Depression Related Pathophysiologies Relevant in Heart Disease: Insights into the Mechanism Based on Pharmacological Treatments.

Depressive symptoms are highly prevalent in patients with cardiac diseases. Co-morbid Depression in cardiac patients causes a significant reduction in health-related quality of life for the patients and inflicts an economic burden on the society. Two types of mechanisms that may explain the link between depression and cardiac diseases are the psychosocial and physiopathological mechanisms.

Charge Transport Properties of Hybrid Nanocomposites Based on Colloidal PbSe Quantum Dots in Poly(2-methoxy,5-(2'-ethylhexyloxy)-P-Phenylenevinylene (MEH-PPV) Matrix.

The synthesis of PbSe nanoparticles were carried out by colloidal route using lead acetate as starting material with Oleic acid/TOP as capping agents at the optimized growth temperature. The phase and surface analysis of oleic acid/TOP capped PbSe nanocrystallites were studied in detail in this article. Current-voltage characteristics of pristine and lead selenide quantum dots (PbSe QDs) incorporated in poly(2-methoxy,5-(2'-ethylhexyloxy)-p-phenylenevinylene (MEH-PPV) thin films have been studied at different temperatures (306-125 K) in hole only device configuration, i.

Factors Leading To Meconium Aspiration Syndrome in Term- and Post-term Neonates.

Background Meconium aspiration syndrome (MAS) is considered a major cause of respiratory morbidity. It is a common issue encountered in the delivery room and newborn nursery. There is a need to identify the factors that lead to MAS to develop strategies to screen such patients at an early stage to decrease the mortality and morbidity.

Eosin-Y-Catalyzed Photoredox C-S Bond Formation: Easy Access to Thioethers.

An operationally simple Eosin Y catalyzed sulfenylation of hydrazones has been realized to afford a range of thioethers under visible light. The methodology provides high yields of thioethers under ambient conditions employing readily available and inexpensive starting materials. The reaction has broad substrate scope and is compatible with various functional groups.

Extracellular Vesicles as Drug Delivery Vehicles to the Central Nervous System.

Effective drug delivery to the CNS to achieve the desired therapeutic response is a significant challenge in the field of drug delivery. In central nervous system (CNS), blood brain barrier (BBB) restricts the desired therapeutic responses due to inefficient targeting, release kinetics, and failure to reach therapeutic concentrations in the brain. Therefore, most potentially beneficial diagnostic and therapeutic agents are not able to reach to the brain upon systemic administration.

Expression of short hairpin RNA (shRNA) targeting AC2 gene of (MYMIV) reduces the viral titre in soybean.

(MYMIV) belonging to the family and the genus is a severe pathogen of tropical legumes including soybean. The absence of genetically mapped loci conferring resistance together with the genetic diversity of begomoviruses infecting soybean warrants the utilization of RNA interference (RNAi) technology to develop virus resistance. However, viral suppressors of RNAi (VSRs) reduce the effectiveness of RNA silencing.

A Microporous Co-MOF for Highly Selective CO Sorption in High Loadings Involving Aryl C-H···O═C═O Interactions: Combined Simulation and Breakthrough Studies.

In the context of porous crystalline materials toward CO separation and capture, a new 2-fold interpenetrated 3D microporous Co-MOF, IITKGP-11 (IITKGP denotes Indian Institute of Technology Kharagpur), has been synthesized consisting of a 1D channel of ∼3.6 × 5.0 Å along the [101] direction with a cavity volume of 35.

Socioeconomic determinants of community knowledge and practice in relation to malaria in high- and low-transmission areas of central India.

This study was undertaken with an aim of exploring community knowledge and treatment practices related to malaria and their determinants in high- and low-transmission areas of central India. A community-based cross-sectional study was carried out between August 2015 and January 2016 in two high- and two low-malaria-endemic districts of central India. A total of 1470 respondents were interviewed using a pre-tested structured interview schedule.

Poly (ADP) Ribose Glycohydrolase Can Be Effectively Targeted in Pancreatic Cancer.

Patients with metastatic pancreatic ductal adenocarcinoma (PDAC) have an average survival of less than 1 year, underscoring the importance of evaluating novel targets with matched targeted agents. We recently identified that poly (ADP) ribose glycohydrolase (PARG) is a strong candidate target due to its dependence on the pro-oncogenic mRNA stability factor HuR (). Here, we evaluated PARG as a target in PDAC models using both genetic silencing of PARG and established small-molecule PARG inhibitors (PARGi), PDDX-01/04.

Pleiotropic Impact of DNA-PK in Cancer and Implications for Therapeutic Strategies.

Purpose: DNA-dependent protein kinase catalytic subunit (DNA-PK) is a pleiotropic kinase involved in DNA repair and transcriptional regulation. DNA-PK is deregulated in selected cancer types and is strongly associated with poor outcome. The underlying mechanisms by which DNA-PK promotes aggressive tumor phenotypes are not well understood.

Field evaluation of zero vector durable lining to assess its efficacy against malaria vectors and malaria transmission in tribal areas of the Balaghat district of central India.

Background: Indoor residual spray (IRS) and long-lasting insecticidal nets are the two principal intervention methods of vector control. Zero vector durable lining (ZVDL), a relatively new vector control method, was evaluated to assess its efficacy against malaria vectors in hard to reach areas in the Balaghat district, where malaria transmission is perennial.

Methods: ZVDL was installed in six experimental villages during November-December 2012.

Central mucoepidermoid carcinoma: Case report with review of literature.

Occurrence of central mucoepidermoid carcinoma within the jaw bones from aberrant salivary tissues is extremely rare and accounts for 2%-4% of all central mucoepidermoid carcinoma. Mandible is more commonly affected than maxilla in a ratio of 2:1. The origin of mucoepidermoid carcinoma is controversial and questionable.

Downregulation of an Evolutionary Young miR-1290 in an iPSC-Derived Neural Stem Cell Model of Autism Spectrum Disorder.

The identification of several evolutionary young miRNAs, which arose in primates, raised several possibilities for the role of such miRNAs in human-specific disease processes. We previously have identified an evolutionary young miRNA, miR-1290, to be essential in neural stem cell proliferation and neuronal differentiation. Here, we show that miR-1290 is significantly downregulated during neuronal differentiation in reprogrammed induced pluripotent stem cell- (iPSC-) derived neurons obtained from idiopathic autism spectrum disorder (ASD) patients.

Mobile phone conversation distraction: Understanding differences in impact between simulator and naturalistic driving studies.

A current issue within the driver distraction community centres around different findings regarding the impact of mobile phone conversation on driving found in driving simulators versus instrumented vehicles employed in real-world naturalistic driving studies (NDSs). This paper compares and contrasts the two types of studies and aims to provide reasons for the differences in findings that have been documented. A comprehensive review of literature and consultations with human factors experts highlighted that simulator studies tend to show degradation in driving performance, suggestive of increased crash risk as a result of mobile phone conversation.

ROS management is mediated by ascorbate-glutathione-α-tocopherol triad in co-ordination with secondary metabolic pathway under cadmium stress in Withania somnifera.

Being static, plants are frequently exposed to various essential and non-essential heavy metals from the surroundings. This exposure results in considerable ROS generation leading to oxidative stress, the primary response of the plants under heavy metal stress. Withania somnifera is a reputed Indian medicinal plant in Ayurveda, having various pharmacological activities due to the presence of withanolides.

Effectiveness of oral health education program using braille text in a group of visually impaired children-before and after comparison trial.

Context: Vision is the most important sense for interpreting the world and when sight is impaired, especially in childhood it can have detrimental effects on one's life. To maintain the oral health status of such group requires special approach.

Aim: The aim of this study is to evaluate the impact of Braille text and verbal, oral hygiene instructions on the oral health status of visually impaired children.

Three Co(II) Metal-Organic Frameworks with Diverse Architectures for Selective Gas Sorption and Magnetic Studies.

Three Co(II) metal-organic frameworks, namely, {[Co(L)(OBA)(HO)]· xG} (1), {[Co(L)(OBA)]· xG} (2), and {[Co(L)(OBA)(HO)]·DMA· xG} (3) [where L = 2,5-bis(3-pyridyl)-3,4-diaza-2,4-hexadiene, HOBA = 4,4'-oxybisbenzoic acid, DMF = dimethylformamide, DMA = dimethylacetamide, and G denotes disordered guest molecules], have been synthesized under diverse reaction conditions through self-assembly of a bent dicarboxylate and a linear spacer with a Co(II) ion. While 1 is crystallized at room temperature in DMF to form a 2D layer structure, 2 is formed by the assembly of similar components under solvothermal conditions with a 3D network structure. On the other hand, changing the solvent to DMA, 3 could be crystallized at room temperature with a 3D architecture.

Correction: Characterizing multicity urban traffic conditions using crowdsourced data.

[This corrects the article DOI: 10.1371/journal.pone.

Results of Supracondylar "V" Osteotomy for the Correction of Genu Valgum Deformity.

Background: Medial close wedge, lateral open wedge, dome and "V" osteotomies are the commonly to correct the genu valgum (GV) deformity. However, the ideal method for the correction of coronal plane deformity is controversial. This prospective study is to evaluate the functional and radiological result of supracodylar "V" osteotomy to correct GV deformity.

Genetic relationship, population structure analysis and allelic characterization of flowering and maturity genes , , and among 90 Indian soybean landraces.

A set of 90 Indian soybean landraces were analysed for polymorphism at 43 SSRs and five allele specific markers of four major genes involved in regulating flowering and photoperiod response. A total of 42 polymorphic SSRs had amplified 126 alleles which served as raw data for estimation of genetic relationship and population structure among 90 accessions. Rare alleles of four and three SSRs were detected in accessions IC18768 and IC15089, respectively.

Quantification of a legume begomovirus to evaluate soybean genotypes for resistance to yellow mosaic disease.

Mungbean yellow mosaic India virus (MYMIV) infecting soybean and other legumes causes yellow mosaic disease (YMD). Evaluation of soybean genotypes for YMD resistance involves field screening at disease hot spots or in a protected environment using infectious clones or viruliferous whiteflies as sources of virus inocula. Development of efficient virus inoculation and quantification protocols to screen soybean genetic stocks against YMD is imperative for breeding resistant varieties.

Characterizing multicity urban traffic conditions using crowdsourced data.

Road traffic congestion continues to manifest and propagate in cities around the world. The recent technological advancements in intelligent traveler information have a strong influence on the route choice behavior of drivers by enabling them to be more flexible in selecting their routes. Measuring traffic congestion in a city, understanding its spatial dispersion, and investigating whether the congestion patterns are stable (temporally, such as on a day-to-day basis) are critical to developing effective traffic management strategies.