Exosomal miR-365b-5p derived from keratinocyte promotes melanogenesis by directly targeting GLI2.

In previous studies, we analyzed that exosomal microRNA (miRNA) secreted by keratinocytes exposed to Ultraviolet B(UVB) light regulate melanogenesis in melanocytes. Through functional experiments, it was determined that a subgroup of exosomal miRNAs had distinct impacts on melanogenesis. In the current study, we focused on hsa-miR-365b-5p which founded upregulated in UVB-irradiated keratinocyte exosomes and confirmed to exert enhancing effects on melanogenesis in human melanocyte.

Comprehensive Analysis of Exosomal MicroRNAs Derived from UVB-Irradiated Keratinocytes as Potential Melanogenesis Regulators.

The exosomes derived from keratinocytes can have a substantial impact on melanogenesis by influencing melanocytes. MicroRNAs (miRNAs) encapsulated within exosomes are implicated in the control of melanogenesis, particularly when under the influence of UVB irradiation. This investigation explores UVB-induced exosomal miRNAs from keratinocytes as potential regulators of melanogenesis.

Phosphorylation of glucocorticoid receptor induced by 16-kauren-2-beta-18, 19-triol decreases expression of Melanophilin through JNK signalling.

16-kauren-2-beta-18, 19-triol (16-kauren) is a natural diterpenoid substance derived from Asteraceae psiadia punctulata, a small tropical shrub in Africa and Asia, and it can reduce Mlph expression without affecting the expression of Rab27a and MyoVa in melanocytes. Melanophilin (Mlph) is an important linker protein in the melanosome transport process. However, the signal transduction pathway for the regulation of Mlph expression has not been fully established.