Anti-diarrhoeal activity of a polyherbal formulation in rats and elucidation of its cellular mechanisms.

Objective: The present study was aimed to study anti-diarrhoeal activity of a polyherbal formulation (PHF) in rats and elucidate its mechanism of action.

Materials And Methods: Anti-diarrhoeal activity of PHF was investigated using castor oil-induced diarrhoea, small intestinal transit and enteropooling models in rats. PHF was tested at 75, 150 and 300 mg/kg rat body weight.

Polar extract of Curcuma longa protects cartilage homeostasis: possible mechanism of action.

Background: Curcuma longa has been well documented for managing joint inflammation and pain. The present study investigated the effect of polar extract of C. longa (NR-INF-02) on cartilage homeostasis in human articular chondrocytes knee (NHAC-kn) cells to understand its plausible mechanism of action.

Bioactive Turmerosaccharides from Extract (NR-INF-02): Potential Ameliorating Effect on Osteoarthritis Pain.

Background: has long history of medicinal use in Ayurveda. A unique product NR-INF-02 was prepared from that was standardized to contain turmerosaccharides.

Objective: The present study investigated the effect of turmerosaccharides rich fraction of NR-INF-02 on monosodium iodoacetate (MIA)-induced OA pain animal model that mimics human OA.

Is extract and andrographolide anaphylactic?

is a popularly known medicinal plant extensively used in many parts of the world for treatment of various diseases. Since recent past, anaphylactic/allergic type adverse events were reported upon usage, the study aimed to evaluate the anaphylactic and anaphylactoid potential of extract and andrographolide (a major phytoactive of ). The anaphylactic potential was evaluated using active systemic anaphylaxis (ASA) assay in guinea pigs.

Anti-stress Activity of Ocimum sanctum: Possible Effects on Hypothalamic-Pituitary-Adrenal Axis.

The present study investigated anti-stress potential of Ocimum sanctum in chronic variable stress (CVS) paradigm. Further, the possible mechanism of anti-stress was explored in vitro using cell and cell-free assays. Rats were administered O.

Safety evaluation of turmeric polysaccharide extract: assessment of mutagenicity and acute oral toxicity.

Curcuma longa Linn. (Zingiberaceae) commonly known as turmeric has long been used for centuries as a spice and household remedy. The present study was carried out to assess the possible mutagenic potential and acute oral toxicity of polysaccharide extract of turmeric rhizome (NR-INF-02) using standard tests.

Effect of Nelumbo nucifera Petal Extracts on Lipase, Adipogenesis, Adipolysis, and Central Receptors of Obesity.

N. nucifera is one among the important medicinal plants assessed for its antiobesity action in various preclinical models. The present study was aimed at investigating the antiobesity effect of methanol and successive water extracts of petals of N.