Reliability of displayed tidal volume in infants and children during dual-controlled ventilation.

Objective: Previous studies have shown a significant difference between ventilator-measured tidal volume and actual-delivered tidal volume. However, these studies used external methods for measurement of compression volume. Our objective was to determine whether tidal volume could be accurately measured at the expiratory valve of a conventional ventilator using internal computer software to compensate for circuit compliance with a dual control mode of ventilation.

WITHDRAWN: Reliability of displayed tidal volume in infants and children during dual controlled ventilation.

Ahead of Print article withdrawn by publisher: OBJECTIVE:: Previous studies have shown significant difference between ventilator-measured tidal volume and actual-delivered tidal volume. However, these studies utilized external methods for measurement of compression volume. Our objective was to determine whether tidal volume could be accurately measured at the expiratory valve of a conventional ventilator using internal computer software to compensate for circuit compliance, with a dual control mode of ventilation.

Diets containing soy protein isolate increase hepatic CYP3A expression and inducibility in weanling male rats exposed during early development.

Hepatic CYP3A enzymes were studied in weanling male Sprague-Dawley rats exposed to diets from gestational d 4 in which the sole protein source was either casein (CAS) or soy protein isolate (SPI). At age 25 d, rats were gavaged with corn oil or one of the CYP3A inducers, dexamethasone (DEX) and clotrimazole (CLT), at a dose of 50 mg/kg. Little CYP3A1 (CYP3A23), CYP3A2, or CYP3A9 mRNA was observed in CAS-fed weanling rats but CYP3A18 mRNA was readily detectable in Northern blots.