Publications by authors named "Chamalka Gimhani de Silva"
Article Synopsis
- This study aimed to analyze the protein profiles in skin lesions of patients with cutaneous leishmaniasis (CL) using mass spectrometry, revealing important biological insights.
- Eight lesion samples from CL patients were compared to healthy control biopsies, and significant protein differences were identified, with 67 proteins showing notable expression changes.
- The study highlighted the integrated endoplasmic reticulum stress response as a key pathway in CL lesions, validated by immunohistochemistry, suggesting complex immune and pathological processes in affected individuals.
Characterization of the host response in cutaneous leishmaniasis (CL) through proteome profiling has gained limited insights in leishmaniasis research, in comparison to that of the parasite. The primary objective of this study was to comprehensively analyze the proteomic profile of the skin lesions tissues in patients with CL, by mass spectrometry, and subsequent validation of these findings through immunohistochemical methods. Sixty-seven proteins exhibited significant differential expression between tissues of CL lesions and healthy controls (p<0.
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