Publications by authors named "Chakshu Walia"
Alzheimer's disease (AD) is a neurodegenerative condition that results in brain shrinkage and the death of brain cells. The search for new treatment agents with many targets is now crucial due to the insufficient effectiveness, and adverse effects, including pharmacokinetic issues of traditional AD medications. Although phytochemicals have anti-disease characteristics and thus are widely used and accepted by people, researchers have also determined some of their most beneficial functions.
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- Parkinson's disease (PD) is linked to increased levels of alpha-synuclein proteins due to elevated expression of the SNCA gene, which leads to motor and cognitive decline.
- Non-coding RNAs (lncRNAs, miRNAs, and siRNAs) play significant roles in regulating SNCA expression and alpha-synuclein aggregation, influencing the disease's progress.
- The review suggests that targeting these small RNAs could open new avenues for developing therapeutic interventions to reduce alpha-synuclein accumulation in PD.