Construct Validity of a Simple Laparoscopic Ovarian Cystectomy Model Using a Validated Objective Structured Assessment of Technical Skills.

Study Objective: To determine the construct validity and interrater reliability of a laparoscopic ovarian cystectomy simulator using a global rating scale.

Design: Prospective blinded observational study (Canadian Task Force classification II.3).

Epithelioid sarcoma of the vulva and its clinical implication: A case report and review of the literature.

•We present a case of vulva epithelioid sarcoma, and review the articles.•The rarity of this disease causes delay in diagnosis and lack of guideline for optimal treatment.•Physicians should have high suspicions in diagnosing this vulvar disease using prompt biopsy without delay.

Staging Lymphadenectomy in Patients With Clear Cell Carcinoma of the Ovary.

Objective: The purpose of this study was to assess the rate of lymph node (LN) metastasis in comprehensively staged ovarian clear cell carcinoma (OCCC) clinically confined to the ovary and determine factors associated with LN metastasis.

Methods: We identified all cases of OCCC treated at 4 institutions from January 1994 through December 2011. We included cases with disease grossly confined to the ovary that had surgical staging performed, including at least 10 LNs sampled.

Gamma-ray-induced mutagen sensitivity and risk of sporadic breast cancer in young women: a case-control study.

Hypersensitivity to radiation exposure has been suggested to be a risk factor for the development of breast cancer. In this case-control study of 515 young women (≤ 55 years) with newly diagnosed sporadic breast cancer and 402 cancer-free controls, we examined the radiosensitivity as measured by the frequency of chromatid breaks induced by gamma-radiation exposure in the G2 phase of phytohemagglutinin-stimulated and short-term cultured fresh lymphocytes. We found that the average chromatid breaks per cell from 50 well-spread metaphases were statistically significantly higher in 403 non-Hispanic White breast cancer patients (0.

Polymorphisms in the SULF1 gene are associated with early age of onset and survival of ovarian cancer.

Background: SULF1 (sulfatase 1) selectively removes the 6-O-sulphate group from heparan sulfate, changing the binding sites for extracellular growth factors. SULF1 expression has been reported to be decreased in various cancers, including ovarian cancer. We hypothesized that single nucleotide polymorphisms (SNPs) of SULF1 would impact clinicopathologic characteristics.

Does the type of hysterectomy affect the prognosis in clinical stage I endometrial cancer?

Aim: To determine whether clinical outcomes show a benefit from extended hysterectomy in patients with early endometrial cancer.

Methods: We reviewed the medical records of 101 patients who had endometrial cancer with clinical stage I disease. All the patients were surgically staged, and two types of hysterectomy, simple hysterectomy (SH) or extended hysterectomy (EH), were performed by surgeon's preference.

Polymorphisms in the survivin promoter are associated with age of onset of ovarian cancer.

Survivin has been identified as an apoptosis inhibitor and a key regulator of mitosis. A common polymorphism (-31G>C) at the survivin promoter has been extensively studied in various cancers and reported to influence survivin expression. We hypothesize that polymorphisms in the survivin promoter are associated with clinical outcomes of patients with ovarian cancer.

The functional promoter polymorphism (-842G>C) in the PIN1 gene is associated with decreased risk of breast cancer in non-Hispanic white women 55 years and younger.

PIN1, an isomerase that causes conformational changes in proteins, plays an important role in mammary epithelial cell growth both physiologically and pathologically. Thus, genetic variants in the PIN1 gene may alter protein function and cancer risk. We have previously demonstrated an association between a PIN1 promoter variant (-842G>C; rs2233678) and risk of squamous cell carcinoma of the head and neck, a finding supported by additional functional data.

The increasing frequency of cervical cancer in Korean women under 35.

Purpose: The goal of this study was to determine the clinical and epidemiological trends of cervical cancer in young Korean women. Social behavior including sexual habits has changed in Korean women, with sexual activity commencing at a younger age. These changes are likely to influence certain risk factors of cervical cancer, resulting in changing trends in the occurrence of the disease.