Changing Treatment and Metastatic Disease Patterns in Patients with EGFR Mutated NSCLC: An Academic Thoracic Medical Investigator's Consortium Registry Analysis.

Introduction: Osimertinib is now a standard first-line (1L) therapy for EGFR-mutated (EGFRm) advanced NSCLC. We aimed to characterize patterns of therapy and longitudinal risk of brain and liver metastasis in a cohort of EGFRm NSCLC.

Methods: Patients with metastatic EGFRm NSCLC who received 1L systemic therapy at sites within the Academic Thoracic Medical Investigator's Consortium were included; demographic and clinical data including treatment patterns were described.

Characteristics of Long-Term Survivors With EGFR-Mutant Metastatic NSCLC.

Introduction: Characteristics of long-term survivors in EGFR-mutant (EGFRm) NSCLC are not fully understood. This retrospective analysis evaluated a multi-institution cohort of patients with EGFRm NSCLC treated in the pre-osimertinib era and sought to describe characteristics of long-term survivors.

Methods: Clinical characteristics and outcomes were abstracted from the electronic medical records of patients with EGFRm metastatic NSCLC who started first-line therapy before 2015.

The response of the frugivorous lion-tailed macaque (Macaca silenus) to a period of fruit scarcity.

Tropical rainforests show seasonal fluctuations in the abundance of fruits resulting in periods of resource scarcity for frugivores. We examined the response of an obligate frugivore, the lion-tailed macaque (LTM) (Macaca silenus), to a period of fruit scarcity in a rainforest in the Western Ghats, India. We estimated the abundance and distribution of fruit resources from food tree densities obtained from 348 point centered quadrats, and fruit availability from phenological monitoring of 195 trees of 15 reported major food species.

Progress in the research of artemisinin and its analogues as antimalarials: an update.

Malaria is the number one infectious disease in the world today. Worldwide, over two million people die each year from malaria. This shocking reality is largely due to the emergence of drug resistant strains of Plasmodium falciparum.

Spontaneous rupture of the stomach.

A case of spontaneous rupture of the stomach associated with perforation of the diaphragm is reported. Spontaneous rupture of the stomach is a rare but fatal condition. The pathophysiologic features, clinical manifestations, and treatment are discussed.

Diffuse muscular hypertrophy of esophagus.

Six cases of diffuse muscular hypertrophy of the esophagus are reported. The clinical diagnosis is often missed and may be confused with achalasia. Some clinical features that help distinguish this disease are a sensation of "grasping" any tube or instrument introduced into the esophagus, marked sustained elevation in the baseline pressure in the body of the esophagus over a longer segment, and poor response to forced pneumatic dilatation (in those cases in which achalasia is suspected).

Obstructive jaundice due to radiation-induced hepatic duct stricture.

A case of obstructive jaundice due to radiation-induced hepatic duct stricture is reported. The patient received postoperative radiation for left adrenal carcinoma, seven years prior to this admission. The sequelae of hepatobiliary radiation and their management are discussed briefly.

Foreign body perforation of the stomach.

A case of foreign body perforation of the stomach is reported. Complications of foreign bodies in the gastrointestinal tract and their management are discussed.

Endoscopic retrieval of an unusual gastric foreign body.

A case of endoscopic retrieval of a gastric foreign body, retained due to peptic ulcer disease, is reported. An Olympus polypectomy snare was used to extract the foreign body. The role of endoscopy in the management of an upper gastrointestinal tract foreign body is discussed.

Leukopenia with cimetidine.

A case of leukopenia associated with cimetidine therapy is reported. The patient had sarcoid cirrhosis with portal hypertension. Cimetidine therapy was instituted for upper gastrointestinal bleeding due to gastritis, resulted in leukopenia, and was reversed on discontinuation of therapy.

Small bowel obstruction due to gaseous distention of an intestinal balloon.

A case of small bowel obstruction caused by inflation of a sealed, mercury-filled finger cot tipped feeder catheter, used for enteral alimentation, is reported. The patient had infrapapillary duodenal obstruction, secondary to the intramural hematoma caused by blunt abdominal injury. The patient underwent surgery for the obstruction and the distended finger cot was decompressed.