Publications by authors named "Challen A Pretorius"
Gastroenterology
January 2025
Article Synopsis
- Gastric metaplasia, which can occur due to chronic inflammation from Helicobacter pylori (Hp) infection or autoimmune gastritis (AIG), raises the risk of developing gastric cancer.
- Research on mouse models and human tissues revealed that both Hp infection and AIG caused similar metaplastic changes, although some subtle differences in cell types were noted.
- A specific metaplastic subtype associated with cancer, indicated by the biomarker ANPEP/CD13, was found in both conditions, suggesting a shared risk for cancer and the potential for improved patient detection strategies.
