Quantitative analysis of multivalent interactions of carbohydrate-encapsulated gold nanoparticles with concanavalin A.

Multivalent interactions between carbohydrate-encapsulated gold nanoparticles and Con A are found with high affinity and specificity.

Selective binding of mannose-encapsulated gold nanoparticles to type 1 pili in Escherichia coli.

The synthesis, characterization and biological application of mannose encapsulated gold nanoparticles (m-AuNP) are reported. m-AuNP is well dispersed and very stable without aggregation in the media of broad ion strength and pH ranges. The selective binding of m-AuNP to the mannose adhesin FimH of bacterial type 1 pili is demonstrated using transmission electron microscopy.