Megastigmane and hydroxybenzoic acid derivatives from aqueous leaves extract of lam.

The hot water extract of senescent leaves from is used in traditional Sri Lankan medicine for treating diabetes mellitus. This study aimed to isolate phytochemicals in the ethyl acetate soluble fraction of the hot water extract. Bioassay-guided fractionation led to the isolation of three megastigmane derivatives and two hydroxybenzoic acid derivatives from fractions, demonstrating both hypoglycaemic and antidiabetic activities.

Cellular localisation and quantification of Camptothecin in different plant parts of Nothapodytes nimmoniana (J. Graham) Mabberley of Sri Lankan origin.

Introduction: Nothapodytes nimmoniana (Icacinaceae) is a rich source of Camptothecin (CPT), an anti-cancer prodrug. Efficient extraction of CPT from various plant parts is crucial for better recovery of this pre-drug.

Objectives: To investigate the distribution of CPT in plant parts and to compare the methods of extraction on CPT yield to evaluate how cellular localisation affects the efficiency of extraction methods.

Nutritive Importance and Therapeutics Uses of Three Different Varieties (, , and ) of Curry Leaves: An Updated Review.

, () are three varieties of curry leaves in the family Rutaceae. They have been widely used in Ayurvedic medicine worldwide in the treatment and prevention of various diseases. Earlier findings provide strong evidence to support the three curry leaf species' potent pharmaceutical and biological effects, including antioxidant, antidiabetic, anti-inflammatory, and antitumor activities.

Phytochemical screening, total polyphenol, flavonoid content, antioxidant and antibacterial activities of Sri Lankan varieties of and leaves.

The use of plant materials in traditional medicine as a significant ingredient in synthesizing drugs in the form of decoctions had played a vital role due to their potential therapeutic action. The curry leaves, , and are two most common aromatic herbs widespread in Sri Lanka and many other Asian countries. They are rich in nutrition and exert several medicinal properties such as antidiabetic, antioxidant, antimicrobial, anti-inflammatory, and anti-carcinogenic due to various essential phytochemicals, minerals, and trace minerals.

F18 a new source of camptothecin-producing endophytic fungus from growing in Sri Lanka.

An endophytic fungus producing camptothecin (CPT) was isolated from the leaf of (Sri Lanka), and culture conditions were optimised to enhance the yield of CPT. The TLC, HPLC-PDA, LC-MS/MS and spectroscopic data were used to identify and quantify CPT. Solvent extraction (chloroform: methanol 4:1 v/v) of submerged cultures in Sabouraud Dextrose Broth (SDB) detected CPT in the mycelial extract but not in the culture broth.

Acute anti-inflammatory and anti-nociceptive activities of crude extracts, alkaloid fraction and evolitrine from Acronychia pedunculata leaves.

Ethnopharmacological Relevance: Acronychia pedunculata (family: Rutaceae) is one of the commonly used medicinal plants in Sri Lankan traditional medicine. Different parts of this plant are used for the treatment of inflammatory conditions in the form of medicinal oils and herbal porridge.

Aim Of The Study: The present study aimed to evaluate the anti-nociceptive activity and anti-inflammatory activity with their mechanisms and the acute toxicity of crude extracts of the fresh leaves of A.

Gotu Kola (Centella asiatica): Nutritional Properties and Plausible Health Benefits.

Centella asiatica L. (Gotu Kola) is a nutritionally important plant and a valued traditional medicine in South East Asia. In this review, the chemical composition, nutritional values, and health benefits of C.

Pressure compensated fiber laser hydrophone: modeling and experimentation.

A pressure compensated metal diaphragm based fiber laser hydrophone configuration that can provide good sensitivity, large bandwidth, and sea state zero noise floor is proposed in this paper. A simplified theoretical model of the proposed sensor configuration is developed in which the acoustic elements of the sensor configuration are modeled using a four-pole acoustic transfer matrix and the structural elements are modeled as second order single degree of freedom elements. This model is then used to optimize the design parameters of the sensor system to achieve the performance objectives.

Carotenoid and mineral content of different morphotypes of Centella asiatica L. (Gotukola).

Six morphotypes of Centella asiatica designated G(1), G(2), G(3), G(7), G(8) and G(12) were analyzed for carotenoid content, proximate components and selected dietary minerals. Potassium was found to be the major element present in C. asiatica and the content in G(1) and G(3) (6,165.

Carotenoid content and in vitro bioaccessibility of lutein in some leafy vegetables popular in Sri Lanka.

Lutein is one of the major carotenoids in green leafy vegetables (GLVs), which show a marked antioxidant activity. The study was carried out to identify and quantify the carotenoid content of selected Sri Lankan GLVs. RP-HPLC with photodiode array detection method was followed for the separation, identification and quantification of carotenoids.

Antioxidant and antibacterial activities on foodborne pathogens of Artocarpus heterophyllus Lam. (Moraceae) leaves extracts.

Total water extract, ethyl acetate, and aqueous fractions from the leaves of Artocarpus heterophyllus were evaluated for phenolic content, antioxidant, and antibacterial activities against some foodborne pathogens such as E. coli, Listeria monocytogenes, Salmonella typhimurium, Salmonella enterica, Bacillus cereus, Enterococcus faecalis, and Staphylococcus aureus. The minimum inhibitory concentration (MICs) of extract and fractions determined by the agar dilution method were ranged from 221.

Carotenoid content and in vitro bioaccessibility of lycopene from guava (Psidium guajava) and watermelon (Citrullus lanatus) by high-performance liquid chromatography diode array detection.

The carotenoid content and in vitro accessibility of the 'Sugar baby' variety of watermelon and the 'Horana red' variety of guava from Sri Lanka was determined using high-performance liquid chromatography. The high-performance liquid chromatography chromatogram showed that the Guava 'Horana red' variety contained almost exclusively lycopene (45.3 +/- 8.

Content and in-vitro accessibility of pro-vitamin A carotenoids from Sri Lankan cooked non-leafy vegetables and their estimated contribution to vitamin A requirement.

Vitamin A deficiency is a public health problem in Sri Lanka, which affects especially pre-school children. Carrots (Daucus carota), pumpkins (Cucurbita maxima), squashes (Cucurbita moschata) and sweet potatoes (Ipomoea batatas) of orange, yellow-fleshed varieties are good sources of provitamin A carotenoids, but have not been studied in Sri Lanka in terms of the food as eaten. The content of carotenoids in each preparation method and the in-vitro accessibility of beta-carotene and alpha-carotene were determined by high-performance liquid chromatography.

Evaluation of the effectiveness of the national vitamin A supplementation programme among school children in Sri Lanka.

The Ministry of Health in Sri Lanka commenced a vitamin A supplementation programme of school children with a megadose of 105 micromol (100,000 IU) vitamin A in school years 1, 4 and 7 (approximately 5-, 9- and 12-year-olds, respectively) in 2001. We evaluated the vitamin A supplementation programme of school children in a rural area of Sri Lanka. A cross-sectional study was conducted among children supplemented with an oral megadose of vitamin A (105 micromol; n 452) and children not supplemented (controls; n 294) in Grades 1-5.

Impact of vitamin A supplementation on health status and absenteeism of school children in Sri Lanka.

The objective of this study was to determine the impact of Vitamin A supplementation on health status and absenteeism of school children. A randomized double blind placebo controlled trial over a period of 13 months was conducted in a rural area of Sri Lanka involving 613 school children attending Grades 1-5 (aged 5 to 13 years). Children were assigned to either 200,000 IU of Vitamin A (n=297) or placebo (n=316) once every 4 months.