Publications by authors named "Chandrasekar Narayanan Rahul"
Article Synopsis
- - Recent research shows that amino acid repeats are linked to various diseases and impact the development of disordered protein regions.
- - Existing algorithms for analyzing these repeats have limitations, such as restrictions on repeat length and the number of protein sequences that can be analyzed.
- - The new method, ISRMPS, allows for identification of identical and distantly located repeats in multiple protein sequences, useful for studying evolution, epitope mapping, and CRISPR-Cas sequencing.
To regulate biological activity in humans, the Notch signaling pathway (NSP) plays an essential role in a wide array of cellular development and differentiation process. In recent years, many studies have reported that aberrant activation of Notch is associated with the tumor process; but no appropriate database exists to fill this significant gap. To address this, we created a pioneering database NCSp, which is open access and comprises intercommunicating pathways and related protein mutations.
View Article and Find Full Text PDFScreening of FDA-approved compound library identifies potential small-molecule inhibitors of SARS-CoV-2 non-structural proteins NSP1, NSP4, NSP6 and NSP13: molecular modeling and molecular dynamics studies.
J Proteins Proteom
June 2021
Unlabelled: COVID-19, the current global pandemic has caused immense damage to human lives and the global economy. It is instigated by the SARS-CoV-2 virus and there is an immediate need for the identification of effective drugs against this deadly virus. SARS-CoV-2 genome codes for four structural proteins, sixteen non-structural proteins (NSPs) and several accessory proteins for its survival inside the host cells.
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