Publications by authors named "Chanduni Syed"
Article Synopsis
- The study focuses on the management challenges of Takayasu arteritis (TAK) and examines the role of specific T-helper cells in the disease.
- Researchers compared blood samples from 21 TAK patients and 16 healthy controls, finding higher levels of certain memory T-helper cells (MDR1+ and CD161+) in TAK patients at baseline.
- After treatment, these T-helper cells decreased significantly only in patients who showed a positive response to therapy, suggesting a potential marker for treatment efficacy.
Article Synopsis
- The study examines the effects of different booster vaccines on immune responses in individuals who initially received either the ChAdOx1 nCov-19 or BBV152 vaccines, focusing on participants randomized into four groups for their booster shots.
- Results showed that ChAd boosted individuals exhibited higher memory-B cell frequencies and anti-spike IgG levels compared to those receiving the BBV152 booster, regardless of their primary vaccine.
- The findings also indicated that those in Group 3 (who received ChAd after two doses of BBV152) had a significantly better ability to inhibit the Omicron variant, suggesting the effectiveness of cross-boosting strategies in enhancing immune responses.
In low-resource settings, Cryptosporidium spp. is a common cause of diarrheal disease in children under the age of 3 years. In addition to diarrhea, these children also experience subclinical episodes that have been shown to affect growth and cognitive function.
View Article and Find Full Text PDFArticle Synopsis
- Researchers aimed to understand why oral vaccines, like the oral poliovirus vaccine (OPV), are less effective in low-income countries by analyzing immune responses in 292 infants from India.
- Despite measuring various immune factors, no specific immune profile was linked to the effectiveness of OPV, though higher stool viral pathogen presence was noted in infants who didn't respond to the vaccine.
- By using machine learning, they demonstrated that it's possible to predict vaccine response based on immune markers and infection status, achieving an accuracy of around 58%, but emphasized that better results may come from studying mucosal tissue more closely.