Publications by authors named "Chandeshwar Sharma"
Article Synopsis
- Breast cancer patients resistant to neoadjuvant chemotherapy (NeoCT) have a poor prognosis, creating a need for effective in vivo models to test new treatments.
- The study established 13 patient-derived breast cancer xenografts (BCXs) from 48 tumors, showing higher engraftment rates in triple-negative breast cancer (TNBC) and in patients who had poor responses to NeoCT.
- Results indicate that BCXs maintain genomic profiles and are linked to worse outcomes, suggesting they can serve as valuable models for researching personalized treatments in aggressive breast cancers.
The mammalian target of rapamycin (mTOR) is a central controller of cell growth and is currently being investigated as a potential target in breast cancer therapy. The essential amino acid leucine has been proposed to regulate mTOR signaling. The objective of this study was to determine whether leucine restriction would inhibit mTOR signaling in breast cancer cells.
View Article and Find Full Text PDFRibosomal protein S6 kinase 1 (S6K1), a critical mediator of cell growth, is overexpressed in breast cancer and is associated with poor prognosis. S6K1 has two known isoforms, p85(S6K1) and p70(S6K1). p85(S6K1) is characterized by 23 additional amino acids in the N-terminus of p70(S6K1).
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