Smoking during pregnancy and postpartum among Tunisian women.

Objective: The validity of self-reported smoking in population surveys remains an important question yet to be answered. This has been of particular concern in a situation where there is a strong social pressure against pregnant and postpartum women. An associated question is what would be the value of measuring urinary cotinine concentrations in such surveys to obtain validated smoking data.

[Photosensitivity induced by metformin: a report of 3 cases].

Background: Metformin is an oral antihypoglycemic drug. Its cutaneous side effects are rare and photosensitivity had not been reported.

Aim: Case report.

Recurrent dysosmia induced by pyrazinamide.

Pyrazinamide can have adverse effects such as hepatic toxicity, hyperuricemia or digestive disorders. In rare cases, alterations in taste and smell function have been reported for pyrazinamide when combined with other drugs. We report a case of reversible olfactory disorder related to pyrazinamide in a woman, with a positive rechallenge.

An animal model of testicular toxicity by cyclosporine: evaluation and protection.

CyclosporineA (CsA) improves the survival of patients who benefited from transplantation. However, its use is generally limited by its side effects. The aim of our study was to measure, in an experimental model, the changes of the testosterone plasma levels after 21 days of CsA treatment and to explain the mechanism of this modification.

Orofacial dyskinesia associated with tiemonium.

Tiemonium, an anti-spasmodic drug, can have adverse effects related to its anti-muscarinic effect. Dyskinesia is described with other anti-cholinergic drugs, but there are no reports of dyskinesia associated with tiemonium. We report a reversible orofacial dyskinesia following tiemonium intake (contained in Viscéralgine forte) in a woman with positive rechallenge.

[Fixed drug eruption : about 13 cases].

Aim: To discuss, through a retrospective study, the epidemiological and clinical aspects and the causative agents of fixed drug eruption.

Methods: Thirteen cases were collected retrospectively during 11 years. There were 10 females and 3 males with a mean age of 44 years.

[Drug tendon disorders].

Tendinitis is a rare adverse reaction described after drugs use. It's described with drug belonging to the same class. Physiopathology is still unknown.

[Halothane-induced hepatitis. 8 case reports].

Halothane (Fluothane) is a halogenic volatile anaesthetic used in therapeutic since 1956. His adverse effects are generally moderate with the exception of hepatitis that is usually severe and sometimes fatal. In our study, we analyze 8 cases of halothane-induced hepatitis, notified in the Centre National de Pharmacovigilance between 1994 and 1999 and validate according to B.