Publications by authors named "Chanceline Bilounga-Ndongo"

Background: Infection prevention and control (IPC) helps prevent disease transmission in healthcare facilities. There is a dearth of information on the implementation of IPC during the COVID-19 outbreak in Cameroon using the recommended WHO COVID-19 IPC scorecard tool. The present study assessed healthcare facilities' compliance to IPC by continuous assessments, with an evaluation of the tool using the hierarchy of control theory.

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Objectives: Infection prevention and control (IPC) contributes to the reduction of healthcare associated infections. Notwithstanding the global attention with available guidelines and tools, low- and middle-income countries (LMICs) still struggle to put into place effective IPC programmes. Here, we use a socioecological approach to summarize the findings of a recent workshop on the implementation of IPC activities in Cameroon.

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Article Synopsis
  • - High seroreactivities to Ebola (EBOV) and Sudan (SUDV) orthoebolavirus antigens were found in rural populations of Cameroon, particularly among Pygmies, despite no reported outbreaks.
  • - The study did not find a direct link between the risk of NHP (nonhuman primates) bites and seroreactivity, but indicated that exposure may vary among different ethnic groups.
  • - These findings suggest a possible silent circulation of orthoebolaviruses or other unknown filoviruses in forested regions, emphasizing the need for increased surveillance and research in these areas.
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Background: Respiratory syncytial virus (RSV) is one of the major pathogens frequently associated with severe respiratory tract infections in younger children and older adults globally. There is an unmet need with a lack of routine country-specific databases and/or RSV surveillance systems on RSV disease burden among adults in most low- and middle-income countries, including Cameroon. We aim to estimate the adult RSV burden needed to develop a framework for establishing an RSV surveillance database in Cameroon.

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Objectives: There is data scarcity on the overall effects of pneumococcal conjugate vaccines (PCVs) on otitis media (OM) in low- and middle-income countries. The impact of the 13-valent PCV (PCV13) program on OM was evaluated in Cameroon where infant vaccination was implemented in July 2011 using a 3-dose primary series at 6, 10 and 14 weeks of age.

Methods: Through community-based surveillance, we used a retrospective cohort study design to assess OM prevalence among PCV13-vaccinated children aged 24 to 36 months in 2015.

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Background: Antimicrobial resistance (AMR) remains one of the leading threats to global public health and this may increase following COVID-19 pandemic. This is particularly the case in Africa where regulations on antimicrobial usage are weak. This protocol outlines the steps to undertake a systematic review to synthesize evidence on drivers of AMR and evaluate existing approaches to strengthening antimicrobial stewardship (AMS) programs in Sub-Saharan Africa (SSA).

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  • - Infection with simian foamy viruses (SFVs) can result in lifelong infections in humans but typically do not cause severe disease or human-to-human transmission, making them an interesting case study for zoonotic retroviruses.
  • - Researchers studied neutralizing antibodies (nAbs) in SFV-infected individuals from Central Africa, focusing on the viral envelope protein's variable regions, which are crucial for nAb targeting and do not exhibit major immune escape mechanisms.
  • - Three primary regions crucial for nAb binding were identified, and they play a role in preventing the virus from changing shape or binding to human cells, effectively blocking infection.
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Objectives: To formatively evaluate the HIGHER Women consortium's Mentor Protégée Program (MPP) and derive lessons for successful African women scientist mentorship.

Design: Desk review of program documents and cross-sectional surveys of mentors and protégées.

Setting: All 10 regions of Cameroon.

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  • - Central Africa, particularly Cameroon, has a high prevalence of HTLV-1, yet no preventive measures are in place to combat its transmission, which can occur through various means such as sexual contact, mother-to-child, and contaminated blood products.
  • - A study conducted from 2019 to 2021 found that out of 3,400 participants, the HTLV-1 infection rate was 1.1%, with higher risks associated with factors like Pygmy ethnicity, a history of surgery, and bites from nonhuman primates.
  • - The findings indicate both iatrogenic (from healthcare practices) and zoonotic (from animals) transmission of HTLV-1, highlighting the need for further research to develop public health
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Article Synopsis
  • Zoonotic simian foamy viruses (SFV) lead to lifelong infections in humans but do not cause severe health issues or human-to-human transmission.
  • The study investigated the immune response of SFV-infected individuals, focusing on their ability to produce neutralizing antibodies against both cell-free virus and potential cell-to-cell transmission.
  • Despite finding that these antibodies can bind to the infected cells, the research concluded that they do not prevent the cell-to-cell spread of SFV, indicating different mechanisms of viral transmission.
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Background: Routine Health Information Systems (RHIS) of low-income countries function below the globally expected standard, characterised by the production and use of poor-quality data, or the non-use of good quality data for informed decision making. This has negatively influenced the health service delivery and uptake. This study focuses on identifying the factors associated with the performance of RHIS of the health facilities (HF) in Yaoundé, so as to guide targeted RHIS strengthening.

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Background: Management of health data and its use for informed-decision making is a challenging health sector aspect in developing countries. Monitoring and evaluation of health interventions for meeting health-related Sustainable Development Goals (SDGs), and Cameroon Health Sector Strategy (HSS) targets is facilitated through evidence-based decision-making and public health action. Thus, a routine health information system (RHIS) producing quality data is imperative.

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Background: The International Health Regulations state that early detection and immediate reporting of unusual health events is important for early warning and response systems.

Objective: To describe a pilot surveillance program established in health facilities in Yaoundé, Cameroon in 2017 which aimed to enable detection and reporting of public health events.

Methods: Cameroon's Ministry of Health, in partnership with the US Centers for Disease Control and Prevention, Cameroon Pasteur Center, and National Public Health Laboratory, implemented event-based surveillance (EBS) in nine Yaoundé health facilities.

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Background: Zoonotic simian foamy viruses (SFVs) establish persistent infections in humans, for whom the long-term consequences for health are poorly described. In this study, we aimed to characterize blood-cell phenotypes and plasma biomarkers associated with gorilla SFV infection in humans.

Methods: We used a case-control design to compare 15 Cameroonian hunters infected with gorilla SFV (cases) to 15 controls matched for age and ethnicity.

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Hepatitis B virus (HBV) infection is hyperendemic in Cameroon, and healthcare workers (HCWs) are at high risk of infection. We aimed to assess prevalence, risk factors and vaccine coverage of HBV infection among HCWs in Cameroon. We conducted a cross-sectional study in 16 hospitals across all regions of Cameroon.

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Background: A spillover of simian foamy virus (SFV) to humans, following bites from infected nonhuman primates (NHPs), is ongoing in exposed populations. These retroviruses establish persistent infections of unknown physiological consequences to the human host.

Methods: We performed a case-control study to compare 24 Cameroonian hunters infected with gorilla SFV and 24 controls matched for age and ethnicity.

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