Possible sarcopenia, sarcopenic obesity phenotypes and their association with diabetes: Evidence from LASI wave-1 (2017-18).

Aims: To assess the prevalence of possible sarcopenia and sarcopenic obesity phenotypes and investigate their association with self-reported diabetes among community-dwelling individuals aged 45 or above.

Methods: Utilizing data from 62,899 individuals in LASI wave-1 (2017-18), the assessment of possible sarcopenia was done on two critical parameters: muscle (handgrip) strength and physical performance (gait speed), following the 2019 guidelines from the Asian working group on sarcopenia (AWGS). BMI, WC, WHR, and WHtR defined sarcopenic obesity phenotypes.

Microbes mediated alleviation of chromium (Cr VI) stress for improved phytoextraction in fodder maize ( L.) cultivar.

This study investigates the potential of chromium (VI) resistant bacterial isolates to alleviate heavy metal stress in fodder maize plants and enhance phytoremediation. Twenty-one bacterial strains were isolated from contaminated water, with five strains; (BHR1) (BHR2), (BHR4), (BHR5) and (BHR6) selected based on their significant plant-growth promoting (PGP) traits and heavy metal tolerance. Under chromium (Cr VI) stress, the BHR1 strain significantly improved seed germination, seedling length and vigor index of fodder maize variety (J 1007) especially at 150 mg/L Cr (VI), where these parameters increased by 3.

Understanding LC/MS-Based Metabolomics: A Detailed Reference for Natural Product Analysis.

Liquid chromatography, when used in conjunction with mass spectrometry (LC/MS), is a powerful tool for conducting accurate and reproducible investigations of numerous metabolites in natural products (NPs). LC/MS has gained prominence in metabolomic research due to its high throughput, the availability of multiple ionization techniques and its ability to provide comprehensive metabolite coverage. This unique method can significantly influence various scientific domains.

Cryobiological aspects of upscaling cryopreservation for encapsulated liver cell therapies.

For the efficient delivery of a cell therapy a treatment must be provided rapidly, at clinical scale, contain a sufficient active cellular component (biomass), and adhere to a multitude of regulatory requirements. Cryopreservation permits many of these demands to be met more readily. Here we present the cryopreservation and recovery of large volume (2.

Global Challenges After a Global Challenge: Lessons Learned from the COVID-19 Pandemic.

Coronavirus disease 2019 (COVID-19) has affected not only individual lives but also the world and global systems, both natural and human-made. Besides millions of deaths and environmental challenges, the rapid spread of the infection and its very high socioeconomic impact have affected healthcare, economic status and wealth, and mental health across the globe. To better appreciate the pandemic's influence, multidisciplinary and interdisciplinary approaches are needed.

Association of handgrip strength with various anthropometric variables and musculoskeletal disorders among the Jat farmers of Haryana.

The handgrip strength test is mostly used as a proxy test of overall muscle strength and is associated with increased mortality and physical disability. Handgrip strength is affected by various factors, such as age, Height, weight, and BMI. This study aimed to investigate the association between handgrip strength, anthropometric variables, and musculoskeletal disorders among Jat farmers in Haryana.

An Indian classical dance form, Kathak in maintaining handgrip strength symmetry and reducing the risk of hypertension.

Background: The present paper aimed to study handgrip strength (HGS) asymmetry and its association with hypertension in a sample of Kathak dancers and non-dancers of North India.

Methods: Data on HGS and blood pressure were collected from 206 Kathak dancers and 235 age-matched controls, using standardized protocols. Pearson correlation coefficients assessed the association between HGS and hypertension, and binary logistic regression identified the risk of developing hypertension.

Exploring the combined effect of heavy metals on accumulation efficiency of raised on lead and cadmium contaminated soils.

The present study illustrated that can accumulate high level of Pb and Cd in different plant parts, with maximum accumulation in roots followed by stem and leaves in the order Cd > Pb > Cd + Pb. The phytoremediation evaluation factors such as bioconcentration factor (BCF) and translocation factor (TF) was higher for Cd over Pb in all plant parts, further the BCF for both Pb and Cd was maximum in root (BCF > 1) followed by stem and leaves. Higher accumulation of Cd over the Pb was observed inside the plant tissues due to Cd mimics with other elements and gets transported through respective transporters.

Quality of Life and Its Biopsychosocial Determinants: A Study Among the Yadav Community From Delhi, India.

Introduction The COVID-19 pandemic has not only affected the physical and mental health of people but has also had a detrimental impact on their quality of life (QoL). Therefore, ways to improve the QoL must be promoted for the overall well-being of individuals and society. The present study aims to assess the status of QoL and understand its association with physical and mental variables among the Yadav community of Delhi.

A genetic screen to uncover mechanisms underlying lipid transfer protein function at membrane contact sites.

Lipid transfer proteins mediate the transfer of lipids between organelle membranes, and the loss of function of these proteins has been linked to neurodegeneration. However, the mechanism by which loss of lipid transfer activity leads to neurodegeneration is not understood. In photoreceptors, depletion of retinal degeneration B (RDGB), a phosphatidylinositol transfer protein, leads to defective phototransduction and retinal degeneration, but the mechanism by which loss of this activity leads to retinal degeneration is not understood.

Sustained release of Zn from zinc sulfide nanoparticles (ZnS NPs) amplified the bioaccessibility of Zn in soil: Adsorption dynamics and dissolution kinetics.

Controlled-release micronutrient supplementation to provide better bioavailable zinc (Zn) under alkaline soil conditions is a concept of commercial pertinence for sustainable agriculture. High pH stable nano-scaled ZnS is the material under study in the present investigation where the adsorption dynamics and dissolution kinetics of sono-chemically synthesized zinc sulfide nanoparticles (ZnS NPs) were evaluated in comparison to ZnSO in Lufa 2.2 soil for supplementation of Zn.

Unveiling the epigenetic landscape of plants using flow cytometry approach.

Plants are sessile creatures that have to adapt constantly changing environmental circumstances. Plants are subjected to a range of abiotic stressors as a result of unpredictable climate change. Understanding how stress-responsive genes are regulated can help us better understand how plants can adapt to changing environmental conditions.

Unravelling the role of long non-coding RNAs in modulating the Hedgehog pathway in cancer.

Cancer is a multifactorial pathological condition characterized by uncontrolled cellular proliferation, genomic instability, and evasion of regulatory mechanisms. It arises from the accumulation of genetic mutations confer selective growth advantages, leading to malignant transformation and tumor formation. The intricate interplay between LncRNAs and the Hedgehog pathway has emerged as a captivating frontier in cancer research.

Global Emergence of SARS-CoV2 Infection and Scientific Interventions to Contain its Spread.

The global pandemic caused by COVID-19 posed a significant challenge to public health, necessitating rapid scientific interventions to tackle the spread of infection. The review discusses the key areas of research on COVID-19 including viral genomics, epidemiology, pathogenesis, diagnostics, and therapeutics. The genome sequencing of the virus facilitated the tracking of its evolution, transmission dynamics, and identification of variants.

MicroRNA-21's role in PTEN suppression and PI3K/AKT activation: Implications for cancer biology.

MicroRNA-21 (miR-21) was recognized as a key figure in the intricate web of tumor biology, with a prominent role in regulating the PTEN tumor suppressor gene and the PI3K/AKT cascade. This review elucidates the multifaceted interactions between miR-21, PTEN, and the PI3K/AKT signaling, shedding light on their profound implications in cancer initiation, progression, and therapeutic strategies. The core of this review delves into the mechanical intricacies of miR-21-mediated PTEN suppression and its consequent impact on PI3K/AKT pathway activation.

Effect of stroke plane inclination on the hovering aerodynamic performance of tandem flapping foils.

The four-winged form of dragonfly and damselfly allows them to fly with great agility and endurance, which are accomplished by independently controlling the kinematics of each wing. In this study, we performed numerical simulations of two tandem airfoils oscillating along an inclined stroke plane atRe=157. We investigated the effects of the stroke plane angle (β)of forefoil and hindfoil on the aerodynamic performance of dragonflies (or damselflies) hovering flight.

Flow cytometry: Aspects and application in plant and biological science.

Flow cytometry is a potent method that enables the quick and concurrent investigation of several characteristics of single cells in solution. Photodiodes or photomultiplier tubes are employed to detect the dispersed and fluorescent light signals that are produced by the laser beam as it passes through the cells. Photodetectors transform the light signals produced by the laser into electrical impulses.

Reflecting on changes in the drinking and irrigation water quality of rivers Beas, Satluj and confluence waters.

Prevention and control of water pollution for maintaining and restoring the wholesomeness of rivers are unavoidable. The current water quality approach of designated best use has some limitations such as it is non-integrative and inflexible with regard to the consideration of variables and does not provide a separate rating scale for a given designated use. We thus used water quality index approach proposed by the Canadian Council of Ministers of the Environment (CCME WQI) to evaluate and develop a separate rating system for drinking and irrigation purposes of rivers Beas, Satluj and their confluence water of the Indian Punjab using information collected over 4 years (2016 to 2019).

Emerging roles of SnoRNAs in the pathogenesis and treatment of autoimmune disorders.

SnoRNAs (small non-coding RNAs) have recently gained prominence in autoimmune diseases, revealing their crucial role in modulating the immune response and contributing to disease pathogenesis. Initially known for their involvement in ribosomal RNA processing and modification, molecular biology and genomics advancements have uncovered their broader impact on cellular function, especially in autoimmune disorders. Autoimmune diseases represent conditions characterized by the immune system's erroneous attacks on self-tissues, encompassing disorders like systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis.

A recent update on development, synthesis methods, properties and application of natural products derived carbon dots.

Natural resources are practically infinitely abundant in nature, which stimulates scientists to create new materials with inventive uses and minimal environmental impact. Due to the various benefits of natural carbon dots (NCDs) from them has received a lot of attention recently. Natural products-derived carbon dots have recently emerged as a highly promising class of nanomaterials, showcasing exceptional properties and eco-friendly nature, which make them appealing for diverse applications in various fields such as biomedical, environmental sensing and monitoring, energy storage and conversion, optoelectronics and photonics, agriculture, quantum computing, nanomedicine and cancer therapy.

Molecular mechanism of induced apoptosis in cultured human intestinal epithelial cells.

Enteroaggregative (EAEC) is an evolving etiological agent of acute and persistent diarrhoea worldwide. The previous study from our laboratory has reported the apoptosis-inducing activity of EAEC in human small intestinal and colonic epithelial cell lines. In the present investigation, we have explored the underlying mechanism of EAEC-induced apoptosis in human intestinal epithelial cell lines.