Publications by authors named "ChanWoo Park"

Purpose: Hip resurfacing arthroplasty (HRA) is recommended for younger patients seeking higher levels of activity. However, femoroacetabular cup impingement (FACI) between the femoral neck and acetabular prosthesis remains a concern. This study aimed to determine the incidence, risk factors, and prognostic consequences of FACI after HRA.

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Polar tip growth in plants occurs only in root hairs and pollen tubes. In particular, root hair growth is considered very important in the growth of plants, as it is critical for water and nutrient absorption. Polar tip growth is regulated by various factors, including plant hormones such as abscisic acid (ABA) and gibberellin (GA) and cell wall modifications.

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Article Synopsis
  • Researchers synthesized magnesium, calcium, and barium heteroleptic complexes from bis(trimethylsilyl)amide compounds through substitution reactions with specific ligands.
  • The resulting complexes were characterized using techniques like FTIR, NMR, thermal analysis, and elemental analysis, confirming their distinct structures.
  • Additionally, the complexes underwent trimethylsilylation reactions due to increased acidity from the presence of electron-withdrawing hfac ligands.
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This study describes the synthesis of germanium and tin complexes Ge(mdpaS) (), Ge(edpaS) (), Ge(bdpaS) (), Ge(empaS) (), Sn(mdpaS) (), Sn(edpaS) (), Sn(bdpaS) (), and Sn(empaS) () (mdpaSH = ()--methoxy-2,2-dimethylpropanimidothioic acid; edpaSH = ()--ethoxy-2,2-dimethylpropanimidothioic acid; bdpaSH = ()--(tert-butoxy)-2,2-dimethylpropanimidothioic acid; empaSH = ()--ethoxy-2-methylpropanimidothioic acid), using newly designed -alkoxy thioamide ligands as precursors for metal chalcogenide materials. All complexes were characterized using various analytical techniques, and the single-crystal structures of complexes and revealed a distorted seesaw geometry in the monomeric SnL form. Thermogravimetric (TG) curves showed differences between Ge compounds, which exhibited single-step weight losses, and Sn compounds, which exhibited multistep weight losses.

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Background: Oligomeric amyloid beta (oAβ) is a toxic factor that acts in the early stage of Alzheimer's disease (AD) and may initiate the pathologic cascade. Therefore, detecting oAβ has a crucial role in the early diagnosis, monitoring, and treatment of AD.

Purpose: The purpose of this study was to evaluate MRI signal changes in different mouse models and the time-dependent signal changes using our novel gadolinium (Gd)-dodecane tetraacetic acid (DOTA)- ob5 aptamer contrast agent.

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Background: Autologous costal cartilage has gained widespread acceptance as an important material for ear reconstruction in patients with microtia. Despite its recognition as being "worth the trade-off," attention should be directed toward donor-site deformities. This systematic review focused on existing English literature related to microtia reconstruction and aimed to reveal the incidence of chest wall deformities and assess the effectiveness of the various proposed surgical techniques aimed at reducing donor-site morbidities.

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Background: We previously reported the mean 6-year outcomes of total hip arthroplasty (THA) using fourth-generation ceramic-on-ceramic (CoC) articulations. With extended observations, this study aimed to report the mean 12-year outcomes focusing on bearing-related complications of CoC THA.

Methods: We reviewed primary CoC THAs performed between May 2009 and April 2012 at a single institution.

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Article Synopsis
  • - This study synthesizes 12 new germanium complexes using β-diketonate and -alkoxy carboxamidate ligands to serve as precursors for germanium oxide (GeO) via atomic layer deposition (ALD).
  • - Various ligands, such as acetylacetone (acacH) and several alkoxy carboxamidates, led to the formation of complexes that were characterized using thermogravimetric analysis and X-ray diffraction, revealing their unique molecular structures.
  • - An effective ALD process was established for growing GeO films with Ge(tmhd)Cl as the precursor, achieving self-limiting growth at deposition temperatures between 300 and 350 °C, resulting in amor
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Background: Although the modular sleeve concept for femoral implants has several advantages, studies reporting on greater than 20-year outcomes are limited. This study aimed to report the mean 23-year results of total hip arthroplasty (THA) using a modular stem with metaphyseal fixation sleeve.

Methods: This study reviewed primary THAs performed using a modular stem between October 1994 and April 1998.

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The van der Waals interaction between colloids and nanoparticles is one of the key components to understanding particle aggregation, attachment, and assembly. While the ubiquity of anisotropic particle shapes and surface roughness is well-recognized in nanocrystalline materials, the effects of both on van der Waals forces and torques have not been adequately investigated. In this study, we develop a numerical scheme to determine the van der Waals forces and torques between cubic particles with multiple configurations and relative orientations.

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Background: The combination of propofol and remifentanil results in better surgical field conditions during endoscopic sinus surgery than inhalation anesthesia. This study compared surgical field conditions between two groups receiving low or high concentration of remifentanil and hemodynamic variables using non-invasive cardiac monitoring.

Methods: Fifty-four patients between ASA I or II, were randomly assigned to either the high-concentration remifentanil group (HR), effect-site concentration of 8 ng/mL or the low-concentration remifentanil group(LR), effect-site concentration of 4 ng/mL.

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Childhood neglect and/or abuse can induce mental health conditions with unknown mechanisms. Here, we identified stress hormones as strong inducers of astrocyte-mediated synapse phagocytosis. Using in vitro, in vivo, and human brain organoid experiments, we showed that stress hormones increased the expression of the Mertk phagocytic receptor in astrocytes through glucocorticoid receptor (GR).

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Novel barium heteroleptic complexes were synthesized through the substitution of the bis(trimethylsilyl)amide of Ba(btsa)·2DME with aminoalkoxide and β-diketonate ligands. Compounds [Ba(ddemap)(tmhd)] () and [Ba(ddemmp)(tmhd)] () were obtained and analyzed through Fourier transform infrared spectroscopy, nuclear magnetic resonance, thermogravimetric analysis, and elemental analysis (ddemapH = 1-(dimethylamino)-5-((2-(dimethylamino)ethyl) (methyl)amino)pentan-3-ol and ddemmpH = 1-(dimethylamino)-5-((2-(dimethylamino)ethyl) (methyl)amino)-3-methylpentan-3-ol). In single-crystal X-ray crystallography, complex exhibited a dimeric structure with μ-O bonds of the ddemap ligand.

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Background: Periprosthetic femoral fractures (PFFs) remain a major concern following cementless total hip arthroplasty (THA). This study aimed to evaluate the association between different types of cementless tapered stems and the risk of postoperative PFF.

Methods: A retrospective review of primary THAs performed at a single center from January 2011 to December 2018 included 3,315 hips (2,326 patients).

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Strontium β-diketonate complexes were synthesized by the substitution reaction of the bis(trimethylsilyl) amide of Sr(btsa)·2DME with an ethereal group and β-diketonate ligands. The compounds [Sr(tmge)(btsa)] (), [Sr(tod)(btsa)] (), Sr(tmgeH)(tfac) (), Sr(tmgeH)(acac) (), Sr(tmgeH)(tmhd) (), Sr(todH)(tfac) (), Sr(todH)(acac) (), Sr(todH)(tmhd) (), Sr(todH)(hfac) (), Sr(dmts)(hfac) (), [Sr(mee)(tmhd)] (), and Sr(dts)(hfac)·DME () were obtained and analyzed by various techniques, including FT-IR, NMR, TGA (thermogravimetric analyses), and elemental analysis. Complexes , , , , , , and were further structurally confirmed by single-crystal X-ray crystallography, where complexes and showed dimeric structures with μ-O bonds of ethereal groups or tmhd ligands, and complexes , , , , and displayed monomeric structures.

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Article Synopsis
  • - Iliopsoas tendinopathy (IPT) is a condition that can cause ongoing groin pain after total hip arthroplasty (THA), and this study aimed to analyze its characteristics, incidence, risk factors, and treatment outcomes post-surgery.
  • - The study reviewed 1,602 THA procedures and found IPT in 3.3% of patients, revealing that those with IPT experienced greater leg lengthening and more cases of anteroinferior cup prominence compared to those without IPT.
  • - Treatment results showed that patients who underwent arthroscopic tenotomy had significant pain relief, while only a small percentage of those treated non-operatively reported improvement, indicating tenotomy's effectiveness for addressing IPT-related groin
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Background: Cementing a new liner into a secure, well-positioned metallic shell can be a less-invasive strategy in revision total hip arthroplasty (THA). This study aimed to report the mean 14-year outcomes of cementing highly cross-linked polyethylene (XLPE) liners into well-fixed acetabular shells in revision THAs.

Methods: This study reviewed a single-surgeon series of cementing XLPE liners into well-fixed acetabular components.

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Introduction: A residual fracture gap after intramedullary nailing is a known risk factor for delayed union and non-union. This study aimed to report the outcomes of a forward-striking technique to reduce fracture gaps during long cephalomedullary nailing in subtrochanteric femoral fractures (SFFs).

Methods: A retrospective cohort study was conducted on patients with SFFs treated in a single institution between February 2013 and October 2018.

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Background: Tapered modular stems are increasingly used in revision total hip arthroplasty (THA) with deficient femoral bone stock. This study aimed to report the long-term outcomes of revision THA using a tapered and fluted modular stem.

Methods: Between December 1998 and February 2006, 113 revision THAs (110 patients) were performed with a tapered and fluted modular stem at a single institution.

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Nanozyme-based dye degradation methods are promising for the remediation of water pollution. Though Pd nanoparticles (PdNPs) are known to act as nanozymes, their dye degradation capability has not been investigated. Low nanozyme activities, easy aggregation, difficulties in recovery and reuse are the major challenges in achieving this.

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Many statistical methods for pathway analysis have been used to identify pathways associated with the disease along with biological factors such as genes and proteins. However, most pathway analysis methods neglect the complex nonlinear relationship between biological factors and pathways. In this study, we propose a Deep-learning pathway analysis using Hierarchical structured CoMponent models (DeepHisCoM) that utilize deep learning to consider a nonlinear complex contribution of biological factors to pathways by constructing a multilayered model which accounts for hierarchical biological structure.

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Article Synopsis
  • Early detection of bone tumors in the proximal femur is essential for effective treatment, prompting this study to develop an AI model for classification using plain radiographs.
  • The study used 538 hip radiographs, training a deep learning model to differentiate between benign, malignant, and tumor-free images, achieving a high diagnostic accuracy of 0.853 compared to the average accuracy of four human doctors.
  • The AI model showed superior performance with a high AUROC score (0.953), indicating its potential to lessen diagnostic errors, especially by non-specialist doctors in the field of musculoskeletal oncology.
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Cytochrome P450 (CYP) catalyzes a wide variety of monooxygenation reactions in plant primary and secondary metabolisms. Land plants contain CYP703, belonging to the CYP71 clan, which catalyzes the biochemical pathway of fatty acid hydroxylation, especially in male reproductive tissues. Korean/Asian ginseng ( Meyer) has been regarded as one of important medicinal plant for a long time, however the molecular mechanism is less known on its development.

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Background: Recurrent dislocation is a difficult complication after total hip arthroplasty (THA). This study aimed to report the clinical and radiographic outcomes of revision THA using the modular dual mobility (MDM) acetabular system to treat recurrent dislocation.

Methods: Between March 2015 and February 2019, 34 revision THAs were performed using the MDM system for treating recurrent dislocation in a single institution.

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