Inflammatory Myofibroblastic Tumor Masquerading as Congenital Pelvic-ureteric Junction Obstruction.

Inflammatory myofibroblastic tumor (IMT) is a very rare tumor with still rare occurrence in the genitourinary system, presenting as a pelvic-ureteric junction (PUJ) obstruction (PUJO). We report a case of IMT at the PUJ mimicking congenital PUJO and review the relevant literature.

Cruise set to restore critical Indian Ocean mooring array.

Mostly inoperable since 2020, sensors are key to monsoon forecasts and understanding global climate patterns.

Insights into the Emerging Therapeutic Targets of Triple-negative Breast Cancer.

Triple-negative Breast Cancer (TNBC), the most aggressive breast cancer subtype, is characterized by the non-appearance of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Clinically, TNBC is marked by its low survival rate, poor therapeutic outcomes, high aggressiveness, and lack of targeted therapies. Over the past few decades, many clinical trials have been ongoing for targeted therapies in TNBC.

Novel Antitubercular Agents: Design, Synthesis, Molecular Dynamic and Biological Studies of Pyrazole - 1,2,4-Triazole Conjugates.

Mycobacterium tuberculosis (Mtb) has numerous cell wall and non-cell wall mediated receptors for drug action, of which cell wall mediated targets were found to be more promising because of their pivotal role in bacterial protection and survival. Herein, we reported the design and synthesis of a series of pyrazole-linked triazoles based on the reported structural features of promising drug candidates that target DprE1 receptors through a Structure-based drug design (SBDD) approach (6a-6j and 7a-7j). The synthesized compounds were evaluated for their in-vitro antitubercular activity against virulent strains of Mtb H37Rv.

Hematuria in an Adolescent Boy With Long-Standing Prostatic Utricle Cyst-An Ominous Sign.

The prostatic utricle cyst is usually an asymptomatic enlargement of the persistent remnant of Mullerian duct in males, especially seen associated with hypospadias and usually needs no active intervention. However occasionally they can become symptomatic and can present with complaints of impotence, ejaculatory pain, difficult voiding, urinary retention and abdominal pain. Hematuria is a rare symptom in such patients and is usually due to infection.

Concealed Penile Duplication - Presenting Late.

We report a case of concealed penile duplication without many symptoms and normally looking external genitalia in a 10-year-old boy. He was evaluated with appropriate imaging and had successful surgical reconstruction of his genitalia with good cosmesis and functional outcome.

Melanotic Neuroectodermal Tumor of Infancy: Does Enucleation Alone Suffice?

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare melanin-containing mesenchymal tumor of neural crest origin. We present a case of MNTI in a 1-year-old girl. It was managed successfully with conservative excision (enucleation).

The case for the use of telehealth for abortion in India.

India has the world's fastest growing outbreak of COVID-19. With limited mobility, increased reports of intimate partner violence, changes in living patterns of migrants, delays in accessing contraception and safe abortion care, and potential changes to decisions about parenting, there may be an increased need for abortion services in India due to the pandemic. The use of technology for providing abortion information and services has been well documented in global literature.

Acquired antibody responses against merozoite surface protein-1 antigen during and infections in South Indian city of Mangaluru.

Merozoite surface protein-1 (MSP-1) of malaria parasites has been extensively studied as a malaria vaccine candidate and the antibody response to this protein is an important indicator of protective immunity to malaria. Mangaluru city and its surrounding areas in southwestern India are endemic to malaria with being the most widespread and prevalent species although also frequently infects. However, no information is available on the level of protective immunity in this population.

How Reliable Is Automated Urinalysis in Acute Kidney Injury?

Objective: Examination of urine sediment is crucial in acute kidney injury (AKI). In such renal injury, tubular epithelial cells, epithelial cell casts, and dysmorphic red cells may provide clues to etiology. The aim of this study was to compare automated urinalysis findings with manual microscopic analysis in AKI.

Recurrent genetic abnormalities detected by FISH in adult B ALL and association with hematological parameters.

Background: Recurrent genetic abnormalities influence prognosis in B lymphoblastic leukemia. BCR-ABL rearrangement is associated with higher leukocyte counts and older age at presentation. Among adults, BCR -ABL - is the commonest recurrent abnormality whereas, IgH rearrangements are rare.

EGFR mutations and ROS1 and ALK rearrangements in a large series of non-small cell lung cancer in South India.

Background: Driver mutations are seen in 80% of lung adenocarcinomas, and they influence prognosis and choice of therapy.

Aim: Aim of this study was to analyse the frequency of epidermal growth factor receptor (EGFR) mutations, ALK and ROS1 rearrangements and their association with age and gender in non-small cell lung cancer reported from a tertiary care center in South India.

Methods: Tumors from patients with non-small cell carcinoma of lung were evaluated for EGFR mutations, ALK and ROS1 rearrangements and their association with age and gender were studied.

Surveillance of neo-squamous epithelium after ablation of Barrett's esophagus: is it better to use jumbo over standard biopsy forceps?

Background And Aims: As obtaining adequate tissue on biopsy is critical for the detection of residual and recurrent intestinal metaplasia/dysplasia in Barrett's esophagus (BE) patients undergone Barrett's endoscopic eradication therapy (BET), we decided to compare the adequacy of biopsy specimens using jumbo versus standard biopsy forceps.

Methods: This is a two-center study of patients' post-radiofrequency ablation of dysplastic BE. After BET, jumbo (Boston Scientific©, Radial Jaw 4, opening diameter 2.

Clinical features and haematological parameters among malaria patients in Mangaluru city area in the southwestern coastal region of India.

The aim of this study was to assess the clinical profile, severity and complications of patients suffering from malaria in Mangaluru, a southwestern coastal city in India. A total of 579 patients, who were treated at the District Wenlock Hospital, Mangaluru, and 168 healthy controls were recruited in this study. The clinical profile, haematological and biochemical parameters, and disease complications were assessed.

Association between Inflammatory Cytokine Levels and Thrombocytopenia during and Infections in South-Western Coastal Region of India.

Background: Thrombocytopenia is a most commonly observed complication during malaria infections. Inflammatory cytokines such as IL-1, IL-6, and IL-10 have been documented in malaria induced thrombocytopaenia. This study was aimed to understand the possible relationship between inflammatory cytokines across varying degrees of thrombocytopenia during , and mixed infections.

Malaria Severity in Mangaluru City in the Southwestern Coastal Region of India.

Dakshina Kannada district in the Southwestern region of Karnataka state, India, including Mangaluru city is endemic to malaria. About 80% of malaria infections in Mangaluru and its surrounding areas are caused by and the remainder is due to . Malaria-associated clinical complications significantly occur in this region.

Can Platelet Distribution Width Be Used to Predict the Possibility of Chronic Myeloproliferative Neoplasms?

Platelet distribution width (PDW) and mean platelet volume are markers of platelet activation and have prognostic value in coronary heart diseases, as well as in cancers of solid organs. In this study, we evaluated the possibility of using PDW to predict chronic myeloproliferative neoplasms by comparing platelet indices obtained by automated analyzers in chronic myeloproliferative neoplasms with those in control specimens. We found that PDW greater than 66.

Improved contrast microscopy: modification of bright field for urine sediment visualisation.

Background: Phase contrast microscopy is the recommended technique for urine sediment examination. Bright field microscopy does not differentiate objects with slight changes in the refractive index and hence phase contrast is a superior alternative.

Methods: In this article, we describe a novel method to improve contrast in bright field microscopy.

Malaria prevalence in Mangaluru city area in the southwestern coastal region of India.

Background: Malaria is highly prevalent in many parts of India and the Indian subcontinent. Mangaluru, a city in the southwest coastal region of Karnataka state in India, and surrounding areas are malaria endemic with 10-12 annual parasite index. Despite high endemicity, to-date, very little has been reported on the epidemiology and burden of malaria in this area.

Cytogenetic Profiling of Myelomas, Association With Complete Blood Count: Study of 180 Patients.

Objectives: To analyze the most common primary and secondary cytogenetic events in myelomas using a probe panel designed in our laboratory, and to associate those events with hematological and biochemical findings.

Methods: Blood specimens from patients diagnosed with myeloma were processed to determine complete blood count and levels of albumin, creatinine, and beta-2 microglobulin. We evaluated bone-marrow specimens for plasma-cell percentage by light microscopy and for cytogenetic abnormalities by fluorescence in situ hybridization (FISH).

Association between QTd, Tp-e/QT Ratio and In-hospital Prognosis in Thrombolysed Acute ST-elevation Myocardial Elevation (STEMI) Patients.

Background: Both QTd and Tp-e/QT ratio have been linked to increased risk for arrhythmia and mortality. But Significance of QTd in STEMI Patients is not documented in all studies and Tp-e/QT ratio is a novel index which is understudied in these patients. Therefore, the present study is aimed to determine the short term, in-hospital prognostic value of QTd and Tp-e/QT ratio in thrombolysed STEMI patients.

Simplified Method for Local Correction of System International Normalized Ratio.

Background: International normalized ratio (INR) derivation is dependent on the international sensitivity index (ISI) of thromboplastin. It varies with instrument and reagents used.

Objective: To evaluate the role of a correction factor in the derivation of INR.

Substituted Benzamides from Anti-inflammatory and p38 Kinase Inhibitors to Antitubercular Activity: Design, Synthesis and Screening.

Background: Twenty one amide compounds possessing phenoxy/benzyloxy/pyridinyl groups have been synthesized by benzoylation of respective amines in presence of base with moderate to encouraging yields. Upon confirmation of structure, compounds were subjected for p38 kinase inhibitory, anti-inflammatory, antimicrobial and antitubercular activities.

Method: Anti-inflammatory activity was determined using carrageenan induced rat paw edema model while p38 kinase inhibitory activity was studied using ELISA method and serial dilution method was employed to determine MICs.