Reproduction in male rats is vulnerable to treatment with the flavonoid-rich seed extracts of Vitex negundo.

A partially purified flavonoid-rich extract was prepared from the seed of Vitex negundo. The effect of this extract on the reproductive system of male rats was investigated at four different concentrations. All the major accessory sex organs shed weight when the preparation was administered at doses of >or=15 mg/rat/day after 15 days of treatment.