Publications by authors named "Chandra Balachandran"

Purpose: The purpose of this study was to examine the effect of intra-operative live refraction stability as a surrogate marker of ocular surface hydration on intra-operative aberrometry (IA) results and to quantify the minimum duration of stable refraction needed to achieve accurate intraocular lens (IOL) selection.

Methods: In this nonrandomized consecutive retrospective chart review, 18,000 data points from 45 live refraction runs of 15 patients were digitized and analyzed. An objective automated moving average method of frames lengths of 88 ms, 110 ms, and 132 ms with less than 0.

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Purpose: To evaluate the efficacy of anterior segment optical coherence tomography (OCT), Scheimpflug imaging, and slit-lamp biomicroscopy in the early detection of a (partial) graft detachment after Descemet membrane endothelial keratoplasty (DMEK).

Methods: Anterior segment OCT, Scheimpflug imaging, and slit-lamp biomicroscopy were performed in 120 eyes of 110 patients after DMEK.

Results: Seventy-eight eyes showed a normal corneal clearance, and the attached Descemet grafts could not be identified with any of the imaging techniques.

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Purpose: To determine the refractive change and stability of the transplanted cornea after Descemet membrane endothelial keratoplasty (DMEK) through a 3.0 mm clear corneal incision.

Setting: Tertiary referral center.

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Purpose: To describe spontaneous recovery of corneal transparency in 2 cases with nearly complete graft detachment after Descemet membrane endothelial keratoplasty (DMEK).

Design: Case series.

Methods: In 2 patients with Fuchs endothelial dystrophy, DMEK was performed.

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A 6-month-old boy presented with a congenital eye movement disorder consistent with congenital fibrosis of the extraocular muscles type 1 (CFEOM1). Mutational analysis confirmed the most common mutation in the CFEOM1 gene KIF21A. In addition to the typical findings in CFEOM1, distinctive conjunctival changes and small bilateral optic disc colobomata were also noted.

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Purpose: To describe an uncommon case of malignant optic glioma and the challenges in its diagnosis.

Methods: Case report with funduscopic, magnetic resonance imaging (MRI), and automated field test correlations.

Patient: A 60-year-old man presented with a 1-week history of left optic disk swelling and optic neuropathy that was initially diagnosed as nonarteritic anterior ischemic optic neuropathy (NA-AION).

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We describe a needle insertion technique for graft insertion in Descemet-stripping (automated) endothelial keratoplasty (DSEK/DSAEK). A folded donor posterior corneal disk is inserted through a 5.0 mm scleral tunnel incision over a plastic glide using a 30-gauge needle.

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Objective: To evaluate visual rehabilitation after Descemet membrane endothelial keratoplasty (DMEK) in the management of corneal endothelial disorders.

Methods: In this prospective, nonrandomized, clinical study, DMEK was performed in a first group of 35 consecutive patients with either Fuchs endothelial dystrophy or bullous keratopathy. The Descemet membrane was stripped from the recipient posterior stroma with the anterior chamber completely filled with air.

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Purpose: To report a case of Mycobacterium hemophilum of the eye.

Methods: Case report with pathologic correlation. A 55-year-old Malaysian man with a 3-year history of graft-versus-host disease presented with dry eye and keratopathy.

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The purpose of this study was to investigate the influence of pupil diameter on the amplitude and latency of multifocal visual evoked potentials (mfVEP). The multifocal objective perimeter (Accumap; Objectivision) was used to stimulate the visual field at 56 sites extending to 32 degrees using a pseudo-random pattern stimulus. The mfVEP were recorded using bipolar occipital electrodes, 7 min/eye.

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In this study we examined the effects of varying stimulus check size on multifocal visual evoked potential (VEP). We also evaluated the currently used cortical scaling of stimulus segments. The ObjectiVision multifocal objective perimeter stimulates the eye with random check patterns at 56 cortically scaled segments within the visual field extending to a radius of 26 degrees.

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A 53-year-old Caucasian woman with long-standing, well controlled, severe rheumatoid arthritis, treated with methotrexate, salazopyrin, naprosyn, prednisone and plaquenil, presented with progressive visual loss in each eye. She had a past history of non-necrotizing anterior scleritis that was treated with increased doses of prednisone. She developed left then right central scotomas, reduced vision and optic atrophy.

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