Synergistic effects of plastic debris and elevated nitrate concentrations on the proliferation of Ulva lactuca micro-propagules.

Ulva lactuca is a versatile intertidal and blooming green macroalga with a global distribution, undergoing a lifecycle that consists of critical phases. The effects of surface physical properties and elevated nitrate concentrations on the growth of Ulva spores were evaluated using ATR-FTIR analysis, water contact angle measurements and fluorescence microscopy. The weathering process conducted with seawater led to the emergence of new functional groups such as CO, CH (rock), and CH, alongside a reduction in existing groups on the polymers, as evidenced by ATR-FTIR.

Rasch analysis of quality of life in children with vernal keratoconjunctivitis (QUICK) questionnaire.

Clinical Relevance: A validated questionnaire measures the construct accurately, helps clinician to support decision making, facilitates assessment and monitoring of patients, guides clinical trial and promotes patient-centred care.

Background: To assess the psychometric properties of the Quality of Life in Children with Vernal Keratoconjunctivitis (QUICK) questionnaire among Indian children with Vernal Keratoconjuntivitis (VKC) using Rasch analysis.

Methods: This study used a questionnaire validation study design.

Making the most of big qualitative datasets: a living systematic review of analysis methods.

Introduction: Qualitative data provides deep insights into an individual's behaviors and beliefs, and the contextual factors that may shape these. Big qualitative data analysis is an emerging field that aims to identify trends and patterns in large qualitative datasets. The purpose of this review was to identify the methods used to analyse large bodies of qualitative data, their cited strengths and limitations and comparisons between manual and digital analysis approaches.

Effectiveness of WhatsApp based debunking reminders on follow-up visit attendance for individuals with hypertension: a randomized controlled trial in India.

Background: Individuals with high blood pressure in India often miss essential follow-up visits. Missed visits contribute to gaps across the hypertension care continuum and preventable cardiovascular disease. Widespread misconceptions around hypertension care and treatment may contribute to low follow-up attendance rates, but to date, there is limited evidence of the effect of interventions to debunk such misconceptions on health-seeking behavior.

mHealth interventions for postpartum family planning in LMICs: A realist review.

The unmet need for family planning is a pervasive public health concern in many low- and middle-income countries (LMICs). Mobile health (mHealth) interventions have been designed and implemented in LMIC settings to address this issue through health information dissemination via voice calls, apps, and short message services (SMS). Although the impact of mHealth programmes on postpartum family planning outcomes have been systematically reviewed, the contexts, conditions, and mechanisms underpinning programme engagement and their impact on outcomes remain unclear.

Dynamic modulation of the non-canonical NF-κB signaling pathway for HIV shock and kill.

HIV cure still remains an elusive target. The "Shock and Kill" strategy which aims to reactivate HIV from latently infected cells and subsequently kill them through virally induced apoptosis or immune mediated clearance, is the subject of widespread investigation. NF-κB is a ubiquitous transcription factor which serves as a point of confluence for a number of intracellular signaling pathways and is also a crucial regulator of HIV transcription.

Dataset from transcriptome profiling of resistant and susceptible cultivars in response to f.sp. race1 and TR4 challenges using Illumina NovaSeq.

In this investigation, the study focused on the RNAseq data generated in response to f.sp. (Foc) race1 (Cavendish infecting strain VCG 0124), targeting both resistant (cv.

Regulation of Thyroid Hormone Gatekeepers by Thyrotropin in Tanycytes.

Tanycytes are specialized glial cells within the mediobasal hypothalamus that have multiple functions, including hormone sensing and regulation of hypophysiotropic hormone secretion. There are ongoing discussions about the role of tanycytes in regulating the supply of hypothalamic thyroid hormones (THs) through the expression of TH transporters (, ) and deiodinases (, ). In this study, we investigated the potential feedback effect of thyrotropin (TSH) on the transcription of these gatekeeper genes on tanycytes.

A 1-D model to retrieve the vertical profiles of minor atmospheric constituents for cloud microphysical modelling: III. Disturbed weather situations.

A hybrid Monte-Carlo Gear solver developed earlier has been improvised to retrieve the vertical profiles of CH and NO during disturbed weather situations such as western disturbances, tropical cyclones, and heavy rainfall events over the megacities: Delhi, Kolkata, Chennai, and Mumbai. Due to rapid changes in the temperature during the passage of these systems over megacities, the percentage differences of CH and NO number concentrations were more compared to the Community Long-term Infrared Microwave Coupled Atmospheric Product System (CLIMCAPS). Therefore, the hybrid solver has been modified by improving maximum likelihood estimates of vertical temperature profiles.

Fate and transport modelling for evaluating antibiotic resistance in aquatic environments: Current knowledge and research priorities.

Antibiotics have revolutionised medicine in the last century and enabled the prevention of bacterial infections that were previously deemed untreatable. However, in parallel, bacteria have increasingly developed resistance to antibiotics through various mechanisms. When resistant bacteria find their way into terrestrial and aquatic environments, animal and human exposures increase, e.

A 1-D model to retrieve the vertical profiles of minor atmospheric constituents for cloud microphysical modeling: II. Simulation of diurnal cycle.

The accurate forecast of the diurnal cycle of the number concentration of trace gases is vital due to their influence on precipitation processes by controlling the number concentration of cloud condensation nuclei (CCN). 1-D hybrid Monte Carlo-Gear solver developed to retrieve vertical profiles of the number concentration of CCNs for microphysics modeling has been tested for representation of the diurnal cycle in the present paper. The retrieved profiles of CH and SO have been tested with the Copernicus Atmosphere Monitoring Service (CAMS) model at 3-hour time intervals for four megacities: Delhi, Kolkata, Chennai, and Mumbai for rainy and non-rainy days.

Phosphorus-Induced One-Step Synthesis of NiCoS Electrode Material for Efficient Hydrazine-Assisted Hydrogen Production.

Rational control of the reaction parameters is highly important for synthesizing active electrocatalysts. NiCoS is an excellent spinel-based electrocatalyst that is usually prepared through a two-step synthesis. Herein, a one-step hydrothermal route is reported to synthesize P-incorporated NiCoS.

Physical Examination of Potential Deceased Organ and Tissue Donors: An Overview of the European Landscape.

Physical examination (PE) of donors is essential to identify potential risks to the safety and efficacy of donated organs and tissues and is mandatory in the EU. However, no detailed guidance is available as to how PE should be performed. Health authorities (HA) and health professionals (HP) in member states of the European Committee on Organ Transplantation of the Council of Europe (CD-P-TO) and observer countries completed surveys relating to the regulatory requirements for PE and the professional practice of PE in their countries for organ and tissue donors.

Special Issue: Bioceramics, Bioglasses, and Gels for Tissue Engineering.

Undoubtedly, biomaterials such as bioceramics, bioactive glasses, and gels have attracted a wide range of research interest in the field of tissue engineering (TE), as they facilitate the essential support and environment for cells to grow, differentiate, and, specifically, regenerate new tissues [...

28 Validation of a closed system for dispensing serum eye drops.

Introduction: NHS Blood and Transplant Tissue and Eye Services (TES) offer a serum eyedrop (SE) service to patients suffering from severe ocular surface disease. SE are prepared from serum collected at blood donation sessions; the serum is diluted 1:1 with physiological saline. Formerly, 3ml aliquots of diluted serum were aliquoted into glass bottles in a Grade B clean room.

33 NHSBT tissue and eye services clinical support nurse team: advanced nursing practice.

NHS Blood and Transplant (NHSBT) Tissue and Eye Services (TES) save and improve the lives of thousands of patients every year.The Clinical Support Nurse Team (CSNT) within TES is an example of registered nurses working at an advanced level, making professionally autonomous decisions for which they are accountable.The concept of nurses working at this level began with a pilot study in 2012 under a robust governance system and change process within NHSBT.

Protection of haematopoietic progenitor cell donors: an updated overview of the European landscape.

Haematopoietic progenitor cell donation from bone marrow and mobilised peripheral blood obtained from related and unrelated donors is an established procedure. The donation process in general has proven to be safe, but in rare cases severe and even fatal events have been reported. The present study aimed at providing a description of the current situation of donor protection measures in Council of Europe member States.

A 1-D model to retrieve the vertical profiles of minor atmospheric constituents for cloud microphysical modeling: I. Formulation and validation.

Determining the number concentration of minor constituents in the atmosphere is very important as it determines the whole tropospheric chemistry process. These constituents may act as cloud condensation nuclei (CCN) and ice nuclei (IN), impacting heterogeneous nucleation inside the cloud. However, the estimations of the number concentration of CCN/IN in cloud microphysical parameters are associated with uncertainties.

adapts its investment into replication transmission according to the host environment.

The malaria parasite life cycle includes asexual replication in human blood, with a proportion of parasites differentiating to gametocytes required for transmission to mosquitoes. Commitment to differentiate into gametocytes, which is marked by activation of the parasite transcription factor , is known to be influenced by host factors but a comprehensive model remains uncertain. Here, we analyze data from 828 children in Kilifi, Kenya with severe, uncomplicated, and asymptomatic malaria infection over 18 years of falling malaria transmission.

Influence of Polyols on the In Vitro Biodegradation and Bioactivity of 58S Bioactive Sol-Gel Coatings on AZ31B Magnesium Alloys.

The mechanical qualities of AZ31B magnesium alloys make them a promising material for biodegradable metallic implants. However, rapid degradation limits the application of these alloys. In the present study, 58S bioactive glasses were synthesized using the sol-gel method and several polyols such as glycerol, ethylene glycol, and polyethylene glycol, were used to improve the sol stability and to control the degradation of AZ31B.

Can training over phone calls help improve outcomes for COVID-19 positive patients under home isolation? An analysis of the COVID-19 Care Companion Program in Punjab, India.

Background: Phone-supported recovery of COVID-19 patients in home isolation could be an effective way of addressing COVID-19 in contexts with limited resources. The COVID-19 Care Companion Program (CCP) is one such intervention, designed to support patients and their caregivers in remote, evidence-based management of COVID-19 symptoms.

Objective: To estimate the effect of providing phone-based training to COVID-19 patients and their caregivers on the likelihood of hospitalizations and mortality.

Met/HGFR triggers detrimental reactive microglia in TBI.

The complexity of signaling events and cellular responses unfolding in neuronal, glial, and immune cells upon traumatic brain injury (TBI) constitutes an obstacle in elucidating pathophysiological links and targets for intervention. We use array phosphoproteomics in a murine mild blunt TBI to reconstruct the temporal dynamics of tyrosine-kinase signaling in TBI and then scrutinize the large-scale effects of perturbation of Met/HGFR, VEGFR1, and Btk signaling by small molecules. We show Met/HGFR as a selective modifier of early microglial response and that Met/HGFR blockade prevents the induction of microglial inflammatory mediators, of reactive microglia morphology, and TBI-associated responses in neurons and vasculature.