Publications by authors named "Chandrasekaran Padmapriyadarshini"
Background: Earlier serosurveys in India revealed seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) of 0.73% in May-June 2020 and 7.1% in August-September 2020.
View Article and Find Full Text PDFBackground: More than 20% of tuberculosis (TB) disease worldwide may be attributable to smoking and alcohol abuse. India is the second largest consumer of tobacco products, a major consumer of alcohol particularly among males, and has the highest burden of TB globally. The impact of increasing tobacco dose, relevance of alcohol misuse and past versus current or never smoking status on TB treatment outcomes remain inadequately defined.
View Article and Find Full Text PDFDespite substantial exposure to infectious pulmonary tuberculosis (TB) cases, some household contacts (HHC) never acquire latent TB infection (LTBI). Characterizing these "resisters" can inform who to study immunologically for the development of TB vaccines. We enrolled HHCs of culture-confirmed adult pulmonary TB in India who underwent LTBI testing using tuberculin skin test (TST) and QuantiFERON TB Gold Test-in-tube (QFT-GIT) at baseline and, if negative by both (<5mm TST and <0.
View Article and Find Full Text PDFBackground: The relationships between first-line drug concentrations and clinically important outcomes among patients with tuberculosis (TB) remain poorly understood.
Methods: We enrolled a prospective cohort of patients with new pulmonary TB receiving thrice-weekly treatment in India. The maximum plasma concentration of each drug was determined at months 1 and 5 using blood samples drawn 2 hours postdose.
Paradoxical tuberculosis immune reconstitution inflammatory syndrome (TB-IRIS) in HIV patients with culture confirmed pulmonary tuberculosis in India and the potential role of IL-6 in prediction.
PLoS One
December 2013
Article Synopsis
- The study investigated the incidence and clinical predictors of paradoxical TB-IRIS in HIV-positive patients with confirmed pulmonary tuberculosis in India, which had not been done prospectively before.
- Patients on anti-tuberculosis therapy were monitored after starting antiretroviral therapy, revealing that over half experienced IRIS events, often requiring corticosteroids for treatment.
- Key predictors for IRIS included lower CD4(+) T-cell counts and higher baseline levels of IL-6 and CRP, suggesting these markers could help forecast IRIS occurrences.