remain unclear. Long non-coding RNAs (lncRNAs) have been shown to influence the occurrence and development of these lesions.

Hydrous ferric arsenate transformation coupled with As, Fe, and S environmental cycling in sulfidic systems under anoxic and circumneutral conditions.

Despite many studies on the environmental cycling of As, Fe, and S, sulfide (S(-II))-induced hydrous ferric arsenate (HFA) transformation remains to be elucidated. Herein, we investigated the anaerobic reaction of HFA with S(-II) at three environmental concentrations (1, 10, and 50 mM) at pH 48. Changes in solid-phase As, Fe, and S speciation were investigated by XRD, FTIR, Raman, XPS, synchrotron XANES, SEM, and TEM.

Three-Dimensional Mesoporous Covalent Organic Framework for Photocatalytic Oxidative Dehydrogenation to Quinoline.

Developing precious metal-free catalysts for organic reactions under mild conditions is urgent. Herein, we report a three-dimensional covalent organic framework (3D-COF) with high crystallinity and permanent pores, termed 3D-TABPA-COF, for the oxidation of tetrahydroquinoline to quinoline. The 3D-TABPA-COF assembled based on ,-bis(4'-amino-[1,1'-biphenyl]-4-yl)-[1,1'-biphenyl]-4,4'-diamine (TABPA) is the catalytic active center for the conversion of tetrahydroquinoline.

PBLD enhances antiviral innate immunity by promoting the p53-USP4-MAVS signaling axis.

Phenazine biosynthesis-like domain-containing protein (PBLD) has been reported to be involved in the development of many cancers. However, whether PBLD regulates innate immune responses and viral replication is unclear. In this study, although it was found that the activity of PBLD extends to other PRRs, we focused on the RLR pathway activated via the p53-USP4-MAVS axis in response to virus infections.

An Yb(OTf)₃-Mediated Indirect Activation Strategy for the Stereoselective Synthesis of α-Sialosides from 2-Fluorosialyl Donors.

Most of chemical sialylation reactions are conducted at extremely low temperatures to achieve the formation of challenging sialic acid linkages with high stereoselectivities. Performing chemical sialylation at room temperature independent of enzymatic methods represents an effective approach, particularly significant in biological and biochemical research. Our study aims to develop a convenient method of providing α-sialyl glycosides.

Distribution, assessment, and causality analysis of soil heavy metals pollution in complex contaminated sites: a case study of a chemical plant.

To effectively prevent and control pollution from heavy metals (HMs) in urban soils, it is essential to thoroughly understand the contamination status of contaminated sites. In this study, the contamination status and sources of six HMs (As, Cu, Cr, Ni, Pb, Cd) in the soil of a decommissioned chemical plant in southern China were comprehensively analyzed. The results indicated that the average concentration of HMs followed the sequence: Cr > Pb > Cu > Ni > As > Cd.

Chicken GSDME, a major pore-forming molecule responsible for RNA virus-induced pyroptosis in chicken.

Pyroptosis is an inflammatory type of programmed cell death that mainly depends on the formation of plasma membrane pores by Gasdermin D (GSDMD) in mammals. However, the genetic deficiency of GSDMD in chicken renders avian pyroptosis elusive. Here, we show that infection of DF-1 cells (a chicken cell line) with infectious bursal disease virus (IBDV) induced cell death associated with chicken GSDME (chGSDME) cleavage, and so did cells with other RNA virus (VSV, AIV, or NDV) infections, indicating a broad role of chGSDME in RNA virus-induced pyroptosis in chicken.