Ewing's Sarcoma of the Orbit: A Case Report and Literature Review.

Ewing's sarcoma (ES) is a malignant small round cell neuroectodermal tumour primarily affecting children in the first and second decade of life. Since ES is difficult to control, early diagnosis is crucial, and the treatment requires a multimodality approach constituting chemotherapy, surgery and radiotherapy. Here, we present a case of ES of orbit in a 17-year-old female diagnosed in 2021.

A Diagnostic Quandary: Carboplatin-Paclitaxel-Induced Stevens-Johnson Syndrome in a Rare Case of Carcinosarcoma of the Esophagus and Review of the Literature.

Sarcomatoid carcinoma of the esophagus, a mixed tumor comprising both carcinomatous and sarcomatoid components and known as carcinosarcoma, is a rare malignancy. Clinically and radiologically, it presents like other esophageal cancers. Here we discuss the case of a 69-year-old male patient with sarcomatoid carcinoma of the esophagus who developed Stevens-Johnson syndrome (SJS) after chemotherapy with carboplatin and paclitaxel.

Early Clinical Outcomes in Patients of Carcinoma Cervix Treated With Volumetric Modulated Arc Therapy.

Objective Carcinoma cervix is one of the major cancers affecting Indian women. Concurrent chemo-radiotherapy is the standard of care in the treatment of carcinoma cervix. We aimed to study the outcomes and toxicity profile of volumetric modulated arc therapy (VMAT), an advanced modality of radiation delivery when used to treat patients with carcinoma cervix.

Inflammatory Myofibroblastic Tumor of the Testis in a Patient With Cecal Carcinoma.

Inflammatory myofibroblastic tumors (IMTs) are uncommon tumors that can be classified among fibroinflammatory disorders. IMTs are diagnosed after excluding all other entities, which can be considered differential diagnoses of IMTs. Microscopic examination of IMTs shows multiple myofibroblastic spindle cells, which are surrounded by inflammation.

Revealing the Roles of Part-of-Speech Taggers in Alzheimer Disease Detection: Scientific Discovery Using One-Intervention Causal Explanation.

Background: Recently, rich computational methods that use deep learning or machine learning have been developed using linguistic biomarkers for the diagnosis of early-stage Alzheimer disease (AD). Moreover, some qualitative and quantitative studies have indicated that certain part-of-speech (PoS) features or tags could be good indicators of AD. However, there has not been a systematic attempt to discover the underlying relationships between PoS features and AD.

Assessment of cosmesis and quality of life and their correlation using novel, validated methods in breast cancer patients who had undergone breast conservation therapy.

Purpose: To assess cosmesis [Breast Cancer Conservation Treatment. Cosmetic Results (BCCT.CORE) software] & QOL [EORTC QLQ (Quality of Life Questionnaire)-C30, BR23 questionnaires] using objective methods &to correlate effect of cosmesis on QOL (Quality of life) in breast cancer patients post BCT (Breast conservation therapy) using a cross-sectional observational study from a tertiary hospital.

Electronic transport in chaotic mesoscopic cavities: A Kwant and random matrix theory based exploration.

We investigate the spectral fluctuations and electronic transport properties of chaotic mesoscopic cavities using Kwant, an open source Python programming language based package. Discretized chaotic billiard systems are used to model these mesoscopic cavities. For the spectral fluctuations, we study the ratio of consecutive eigenvalue spacings, and for the transport properties, we focus on Landauer conductance and shot noise power.

An Analysis of Lung Cancer Screening Beliefs and Practice Patterns for Community Providers Compared to Academic Providers.

Despite guidelines recommending annual low-dose computed tomography (LDCT) screening for lung cancer, uptake remains low due to the perceived complexity of initiating and maintaining a clinical program-problems that likely magnify in underserved populations. We conducted a survey of community providers at Federally Qualified Health Centers (FQHCs) in Santa Clara County, California, to evaluate provider-related factors that affect adherence. We then compared these findings to academic providers' (APs) LDCT screening knowledge, behaviors, and attitudes at an academic referral center in the same county.

Hand Grasping Synergies As Biometrics.

Recently, the need for more secure identity verification systems has driven researchers to explore other sources of biometrics. This includes iris patterns, palm print, hand geometry, facial recognition, and movement patterns (hand motion, gait, and eye movements). Identity verification systems may benefit from the complexity of human movement that integrates multiple levels of control (neural, muscular, and kinematic).

A "safe and effective" protocol for management of post-thyroidectomy hypocalcemia.

Background: This study evaluates the outcomes of a protocol to manage hypocalcemia after thyroidectomy (TTX).

Methods: A review of prospectively collected data was performed in 130 patients who underwent TTX after the introduction of a specific protocol. These patients were compared with a control group of 195 patients who underwent TTX the year prior when routine calcium supplementation was utilized and no specific protocol was used.

A study on the performance and emission characteristics of esterified pinnai oil tested in VCR engine.

Biodiesel is a clean renewable fuel derived from vegetable oils and animal fats. It is biodegradable, oxygenated, non toxic and free from sulfur and aromatics. The biodiesel prepared from pinnai oil undergoes acid esterification followed by alkaline transesterification process.

Juvenile compensatory growth has negative consequences for reproduction in Trinidadian guppies (Poecilia reticulata).

Compensatory or 'catch-up' growth may be an adaptive mechanism that buffers the growth trajectory of young organisms from deviations caused by reduced food availability. Theory generally assumes that rapid juvenile compensatory growth impacts reproduction only through its positive effects on age and size at maturation, but potential reproductive costs to juvenile compensatory growth remain virtually unexplored. We used a food manipulation experiment to examine the reproductive consequences of compensatory growth in Trinidadian guppies (Poecilia reticulata).

Caco-2 cell lines in drug discovery- an updated perspective.

Cell lines are the invitro models used for the drug permeability studies in the preclinical and clinical phases of the drug discovery. Cell line models are simple and quick to use and avoids the usage of animal models for pharmacological and toxicological studies and hence cost effective, produce reliable and reproducible results for understanding and evaluating the permeability characteristics of the potential lead drug candidates. Different cell line models used in the drug permeability studies, their characteristics has been summarized emphasizing on CACO-2.

Ofloxacin targeting to lungs by way of microspheres.

The efficacy of drug candidates is frequently limited by their inability to reach the target site of action, especially when they are administered through conventional dosage forms or drug delivery systems. Targeted drug delivery systems have increased the amount of drug reaching the site and simultaneously decrease the amount being distributed to other parts of the body. Microspheres have emerged as a remedial measure to improve site-specific drug delivery to a considerable extent.

Right-left asymmetry in tonic pain perception and its modification by simultaneous contralateral noxious stimulation.

Administration of the cold pressor test (I test) in normal healthy subjects revealed lateralization of pain perception with the right hand showing higher threshold and tolerance, as well as lower pain scores on Graphic Rating Scale, PPI and MPQ. To find out whether this lateralization persists, the cold pressor test was given while the contralateral hand was simultaneously exposed to non-noxious stimulus (II test) or noxious stimulus (III test). Reversal of laterality to the left hand was observed in the III test in 40% of the subjects for pain threshold.