Locally Isolated Species Have Broad Spectrum Biocontrol Activities against the Wood Rot Fungal Species through Both Volatile Inhibition and Mycoparasitism.

Pathogenic root/wood rot fungal species infect multiple urban tree species in Singapore. There is a need for sustainable and environmentally friendly mitigation. We report the local strains as potential biocontrol agents (BCAs) for pathogenic wood rot fungal species such as , , and .

Corrigendum: Defeating Huanglongbing Pathogen Liberibacter asiaticus With Indigenous Citrus Endophyte L1-21.

[This corrects the article DOI: 10.3389/fpls.2021.

Defeating Huanglongbing Pathogen Liberibacter asiaticus With Indigenous Citrus Endophyte L1-21.

Huanglongbing (HLB) has turned into a devastating botanical pandemic of citrus crops, caused by Liberibacter asiaticus (Las). However, until now the disease has remained incurable with very limited control strategies available. Restoration of the affected microbiomes in the diseased host through the introduction of an indigenous endophyte L1-21 isolated from healthy citrus may provide an innovative approach for disease management.

Itraconazole Induces Regression of Infantile Hemangioma via Downregulation of the Platelet-Derived Growth Factor-D/PI3K/Akt/mTOR Pathway.

Infantile hemangioma is the most common benign vascular tumor of infancy. We have previously reported that itraconazole, a common antifungal agent, can clinically improve or cure infantile hemangioma; however, the underlying molecular mechanisms are still unclear. Here, we show that itraconazole treatment significantly inhibits proliferation and promotes apoptosis of the endothelial cells of mouse hemangioma cell line and infantile primary hemangioma endothelial cell.

Phenformin Enhances the Efficacy of ERK Inhibition in NF1-Mutant Melanoma.

Inactivation of the tumor suppressor neurofibromin 1 (NF1) presents a newly characterized melanoma subtype, for which currently no targeted therapies are clinically available. Preclinical studies suggest that extracellular signal-regulated kinase (ERK) inhibitors are likely to provide benefit, albeit with limited efficacy as a single agent; therefore, there is a need for rationally designed combination therapies. Here, we evaluate the combination of the ERK inhibitor SCH772984 and the biguanide phenformin.

Ecthyma gangrenosum and multiple nodules: cutaneous manifestations of Pseudomonas aeruginosa sepsis in a previously healthy infant.

Pseudomonas aeruginosa septicemia is rare in healthy children. Dermatologic manifestations, such as ecthyma gangrenosum and indurated erythematous nodular lesions, as the first signs of pseudomonas infection have rarely been reported. Herein we report a previously healthy 7-month-old girl with ecthyma gangrenosum and multiple nodules as the manifestations of P.