Clinical predictors of drug nonresponse in obsessive-compulsive disorder.

Objective: Obsessive-compulsive disorder (OCD) is often a chronic and disabling illness with high comorbidity. Serotonin reuptake inhibitors (SRIs) are effective in treating OCD. However, 40% to 60% of patients with OCD do not respond adequately to SRIs.

An 11- to 13-year follow-up of 75 subjects with obsessive-compulsive disorder.

Objective: There is a paucity of data on the long-term course and outcome of obsessive-compulsive disorder (OCD). Available data suggest that OCD runs a chronic course with waxing and waning severity. However, most previous studies included severely ill patients who were often clinically referred and hospitalized.