The effect of bupivacaine on myocardial tissue hypoxia and acidosis during ventricular fibrillation.

Unlabelled: Previously we observed that during bupivacaine-induced circulatory collapse, myocardial tissue pH declined more slowly than expected. Here we evaluated the effect of bupivacaine on myocardial acidosis induced by ventricular fibrillation. Sixteen dogs were anesthetized with 1.