Publications by authors named "Chan Gong"
Neuropathic pain (NP) is a complex and prevalent chronic pain condition that affects millions of individuals worldwide. Previous studies have shown that prior exercise protects against NP caused by nerve injury. However, the underlying mechanisms of this protective effect remain to be uncovered.
View Article and Find Full Text PDFChanges in DNA methylation and subsequent alterations in gene expression have opened a new direction in research related to the pathogenesis of peripheral neuropathic pain (PNP). This study aimed to reveal epigenetic perturbations underlying DNA methylation in the dorsal root ganglion (DRG) of rats with peripheral nerve injury in response to prior exercise and identify potential target genes involved. Male Sprague-Dawley rats were divided into three groups, namely, chronic constriction injury (CCI) of the sciatic nerve, CCI with prior 6-week swimming training (CCI_Ex), and sham operated (Sham).
View Article and Find Full Text PDFArticle Synopsis
- Exercise has been shown to help reduce neuropathic pain (NP) through various mechanisms, including inflammation and neurochemical changes.
- Neuroglia, which are cells that support and maintain neurons, play a significant role in the development of NP and can be influenced by exercise.
- The article aims to provide insights into how understanding neuroglia’s role can inform effective exercise treatment strategies for managing NP.
Article Synopsis
- Neuropathic pain, linked to neurological injuries and neurodegenerative diseases, significantly affects daily life, yet its study through bibliometrics is underexplored.
- Using CiteSpace and VOSviewer, researchers analyzed 387 studies from a larger pool, revealing that 85.27% of relevant papers were published from 2007-2022, with the U.S. leading in contributions.
- Key findings highlighted multiple sclerosis, Parkinson’s, and Alzheimer’s as the main focus areas, with microglia-regulated neuroinflammation emerging as an important research topic alongside treatments like deep brain stimulation and gamma knife radiosurgery.
Article Synopsis
- Neuropathic pain (NeuP) is difficult to treat, but recent research indicates that neuromodulation therapies can provide effective relief, leading to an increase in related publications.
- A bibliometric analysis of research from January 1994 to January 2023 identified 1404 relevant articles, highlighting that studies are growing steadily across 58 countries and 411 journals, with key contributions from Harvard and author J.P. Lefaucheur.
- Key research areas focus on various forms of stimulation, such as motor cortex and spinal cord stimulation, as well as understanding the underlying mechanisms, showing a rapid increase in interest over the past five years.
Objective: Neuropathic pain (NP) is a common disease that manifests with pathological changes in the somatosensory system. In recent years, the interactions of NP with the epigenetic mechanism have been increasingly elucidated. However, only a few studies have used bibliometric tools to systematically analyze knowledge in this field.
View Article and Find Full Text PDFBackground: Sequential administration of platinum-based doublet therapy and then a taxane may reduce the risk of drug resistance and, therefore, improve treatment outcome. This study was designed to evaluate the efficacy and tolerability of sequential administration of irinotecan and cisplatin and then docetaxel in patients with advanced non-small cell lung cancer (NSCLC).
Methods: Eligible patients received irinotecan in 60-mg/m2 infusions for 30 to 60 minutes on days 1, 8, and 15, and cisplatin in 75-mg/m2 infusions for 60 minutes on day 1 every 28 days for four cycles (IC).