Publications by authors named "Chander S"

Background And Aims: To investigate gender, racial, ethnic, and regional disparities in first and senior authorship positions in gastroenterology/hepatology-related randomised controlled trials (RCT).

Method: Retrospective bibliometric analysis of PubMed-indexed RCTs published between January 2000 to December 2022 in leading journals with an impact factor of at least five.

Results: 943 RCTs met our inclusion criteria, providing a participant pool of 301 female (15.

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India is a treasure trove of biological diversity with its plant genetic resources playing a crucial role in the crop improvement serving as the foundation for the country's sustainable food and nutritional security. India's in vitro genebank (IVG) is part of the National Genebank at the Indian Council of Agricultural Research-National Bureau of Plant Genetic Resources (ICAR-NBPGR). The IVG houses distinctive multi-crop repository that utilizes several tissue culture techniques for short- to medium-term storage in in vitro active genebank (IVAG) and cryoconservation approaches for long-term storage in in vitro base genebank (IVBG).

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The availability of an effective vaccine does not equate to its use; its effectiveness primarily depends on vaccine acceptance by the targeted population. Despite the rapid development and widespread access to the COVID-19 vaccine, herd immunity is yet to be achieved, with vaccine hesitancy as a major barrier. This study sought to systematically assess the beliefs, attitudes, and acceptance towards COVID-19 vaccines, including factors contributing to vaccination hesitancy in the Eastern and Western Hemispheres.

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Article Synopsis
  • Phytophthora infestans is a serious pathogen causing late blight disease in potatoes, impacting them throughout their growth stages and spreading quickly.
  • Field experiments in the 2020-21 and 2021-22 winter seasons tested the effectiveness of novel fungicides, showing that certain treatments resulted in the lowest disease incidence and highest tuber yields.
  • The study found that late blight is positively correlated with temperature, humidity, and sunlight, and the use of specific fungicides significantly reduced disease severity and increased profitability compared to untreated controls.
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Leveraging hyperspectral data across various domains yields substantial benefits, yet managing many spectral bands and identifying the essential ones poses a formidable challenge. This study identifies the most relevant bands within a hyperspectral data cube for turbidity prediction in inland water. Nine machine learning regressors Cat Boost, Decision Trees, Extra Trees, Gradient Boost, Light Gradient Boost (LightGBM), Recursive Feature Elimination (RFE), Random Forest, Support Vector Regressor (SVR), and Xtreme Gradient Boost (XGBoost) have been used to compute the feature importance of the hyperspectral bands for predicting turbidity.

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Cryopreservation serves as an invaluable technique for safeguarding the genetic diversity of plants and various organisms, while also facilitating fundamental biological research. Despite notable advancements in this field, the cryopreservation of certain cell types and tissues remains challenging, particularly those that exhibit sensitivity to low temperatures. Two-celled pollen is a promising model system for the study of cryopreservation.

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  • Patients with advanced and difficult-to-treat tumors often experience significant symptoms and frailty due to the tumors' mass effects, especially with types like sarcomas that are resistant to traditional treatments.
  • A new technique called Partially Ablative Body Radiotherapy (PABR) uses a concentrated radiation dose to target the tumor's center while providing a lower, safer dose to the surrounding tissue, aiming to relieve symptoms and reduce tumor size.
  • The protocol described in the paper involves delivering 20Gy in 5 fractions to target areas, with higher doses of up to 65-70Gy to specific regions, and it shows promise for improving palliative care in patients with complex tumor presentations.
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  • The study examines the effects of low vs. high vancomycin trough levels on clinical outcomes in adults with sepsis or gram-positive infections, moving away from the previously recommended dosage guidelines.
  • A systematic review and meta-analysis of 14 studies involving over 5,200 patients showed no significant links between vancomycin levels and various clinical outcomes like microbial clearance and ICU stay.
  • However, lower trough levels appeared to trend towards reduced treatment failure and were significantly associated with lower all-cause mortality rates.
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  • The systematic review and meta-analysis aimed to evaluate the effectiveness, safety, and tolerability of using urea to treat hyponatremia caused by SIADH, addressing previously raised concerns in the medical community.
  • The study analyzed existing observational research from multiple databases, focusing on patients with SIADH-related low sodium levels and including trials that measured outcomes like serum sodium concentration and any adverse effects from urea administration.
  • Results showed that urea treatment led to a significant improvement in serum sodium levels, particularly in more severe cases of hyponatremia, indicating it may be an effective treatment option despite some variability in outcomes.
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Purpose: Brachytherapy as monotherapy is a recommended treatment option for men with low to intermediate risk prostate cancer. Local recurrence is difficult to identify. This study investigated PSMA PET/CT for recurrence after brachytherapy, as well as their subsequent management when recurrence occurred only within the prostate.

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Breast cancer with increased risk in women is identified with Breast Magnetic Resonance Imaging (Breast MRI) and this helps in evaluating treatment therapies. Breast MRI is time time-consuming process that involves the assessment of current imaging. This research work depends on the detection of breast cancer at the earlier stages.

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Introduction: Obesity is characterized by chronic low-grade inflammation. This study presents an updated systematic review and meta-analysis on the effect of caloric restriction (CR) and intermittent fasting (IF) on plasma inflammatory biomarkers (C-reactive protein [CRP], tumor necrosis factor [TNF]-alpha, and interleukin [IL]-6) in individuals with obesity/overweight compared with unrestricted or ad libitum feeding.

Methods: PubMed, Web of Science, and SCOPUS databases were searched for randomized controlled trials (RCTs) reporting inflammatory biomarkers after at least 8 weeks of intervention.

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Unlabelled: Severe incidence of spp. was observed in the three solanaceous vegetables viz. tomato, potato and brinjal grown in National Capital Region of Delhi and Haryana.

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Integrated pest management (IPM) is a comprehensive approach to managing diseases, focusing on combining various strategies to reduce pathogen populations effectively and in an environmentally conscious way. We investigated the effects of IPM on beneficial microbial populations and its relationship with pathogen populations in both direct-seeded rice (DSR) and transplanted rice (TR) systems. This study demonstrates that IPM practices have significantly higher populations of beneficial microbes, such as and , and lower level of the pathogen compared to non-IPM (farmer practices).

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Purpose: Lattice radiation therapy (LRT) alternates regions of high and low doses inside the tumour. Whilst this technique reported positive results in tumour size reduction, optimal lattice parameters are still unknown. We introduce an automated LRT planning method personalised to tumour shape and designed to allow investigation of lattice geometry.

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  • A 26-year-old woman who had high-dose radiation for rectal cancer was studied for her ability to conceive using her own uterus, which had been affected by the treatment.
  • After assessing her uterus and performing ovarian tissue grafts, she underwent several IVF cycles, resulting in one successful live birth.
  • This case suggests that despite previous radiation exposure, a successful pregnancy can occur with careful monitoring and interventions, highlighting the need for further research on reproductive outcomes in similar circumstances.
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Background: Catheter ablation and antiarrhythmic drug therapy are utilized for rhythm control in atrial fibrillation (AF), but their comparative effectiveness, especially with contemporary treatment modalities, remains undefined. We conducted a systematic review and meta-analysis contrasting current ablation techniques against antiarrhythmic medications for AF.

Methods: We searched PubMed, SCOPUS, Cochrane CENTRAL, and Web of Science until November 2023 for randomized trials comparing AF catheter ablation with antiarrhythmics, against antiarrhythmic drug therapy alone, reporting outcomes for > 6 months.

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  • A study was conducted to evaluate the effectiveness and safety of various vasopressors, like epinephrine and vasopressin, in patients who experienced cardiac arrest, focusing on clinical and mortality outcomes.
  • The analysis included 26 studies and found that epinephrine significantly improved survival rates to hospital discharge and the return of spontaneous circulation compared to a placebo, but did not show advantages in other outcomes like short-term survival or neurological function.
  • Combinations of vasopressors did not outperform epinephrine alone, though there was a slight improvement in survival to hospital admission with combined therapies.
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Powered prosthetic hands capable of executing various grasp patterns are highly sought-after solutions for upper limb amputees. A crucial requirement for such prosthetic hands is the accurate identification of the intended grasp pattern and subsequent activation of the prosthetic digits accordingly. Vision-based grasp classification techniques offer improved coordination between amputees and prosthetic hands without physical contact.

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Introduction: Acute pancreatitis poses a significant health risk due to the potential for pancreatic necrosis and multi-organ failure. Fluid resuscitation has demonstrated positive effects; however, consensus on the ideal intravenous fluid type and infusion rate for optimal patient outcomes remains elusive.

Methods: A comprehensive literature search was conducted using PubMed, Embase, the Cochrane Library, Scopus, and Google Scholar for studies published between 2005 and January 2023.

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Primary aortic angiosarcomas (PAA) are rare angiosarcomas, frequently diagnosed in advanced stages due to initial misdiagnosis. This case describes a 66-year-old woman, initially presenting with a distal thoracic aorta thrombus and symptomatic bilateral popliteal emboli. Despite initial management and therapeutic anticoagulation, she experienced progressive lower limb claudication and 12 months following initial presentation she re-presented with an obstructing distal thoracic aorta mass and metastatic disease.

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Background: In recent years, innovation in healthcare technology has significantly improved the efficiency of the healthcare system. Advancements have led to better patient care and more cost-effective services. The electronic medical record (EMR) system, in particular, has enhanced interoperability and collaboration across healthcare departments by facilitating the exchange and utilization of patient data.

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This research work aimed to isolate and culture the bacterium for biogenic fabrication of zinc oxide nanoparticles, specifically ZnO and ZnO-ME nanoparticles (nanoparticles fabricated from bacterial extracts only - ZnO, and from bacterial cell mass including extract - ZnO-ME). SEM investigation revealed the spherical-shaped NPs with 22.33 and 39 nm in size for ZnO and ZnO-ME, respectively.

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