Mast cell activation is involved in stress-induced epithelial barrier dysfunction in the esophagus.

Objective: We aimed to investigate the role of mast cell in stress-induced barrier dysfunction in the esophagus and its possible pathway involved using mast cell-deficient (Ws/Ws) rats.

Methods: Ws/Ws rats and normal (+/+) rats were submitted to chronic restraint stress (CRS) 2 h/day for 7 days. Tissues were obtained from distal esophagus.

[Reconstitution of mast cell population in gastrointestinal tract by bone marrow transplantation in mast cell deficient rats].

Objective: To explore whether bone marrow transplantation (BMT) can restore gastrointestinal mast cells in mast cell deficient (Ws/Ws) rats and understand the features of these reconstituted mast cells.

Methods: Thirty-six Ws/Ws rats were subjected to Co(60) radiation at 6 gradient doses (6.0, 7.

2,2'-[4-Acetyl-1,3-phenyl-enebis(-oxy)]diacetic acid.

In the title compound, C12H12O7, the dihedral angles between the benzene ring and the mean planes of the 3-carb-oxy-meth-oxy, 1-carb-oxy-meth-oxy and acetyl substituents are 8.67 (7), 7.81 (6) and 10.

Essential role of mast cells in the visceral hyperalgesia induced by T. spiralis infection and stress in rats.

Mast cells (MCs) deficient rats (Ws/Ws) were used to investigate the roles of MCs in visceral hyperalgesia. Ws/Ws and wild control (+/+) rats were exposed to T. spiralis or submitted to acute cold restraint stress (ACRS).

Vesicular glutamate transporter-3 contributes to visceral hyperalgesia induced by Trichinella spiralis infection in rats.

Background: According to a recent study, vesicular glutamate transporter-3 (VGLUT3) contributes to injury-induced mechanical hyperalgesia in mice.

Aims: The aims of the study were to investigate whether VGLUT3 is involved in visceral pain, and whether transient intestinal infection or acute cold restraint stress (ACRS) affects VGLUT3 expression levels in rats.

Methods: Changes in VGLUT3 and c-Fos proteins were evaluated in rats which received noxious colorectal distension (CRD) stimulation.

(E)-1-(2,4-Dihy-droxy-phen-yl)-3-(4-hydroxy-phen-yl)prop-2-en-1-one monohydrate.

In the title compound, C(15)H(12)O(4)·H(2)O, the two benzene rings are not coplanar, making a dihedral angle of 7.24 (16)°. An intra-molecular hy-droxy-carbonyl O-H⋯O hydrogen bond occurs.