Publications by authors named "Chan-Na Zhao"
Article Synopsis
- The study investigates how long-term exposure to particulate matter (PM) affects arthritis and rheumatoid arthritis risk, using data from over 18,000 individuals aged 45 and older.
- Results indicate that exposure to PM, particularly black carbon, negatively impacts the likelihood of developing these conditions, with a notable increase in risk correlating with higher PM levels.
- The research also considers the relationship between PM and green space, confirming an impact from both factors but highlighting the need for more investigation into the mechanisms behind these associations.
Objective: To evaluate the associations between biological aging, metabolic heterogeneity of obesity, and rheumatoid arthritis (RA).
Methods: This prospective cohort study analyzed 268,184 individuals from the UK Biobank. Biological age was estimated using phenotypic age (PhenoAge), Klemera-Doubal methods (KDM-BA), and telomere length.
The study aimed to investigate the pattern and trend of Musculoskeletal (MSK) disorders in people aged 5-19 years from 1990 to 2021. The data was sourced from the Global Burden of Disease study 2021. The Age-standardized DALYs rates (ASDR), age-standardized mortality rate (ASMR), age-standardized prevalence rate (ASPR), and age-standardized incidence rate (ASIR) and their corresponding average annual percent change (AAPC) for MSK disorders were evaluated by sex, region, and sociodemographic index (SDI) quintiles.
View Article and Find Full Text PDFIntroduction: Air pollution is speculated to increase the risk of Coronavirus disease-2019 (COVID-19). Nevertheless, the results remain inconsistent and inconclusive. This study aimed to explore the association between ambient air pollution (AAP) and COVID-19 risks using a meta-analysis with meta-regression modelling.
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- The study aimed to analyze the age-standardized prevalence rate (ASPR) and trends of osteoarthritis (OA) in various regions globally from 1990 to 2019.
- According to the findings, knee OA is particularly prevalent in Asia, while America has the highest overall OA burden, especially for hip and hand OA.
- The research indicates significant changes in OA prevalence across different continents, highlighting the need for effective prevention and management strategies to tackle modifiable risk factors.
Article Synopsis
- - MicroRNAs (miRNAs) are non-coding RNA molecules that regulate gene expression by binding to messenger RNAs (mRNAs), playing a crucial role in autoimmune diseases.
- - Changes in miRNA expression levels have been linked to various autoimmune conditions, making them potential biomarkers and therapeutic targets for treatments.
- - This review focuses on the biological functions of miRNAs, their involvement in conditions like rheumatoid arthritis and systemic lupus erythematosus, as well as the therapeutic strategies and challenges in this area.
Background: Short-term exposure to air pollution may trigger symptoms of drug-resistant tuberculosis (DR-TB) through stimulating lung tissue, damaging tracheobronchial mucosa, the key anti-mycobacterium T cell immune function, and production and release of inflammatory cytokines.
Objective: To investigate the association between acute exacerbations of DR-TB and short-term residential exposure to air pollutants (PM, PM, SO, NO, CO and O) based on a large prospective cohort in Anhui Province, China.
Method: Patients were derived from a prospective cohort study of DR-TB in Anhui Province.
Objective: This study aimed to examine rheumatoid arthritis (RA) risk associated with hormonal and reproductive factors in women from the large cohort of the UK Biobank.
Methods: Data on hormonal and reproductive factors in women were collected from a prospective cohort of 223 526 UK Biobank participants. The potential relationship between reproductive factors and RA risk was assessed using restricted cubic spline.
Article Synopsis
- The study investigates the relationship between heavy metal exposure and two specific systemic inflammation indexes (SII and SIRI), utilizing data from over 4,000 U.S. adults.
- Various statistical methods were employed to analyze the effects of 19 different metals, revealing significant correlations between metal exposure and increased levels of SII and SIRI.
- The research highlights that serum albumin mediates some of these associations, particularly noting that exposure to metals like cobalt, cadmium, and arsenic raised inflammatory index levels, with variations observed among different demographic groups.
Osteoarthritis (OA) is a threat to public health issue with high morbidity and disability worldwide. However, unequivocal evidence on the link between air pollution and OA remains little, especially in multi-study sites. This study aimed to explore the relationship between short-term exposure to main air pollutants and the risk of OA outpatient visits in multi-study sites.
View Article and Find Full Text PDFBackground: Sclerostin, a regulator of bone metabolism and vascular calcification involved in regulating the Wnt/β-catenin signaling pathway, has been shown to be involved in the pathogenesis of rheumatoid arthritis (RA). However, current results regarding the circulating sclerostin level of RA patients are debatable. This study aimed to evaluate the circulating level of sclerostin in RA patients and briefly summarize its role.
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- The study investigates the link between the PER2 gene and systemic lupus erythematosus (SLE), focusing on specific genetic variations (SNPs) that may influence susceptibility to the disease.
- A total of 492 SLE patients and 493 healthy individuals were analyzed using advanced genotyping techniques, revealing significant differences in a particular SNP (rs11894491) between the two groups.
- The findings suggest that variations in the PER2 gene could play a role in both the risk of developing SLE and its clinical symptoms, highlighting its importance in understanding the disease's mechanisms.
Air pollution is an important risk factor for autoimmune diseases, but its association with the recurrence of rheumatoid arthritis (RA) remains unclear so far. This study aimed to investigate the short-term association between traffic-related air pollutants and hospital readmissions for RA in Hefei, China. Data on daily hospital readmissions for RA and traffic-related air pollutants, including particulate matter (PM and PM), nitrogen dioxide (NO), and carbon monoxide (CO), from 2014 to 2018 were retrieved.
View Article and Find Full Text PDFBackground: Meteorin-like (Metrnl) is a newly identified adipokine implicated in the pathogenesis of type 2 diabetes mellitus (T2DM), yet data on the circulating levels of Metrnl in patients with T2DM are controversial. To derive a more precise estimation on circulating Metrnl levels in T2DM patients, we conducted this meta-analysis.
Methods: The existing studies on the circulating levels of Metrnl in patients with T2DM published up to 16 January 2020 were comprehensively retrieved from PubMed, Web of Science, EMBASE, and The Cochrane library database.
Article Synopsis
- The study aimed to investigate the relationship between ambient temperature and hospital admissions for systemic lupus erythematosus (SLE) in Hefei City, China, over a ten-year period.
- Researchers analyzed daily SLE admissions data alongside meteorological data, employing a specific statistical model to account for various factors like seasonality and humidity.
- The results indicated no connection between temperature and first-time admissions, but a significant association was found between low temperatures and increased re-admissions for SLE, suggesting that SLE patients should stay warm to potentially reduce hospital visits.
Objective: To investigate the temporal trends in mortality and disease burden of injuries in Anhui province from 2008 to 2017, so as to provide reference for injury control and prevention.
Methods: Data of mortality were collected from 9 national surveillance points in Anhui province during 2008-2017 in the Information System for Death Cause Register and Management. The surveillance data were analyzed by using crude mortality, standardized mortality rate (SMR), potential year of life lost (PYLL), PYLL rate (PYLLR), and average of year life lost (AYLL).
In a previous study, we have reported an increased plasma midkine (MK) and pleiotrophin (PTN) concentrations in patients with systemic lupus erythematosus (SLE) and the increase in MK and PTN associated with inflammatory cytokines interleukin (IL)-17 level and some clinical manifestations, suggesting the underlying association of MK and PTN with SLE. This study was conducted to investigate the association between common single-nucleotide polymorphisms (SNPs) in the and gene and SLE susceptibility. A total of 989 subjects (496 SLE patients and 493 healthy controls) were included and genotyped for three SNPs and seven SNPs in using improved multiple ligase detection reaction (iMLDR).
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- Previous studies on circulating interleukin-17 (IL-17) levels in systemic lupus erythematosus (SLE) have yielded mixed results, prompting further investigation through this meta-analysis.
- By reviewing 1872 articles, the study found that SLE patients had significantly elevated IL-17 levels compared to healthy controls, with specific trends based on ethnicity, age, disease duration, and measurement methods.
- The findings indicate that while SLE patients generally present higher IL-17 levels, this increase is influenced by various factors, suggesting the need for careful evaluation in future research.
Article Synopsis
- The study aimed to explore the links between melatonin pathway gene SNPs and the risk of developing systemic lupus erythematosus (SLE) using a cohort of 495 patients and 493 healthy controls.
- Two specific SNPs (rs8150 and rs3760138) were identified as significant; rs8150 lowered SLE risk for certain carriers, while rs3760138 increased the risk for others.
- The findings suggest that melatonin pathway genes may play a role in the susceptibility to SLE and influence specific clinical symptoms, highlighting the importance of further research in this area.
Article Synopsis
- * Results showed that SLE patients had significantly higher PTX3 levels compared to controls, with a pooled effect size indicating this difference.
- * Subgroup analyses revealed that factors like age, ethnicity, disease activity, and sample type influenced PTX3 levels in SLE patients.
Objective: Although patients with psoriasis frequently report seasonal changes in their symptoms, the seasonality of psoriasis has rarely been explored. This study aims to investigate the seasonal pattern of and global public interest in psoriasis using Google search data.
Methods: Internet search data were collected from Google Trends.
Article Synopsis
- - The study investigates the levels of 25-hydroxyvitamin D (25(OH)D) in patients with systemic lupus erythematosus (SLE) to determine its association with SLE risk and severity.
- - A meta-analysis of 19 articles reveals that SLE patients have significantly lower circulating 25(OH)D levels compared to healthy individuals, with certain subgroups (e.g., those with higher disease activity or no vitamin D supplementation) showing more pronounced deficiencies.
- - The analysis indicates that vitamin D status can influence SLE risk, where both deficiency and insufficiency increase SLE risk significantly, while sufficient levels appear to slightly mitigate the risk.
Article Synopsis
- - A study investigated the levels of two semaphorins, Sema3A and Sema7A, in patients with systemic lupus erythematosus (SLE) and compared them to healthy controls and other autoimmune diseases like rheumatoid arthritis (RA) and Sjögren's syndrome (SS).
- - Results showed that Sema3A and Sema7A levels were lower in SLE patients, while RA patients had higher levels of Sema3A; SS patients displayed increased Sema3A and decreased Sema7A.
- - The study found significant differences in Sema3A and Sema7A levels between the groups, with correlations to specific antibodies, highlighting their potential importance in understanding and
Plasma galectin-3 levels do not differ in systemic lupus erythematosus patients.
Int J Rheum Dis
October 2019
Article Synopsis
- - The study aimed to analyze plasma galectin-3 levels in systemic lupus erythematosus (SLE) patients and compare them with healthy individuals, involving 90 patients and 90 controls of similar age and gender distribution.
- - Results showed no significant differences in galectin-3 levels between SLE patients and controls or among different SLE activity levels and nephritis status, indicating a potential lack of relationship between galectin-3 and these clinical features.
- - Although there was a negative correlation between galectin-3 levels and immune globulin M, overall findings suggest that galectin-3 may not play a significant role in SLE, highlighting the need for further research.