Food-Away-From-Home Options in Local Military Nutrition Environments.

Introduction: Americans have increased their intake of food away from home, which is lower in quality and higher in calories than food prepared at home. The increase of operations that serve food also impacts the military nutrition environment-including all foods, beverages, and dietary supplements available to the military community-and its role in nutritional fitness.

Methods: As part of a pilot study, 5 military installations used the online Military Nutrition Environment Assessment Tool to evaluate their local food landscape.

Nanothermodynamics: There's Plenty of Room on the Inside.

Nanothermodynamics provides the theoretical foundation for understanding stable distributions of statistically independent subsystems inside larger systems. In this review, it is emphasized that extending ideas from nanothermodynamics to simplistic models improves agreement with the measured properties of many materials. Examples include non-classical critical scaling near ferromagnetic transitions, thermal and dynamic behavior near liquid-glass transitions, and the 1/-like noise in metal films and qubits.

Small and Simple Systems That Favor the Arrow of Time.

The 2nd law of thermodynamics yields an irreversible increase in entropy until thermal equilibrium is achieved. This irreversible increase is often assumed to require large and complex systems to emerge from the reversible microscopic laws of physics. We test this assumption using simulations and theory of a 1D ring of N Ising spins coupled to an explicit heat bath of N Einstein oscillators.

Social Fitness and the Social Domain: A Holistic Approach Based on Total Force Fitness.

The Total Force Fitness (TFF) framework was envisioned as a holistic framework of interrelated domains, whereby impact in one domain could have cascading implications for the others. For this reason, definitional clarity surrounding how to achieve fitness in the various domains is crucial. Social fitness definitions tend to focus on individual efforts and overlook the powerful impact of the social group and the social environment on the individual.

Critical Competencies of Military Embedded Health and Performance Professionals: The "Culture General" Approach.

Human performance teams (HPT) delivering a wide range of services within military unit communities serve as a model for advancing business practices in support of the 2018 National Defense Strategy. Relatively new, the demand for these embedded professionals continues to grow in response to its favorable proximity, community-based design, operationalized delivery system, and adaptive business practices. However, many civilian professionals come from diverse disciplines of specialties and experiences.

Bis-Cinnamamide Derivatives as APE/Ref-1 Inhibitors for the Treatment of Human Melanoma.

Human malignant melanoma exhibits imbalances in redox status, leading to activation of many redox-sensitive signaling pathways. APE/Ref-1 is a multifunctional protein that serves as a redox chaperone that regulates many nuclear transcription factors and is an important mechanism in cancer cell survival of oxidative stress. Previous studies showed that APE/Ref-1 is a potential druggable target for melanoma therapy.

Optimizing Teamwork for Human Performance Teams: Strategies for Enhancing Team Effectiveness.

Human performance teams (HPTs) are highly capable and complex teams comprised of medical and performance professionals dedicated to supporting health and sustaining mission capabilities of the Special Operations Forces (SOF) warfighter community. As resources continue to be devoted to recruiting, hiring, and organizing HPTs, there is an increased need to support team-based capabilities, or their ability to work collaboratively and cooperatively across boundaries. In this article, we draw on existing evidence-based approaches to supporting team-based competencies to present a set of strategies designed to address barriers to cross-boundary teaming, catalyze innovation and precision of human performance optimization (HPO) service delivery, and maximize the impact of HPTs on warfighter medical and mission readiness.

Optimizing Special Operations Forces Operator Talents and Mission Capabilities: Human Performance Optimization and Total Force Fitness Capability-Based Blueprint and Targeting System.

The Special Operations Forces (SOF) community represents an impressive degree of diversity in talents, culture, mission essential tasks, and occupational risk exposures across Service branches, their career fields, and units. Sustaining the capabilities of the SOF Operator across a career lifespan requires collaboratively addressing the current gap between medical readiness and mission readiness with support services and their SOF end users. Given the diverse needs of SOF Operators and their units, realigning performance and health (P&H) service delivery to meet their specific needs will require the adoption of an alternative business framework, operationally focused metrics, and retargeting to ensure SOF Operators are not just medically ready, but mission ready.

Human Performance Optimization: An Operational and Operator-Centric Approach.

USSOCOM invests millions of dollars in the assessment, selection, and training of its Operators. Handpicked and forged to defend their nation, each Operator emerges from initial and career field training with unique skills and honed talents integral to their unit's effectiveness, sustainability, and mission success. The need for SOF unit commanders to optimize and preserve the talents of their Operators was highlighted as a top priority in the 2018 National Defense Strategy.

Ultra-thin and strong formvar-based membranes with controlled porosity for micro- and nano-scale systems.

We present a methodology for developing ultra-thin and strong formvar-based membranes with controlled morphologies. Formvar is a thin hydrophilic and oleophilic polymer inert to most chemicals and resistant to radiation. The formvar-based membranes are viable materials as support structures in micro- and macro-scale systems depending on thinness and porosity control.

Solid-phase extraction microfluidic devices for matrix removal in trace element assay of actinide materials.

Advances in sample nebulization and injection technology have significantly reduced the volume of solution required for trace impurity analysis in plutonium and uranium materials. Correspondingly, we have designed and tested a novel chip-based microfluidic platform, containing a 100-µL or 20-µL solid-phase microextraction column, packed by centrifugation, which supports nuclear material mass and solution volume reductions of 90% or more compared to standard methods. Quantitative recovery of 28 trace elements in uranium was demonstrated using a UTEVA chromatographic resin column, and trace element recovery from thorium (a surrogate for plutonium) was similarly demonstrated using anion exchange resin AG MP-1.

Assessment of the Tumorigenic Potential of Spontaneously Immortalized and hTERT-Immortalized Cultured Dental Pulp Stem Cells.

Dental pulp stem cells (DPSCs) provide an exciting new avenue to study neurogenetic disorders. DPSCs are neural crest-derived cells with the ability to differentiate into numerous tissues including neurons. The therapeutic potential of stem cell-derived lines exposed to culturing ex vivo before reintroduction into patients could be limited if the cultured cells acquired tumorigenic potential.

Energy balance during underwater implosion of ductile metallic cylinders.

Energy-based metrics are developed and applied to a numerical test case of implosion of an underwater pressure vessel. The energy metrics provide estimates of the initial energy in the system (potential energy), the energy released into the fluid as a pressure pulse, the energy absorbed by the imploding structure, and the energy absorbed by air trapped within the imploding structure. The primary test case considered is the implosion of an aluminum cylinder [diameter: 2.

1/ f noise from the laws of thermodynamics for finite-size fluctuations.

Computer simulations of the Ising model exhibit white noise if thermal fluctuations are governed by Boltzmann's factor alone; whereas we find that the same model exhibits 1/f noise if Boltzmann's factor is extended to include local alignment entropy to all orders. We show that this nonlinear correction maintains maximum entropy during equilibrium fluctuations. Indeed, as with the usual way to resolve Gibbs' paradox that avoids entropy reduction during reversible processes, the correction yields the statistics of indistinguishable particles.

Optical and SPION-enhanced MR imaging shows that trans-stilbene inhibitors of NF-κB concomitantly lower Alzheimer's disease plaque formation and microglial activation in AβPP/PS-1 transgenic mouse brain.

Alzheimer's disease (AD) is associated with a microglia-dependent neuroinflammatory response against plaques containing the fibrous protein amyloid-β (Aβ). Activation of microglia, which closely associate with Aβ plaques, engenders the release of pro-inflammatory cytokines and the internalization of Aβ fibrils. Since the pro-inflammatory transcription factor NF-κB is one of the major regulators of Aβ-induced inflammation, we treated transgenic amyloid-β protein protein/presenilin-1 (AβPP/PS1) mice for one year with a low dose (0.

Modified Bose-Einstein and Fermi-Dirac statistics if excitations are localized on an intermediate length scale: applications to non-Debye specific heat.

Disordered systems show deviations from the standard Debye theory of specific heat at low temperatures. These deviations are often attributed to two-level systems of uncertain origin. We find that a source of excess specific heat comes from correlations between quanta of energy if excitations are localized on an intermediate length scale.

Large magnetoresistance of nickel-silicide nanowires: non-equilibrium heating of magnetically-coupled dangling bonds.

We demonstrate large (>100%) time-dependent magnetoresistance in nickel-silicide nanowires and develop a thermodynamic model for this behavior. The model describes nonequilibrium heating of localized spins in an increasing magnetic field. We find a strong interaction between spins but no long-range magnetic order.

Jet-launching structure resolved near the supermassive black hole in M87.

Approximately 10% of active galactic nuclei exhibit relativistic jets, which are powered by the accretion of matter onto supermassive black holes. Although the measured width profiles of such jets on large scales agree with theories of magnetic collimation, the predicted structure on accretion disk scales at the jet launch point has not been detected. We report radio interferometry observations, at a wavelength of 1.

DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction.

Recent successes in deriving human-induced pluripotent stem cells (hiPSCs) allow for the possibility of studying human neurons derived from patients with neurological diseases. Concomitant inhibition of the BMP and TGF-β1 branches of the TGF-β signaling pathways by the endogenous antagonist, Noggin, and the small molecule SB431542, respectively, induces efficient neuralization of hiPSCs, a method known as dual-SMAD inhibition. The use of small molecule inhibitors instead of their endogenous counterparts has several advantages including lower cost, consistent activity, and the maintenance of xeno-free culture conditions.

Hemoglobin levels in normal-weight and obese patients during pregnancy.

Objective: To determine if there is a difference in hemoglobin levels in normal-weight patients compared with obese women during the second trimester of pregnancy.

Study Design: This was a retrospective cohort study of hemoglobin levels in the second trimester of pregnancy from 2009 to 2010 in 46 primarily indigent patients (23 normal weight and 23 obese) using the current body mass index classification.

Results: There were no differences in demographic and baseline characteristics between the two study groups except for body mass index as expected (p < 0.

Ensemble-based computational approach discriminates functional activity of p53 cancer and rescue mutants.

The tumor suppressor protein p53 can lose its function upon single-point missense mutations in the core DNA-binding domain ("cancer mutants"). Activity can be restored by second-site suppressor mutations ("rescue mutants"). This paper relates the functional activity of p53 cancer and rescue mutants to their overall molecular dynamics (MD), without focusing on local structural details.

Dynamical characteristics of the giant magneto-resistance of epitaxial silicide nanowires.

We study the dynamical properties of a hugely hysteretic magneto-resistance in epitaxially formed silicide nanowires, and propose a model for this remarkable effect in which it is attributed to the collective interactions among interfacial spins associated with dangling bonds. According to our model, the dynamic character of this effect reflects a competitive tendency for the interfacial spins to align in different collective configurations (random, ordered, and multi-domain). Our work thus provides a dramatic demonstration of how the collective interactions among interfacial spins can modify the properties of nonmagnetic nanostructures.

Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal.

Hec1 is a conserved mitotic regulator critical for spindle checkpoint control, kinetochore functionality, and cell survival. Overexpression of Hec1 has been detected in a variety of human cancers and is linked to poor prognosis of primary breast cancers. Through a chemical genetic screening, we have identified a small molecule, N-(4-[2,4-dimethyl-phenyl]-thiazol-2-yl)-benzamide (INH1), which specifically disrupts the Hec1/Nek2 interaction via direct Hec1 binding.

Event-horizon-scale structure in the supermassive black hole candidate at the Galactic Centre.

The cores of most galaxies are thought to harbour supermassive black holes, which power galactic nuclei by converting the gravitational energy of accreting matter into radiation. Sagittarius A* (Sgr A*), the compact source of radio, infrared and X-ray emission at the centre of the Milky Way, is the closest example of this phenomenon, with an estimated black hole mass that is 4,000,000 times that of the Sun. A long-standing astronomical goal is to resolve structures in the innermost accretion flow surrounding Sgr A*, where strong gravitational fields will distort the appearance of radiation emitted near the black hole.