Arterial switch for double-outlet left ventricle - Diagnostic and surgical considerations.

Double-outlet left ventricle (DOLV) is a rare congenital cardiac anomaly in which both the aorta and pulmonary artery arise completely or predominantly from the left ventricle. DOLV is a spectrum and can be classified depending on the position of the ventricular septal defect (VSD) relative to the great vessels, the relationship of the great vessels, and the presence or absence of pulmonary or aortic outflow obstruction. In the absence of tricuspid atresia or hypoplastic right ventricle, two ventricle repair is the preferred surgical treatment.

Combined Warden and Mustard procedure for late presenting transposition with anomalous pulmonary venous connections and regressed left ventricle.

The presence of systemic and pulmonary venous anomalies in late presenting transposition of great arteries (TGA) may make standard atrial switch procedures difficult, necessitating modification in the surgical procedure. We present a case report of a 13-year-old boy with a partial anomalous connection of right superior pulmonary vein with TGA and regressed left ventricle, where a combination of Warden procedure and Mustard procedure was used.

Efficacy of Government-Sponsored Community Health Programs for Older Adults: A Systematic Review of Published Evaluation Studies.

Population aging is an ongoing challenge for global health policy and is expected to have an increasing impact on developing economies in years to come. A variety of community health programs have been developed to deliver health services to older adults, and evaluating these programs is crucial to improving service delivery and avoiding barriers to implementation. This systematic review examines published evaluation research relating to public and community health programs aimed at older adults throughout the world.

Current perspective of immunomodulators for lung transplant.

Lung transplantation is an effective treatment option for selected patients suffering from end-stage lung disease. More intensive immunosuppression is enforced after lung transplants owing to a greater risk of rejection than after any other solid organ transplants. The commencing of lung transplantation in the modern era was in 1983 when the Toronto Lung Transplant Group executed the first successful lung transplant.

Geochemical and isotope tracing of groundwater salinity in the coastal Gujarat alluvial plain, India.

This study attempts to learn the groundwater salinization mechanism in the large and well-populated coastal Gujarat alluvial plain under growing anthropogenic pressures. For this purpose, geochemical compositions and Sr/Sr were analyzed in 53 groundwater samples collected in the three different seasons during 2016-2017. Additionally, surface water samples collected in each season from two nearby large rivers (Narmada and Tapi) and urban sewage discharge of Surat city were also analyzed.

Scaling skin and failing heart: the cardio-cutaneous connection.

Ichthyosis refers to a comparatively rare group of skin disorders which may present with associated cardiomyopathy. We report a case of an 11-year-old female child who presented with ichthyosis and associated dilated cardiomyopathy. Genetic testing revealed mutation in the RBCK1 gene.

Inter-estuarine and seasonal to decadal variations of heavy metal pollution in the Gulf of Cambay, India.

Toxic heavy metals adsorbed preferentially onto suspended sediments enter our food chain by bio-assimilation in coastal ocean organisms. To decipher metal pollution status in the Gulf of Cambay (food hub of India) under rising anthropogenic pressure, we present seasonal abundances of Ti, Cr, Co, Ni, Cu, Zn, Cd, and Pb in > 150 samples of suspended sediments (> 0.45 µm) collected in four seasons (2016-2017) from two large estuaries (Narmada and Tapi).

Heart transplantation for patients with single ventricle physiology.

Background: There is a growing population of palliated and unpalliated single ventricle physiology patients for whom heart transplantation is the only treatment option available. There is a paucity of reports of heart transplantation in this challenging and growing subset of patients from our part of the world. The purpose of the article is to briefly review our experience in the subgroup and compare it with the available literature.

Effect of Blood Group on Ultrahigh Frequency Auditory Sensitivity.

 Individuals with blood group O are reported to have reduced otoacoustic emissions (OAEs) compared with individuals with different blood groups.  The present study attempted to determine if the blood group has any effect on high-frequency auditory sensitivity using ultrahigh-frequency audiometry and ultrahigh-frequency distortion product otoacoustic emissions (DPOAEs).  High-frequency thresholds and high-frequency DPOAEs were measured in 60 individuals with normal hearing and different blood groups.

Nanosized complexation assemblies housed inside reverse micelles churn out monocytic delivery cores for bendamustine hydrochloride.

Objective: We explore a plausible method of targeting bendamustine hydrochloride (BM) to circulatory monocytes by exploiting their intrinsic endocytic/phagocytic capability.

Methods: We do so by complexation of sodium alginate and chitosan inside dioctyl sulfo succinate sodium (AOT) reverse micelles to form bendamustine hydrochloride loaded nanoparticles (CANPs). Dynamic light scattering, electrophoretic mobility and UV spectroscopy were used to detail intra-micellar complexation dynamics and to prove that drug was co-captured during interaction of carbohydrate polymers.

Manual liquid based cytology in primary screening for cervical cancer--a cost effective preposition for scarce resource settings.

Conventional pap smear (CPS) examination has been the mainstay for early detection of cervical cancer. However, its widespread use has not been possible due to the inherent limitations, like presence of obscuring blood and inflammation, reducing its sensitivity considerably. Automated methods in use in developed countries may not be affordable in the developing countries due to paucity of resources.