Publications by authors named "Chance C Sine"
Article Synopsis
- Researchers are studying drugs called replication checkpoint modulators (RCMs) that could help treat tough ovarian cancer, but they are not very effective by themselves.
- When these drugs are used on cancer cells, they change certain proteins inside the cells, which makes them struggle to divide and can lead to cell death.
- The study shows that these drugs can help shrink tumors even in stubborn cases, meaning they could be useful for patients with this type of cancer.
Super-enhancers regulate genes with important functions in processes that are cell type-specific or define cell identity. Mouse embryonic fibroblasts establish 40 senescence-associated super-enhancers regardless of how they become senescent, with 50 activated genes located in the vicinity of these enhancers. Here we show, through gene knockdown and analysis of three core biological properties of senescent cells that a relatively large number of senescence-associated super-enhancer-regulated genes promote survival of senescent mouse embryonic fibroblasts.
View Article and Find Full Text PDFImmune cells identify and destroy damaged cells to prevent them from causing cancer or other pathologies by mechanisms that remain poorly understood. Here, we report that the cell-cycle inhibitor p21 places cells under immunosurveillance to establish a biological timer mechanism that controls cell fate. p21 activates retinoblastoma protein (Rb)–dependent transcription at select gene promoters to generate a complex bioactive secretome, termed p21-activated secretory phenotype (PASP).
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