The effect of early coasting on blastocyst development and outcome following blastocyst transfer in IVF/ICSI programme.

Objective: Coasting is a well-known strategy to decrease severity of Ovarian Hyperstimulation Syndrome (OHSS). The purpose of this study is to assess the effect of Coasting on blastocyst development and subsequent clinical outcome following exclusive blastocyst transfer.

Methods: We conducted an observational cohort study of patients having blastocyst transfer following IVF/ICSI treatment.

Review of the safety, efficacy and patient acceptability of the levonorgestrel-releasing intrauterine system.

The levonorgestrel-containing intrauterine system is an extremely effective, reversible and safe form of long-term yet reversible birth control. In view of its efficacy, it is a safer alternative to permanent contraceptive methods such as sterilization. It is especially useful in situations where use of estrogen-containing contraceptives is contraindicated.

Review of the evidence base of strategies to prevent ovarian hyperstimulation syndrome.

The English-language literature was reviewed to examine the evidence base for strategies that have been used to prevent ovarian hyperstimulation syndrome (OHSS). Prediction of OHSS by pretreatment patient characteristics and ovarian response parameters is unreliable, with a significant number of OHSS cases occurring in patients not thought to be high risk, while the majority of 'high-risk' cycles do not result in OHSS. Alternatives to ovarian stimulation should always be considered, depending on the clinical situation.