Publications by authors named "Chan Song Park"
Article Synopsis
- Proguanil is metabolized into its active form, cycloguanil, through the OCT1 transporter and CYP2C19 enzyme, with genetic variations affecting this process.
- The study investigated the impact of specific genetic differences (SLC22A1 polymorphisms) on how the drug is processed in the body, focusing on a Korean population.
- The results indicate that individuals with the CT genotype of the SLC22A1 polymorphism experience higher levels of proguanil but lower levels of cycloguanil, due to reduced hepatic uptake of proguanil.
The aerial surfaces of terrestrial plants are covered by a cuticular wax layer, which protects the plants from environmental stresses such as desiccation, high irradiance, and UV radiation. Cuticular wax deposition is regulated in an organ-specific manner; Arabidopsis stems have more than 10-fold higher wax loads than leaves. In this study, we found that WRINKLED4 (WRI4), encoding an AP2/ERF (ethylene-responsive factor) transcription factor (TF), is predominantly expressed in stem epidermis, is upregulated by salt stress, and is involved in activating cuticular wax biosynthesis in Arabidopsis stems.
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