Publications by authors named "Chandan Pavuluri"
Background: Asthma and chronic obstructive pulmonary disease (COPD) have distinct and overlapping genetic and clinical features.
Objective: We sought to test the hypothesis that polygenic risk scores (PRSs) for asthma (PRS) and spirometry (FEV and FEV/forced vital capacity; PRS) would demonstrate differential associations with asthma, COPD, and asthma-COPD overlap (ACO).
Methods: We developed and tested 2 asthma PRSs and applied the higher performing PRS and a previously published PRS to research (Genetic Epidemiology of COPD study and Childhood Asthma Management Program, with spirometry) and electronic health record-based (Mass General Brigham Biobank and Genetic Epidemiology Research on Adult Health and Aging [GERA]) studies.
Article Synopsis
- - The study aimed to identify different subpopulations of patients seeking care post-COVID-19 based on their symptoms and resource utilization to improve personalized care and access to specialized services.
- - Researchers analyzed data from 1,285 COVID-19 patients in Boston, uncovering three distinct clusters, with varying demographics and experiences related to ICU admissions and symptom reporting.
- - Findings show that patients differ significantly in how they utilize recovery resources, indicating the need for tailored strategies to address the specific needs of these diverse subpopulations for better recovery outcomes.
Article Synopsis
- A major study involving 580,869 participants identified 1,020 genetic signals linked to lung function impairment, which is crucial in understanding chronic obstructive pulmonary disease (COPD) and predicting mortality.
- * The research found 559 genes related to lung function that were connected to 29 different biological pathways and demonstrated variations across ancestry, age, and smoking habits.
- * Findings suggest potential new targets for therapy by highlighting specific genetic variants and proteins, ultimately contributing to better understanding and treatment of COPD.