Evaluating the Effectiveness of a Comprehensive Interventional Package on the Quality of Life of Children With Asthma.

Introduction: Asthma is a chronic lung disease that negatively affects children's quality of life (QoL). Improving QoL is a key outcome in managing children with asthma.

Objectives: The objective of the study was to evaluate the effectiveness of a comprehensive interventional package on QoL among asthmatic children attending an asthma clinic at a selected hospital.

Role of prophylactic intravenous calcium in prevention of postspinal hypotension among women with preeclampsia undergoing cesarean delivery: a placebo controlled randomized clinical trial.

Background: Preeclamptic women, in addition to traditional antihypertensive medications, often receive magnesium supplementation and are at increased risk of postspinal hypotension Postspinal hypotension increases the risk of fetomaternal morbidity. Calcium is a physiological antagonist of magnesium in vascular smooth muscle. Therefore, the study hypothesized that calcium is better suited for preserving systemic vascular resistance and preventing postspinal hypotension during cesarean delivery.

Lower-intensity CPX-351 plus venetoclax induction for adults with newly diagnosed AML unfit for intensive chemotherapy.

Preclinical data suggest a rationale for combining CPX-351, a dual-drug liposomal encapsulation of daunorubicin and cytarabine, with venetoclax, a B-cell lymphoma-2 inhibitor. This phase 1b study evaluated lower-intensity CPX-351 combined with venetoclax in adults with acute myeloid leukemia (AML) considered unfit/ineligible for intensive chemotherapy. In a dose-exploration phase using a 3+3 design, patients received stepwise dosing of CPX-351 IV on days 1 and 3 plus venetoclax 400 mg orally on days 2 to 21 per cycle to determine the recommended phase 2 dose (RP2D) for this combination.

Effectiveness of Lidocaine versus Lidocaine with Magnesium Sulphate During Inferior Alveolar Nerve Block in Patients with Symptomatic Irreversible Pulpitis: A Randomised Double-Blinded Clinical Trial.

Objective: This study aimed to compare the effectiveness of lidocaine with magnesium sulphate in patients undergoing root canal treatment following irreversible pulpitis.

Methods: A total of 86 patients were randomised to receive 1.8 ml of 2% lidocaine replaced with 0.

The efficient application of instilling negative pressure wound therapy with a hypochlorous acid-preserved wound cleanser: a case series and practical advice.

Background: The use of negative pressure wound therapy with instillation and dwell time (NPWTi-d) has been shown to be effective in removing nonviable tissue, reducing bioburden, and promoting granulation tissue formation in acute and chronic infected wounds.

Objective: To illustrate the clinical efficacy of the use of pure hypochlorous acid (pHA) antimicrobially preserved wound cleansing solution as the instillation fluid for NPWTi-d (NPWTi-d/pHA) in wound bed preparation in patients with complex wounds.

Case Report: The treatment protocol for use of NPWTi-d/pHA in preparing wound beds for final closure is demonstrated in 3 illustrative cases of patients with complex wounds resulting from necrotizing infection and trauma with heavy contamination.

Biomechanical Properties of Maxillary Second Molar with Different Endodontic Cavity Designs - A Finite Element Analysis.

Aim: To evaluate the biomechanical properties of maxillary second molars with three different cavity designs - Traditional, Conservative, and Extended - endodontic cavities using the finite element analysis method.

Materials And Methods: Three finite element models of a maxillary second molar with three different types of endodontic cavities were designed and restored. Each model was subjected to three different force loads directed at the occlusal surface.

Time and labor costs of compression therapy wrap system for lower extremity edema: results from a single center.

Introduction: Compression therapy is the standard of care for the treatment of lower extremity edema. However, compression therapy systems can be time-consuming to apply, which adds costs to the health care system and further strains human resources.

Objective: The purpose of this study was to assess time and labor costs associated with the application of a 2LB versus 4LB compression therapy system.

Evidence for 2-Methoxyestradiol-Mediated Inhibition of Receptor Tyrosine Kinase RON in the Management of Prostate Cancer.

2-Methoxyestradiol (2-ME) possesses anti-tumorigenic activities in multiple tumor models with acceptable tolerability profile in humans. Incomplete understanding of the mechanism has hindered its development as an anti-tumorigenic compound. We have identified for the first-time macrophage stimulatory protein 1 receptor (MST1R) as a potential target of 2-ME in prostate cancer cells.

Palmatine suppresses glutamine-mediated interaction between pancreatic cancer and stellate cells through simultaneous inhibition of survivin and COL1A1.

Reciprocal interaction between pancreatic stellate cells (PSCs) and cancer cells (PCCs) in the tumor microenvironment (TME) promotes tumor cell survival and progression to lethal, therapeutically resistant pancreatic cancer. The goal of this study was to test the ability of Palmatine (PMT) to disrupt this reciprocal interaction in vitro and examine the underlying mechanism of interaction. We show that PSCs secrete glutamine into the extracellular environment under nutrient deprivation.

Pancreatic cancer: Current status and Challenges.

Purpose Of The Review: The 5-year survival rate of patients with pancreatic cancer (PanCA) has remained stagnant. Unfortunately, the incidence is almost equal to mortality rates. These facts underscore the importance of concerted efforts to understand the pathology of this disease.

Management of Moisture-Associated Skin Damage: A Scoping Review.

Background: Protecting the skin against moisture-associated damage is an important component of comprehensive skin and wound care. Based on a review of literature, the authors propose key interventions to protect and prevent damage in the skin folds, perineum, and areas surrounding a wound or stoma.

Objective: The aim of this scoping review is to identify and provide a narrative integration of the existing evidence related to the management and prevention of moisture-associated skin damage (MASD).

The Compatibility of Chlorhexidine and a Skin Care Product Line: A Real-World Analysis of Hospital-Acquired Infection Rates.

Chlorhexidine gluconate (CHG) use helps reduce hospital-acquired infections (HAIs). Chlorhexidine gluconate effectiveness can be reduced by use of skin care products. Although laboratory work can be performed to prove compatibility, such work has limitations.

Evaluation of a bovine 100% native collagen for the treatment of chronic wounds: a case series.

Purpose: The roles of debridement, infection control, and moisture balance in wound healing are familiar to wound care clinicians, but these measures may not be sufficient for wound closure in all patients. In these cases, adjuvant therapies such as collagen dressings may be needed. Collagen dressings are thought to encourage wound healing by laying down a provisional biomaterial matrix that captures wound exudates because of its absorbent nature, and thus creates an environment necessary for healing.

Skin care product evaluation in a group of critically ill, premature neonates: a descriptive study.

Purpose: Cleansing, moisturizing, and protecting neonatal skin is important, but literature evaluating specific product lines is limited. The purpose of this study was to measure the influence of a skin care product line on overall skin condition, perineal erythema, and pain when applied to neonates in a neonatal intensive care unit (NICU).

Design: This was an open label, descriptive study.

A Single Long-Term Acute Care Hospital Experience with a Pressure Ulcer Prevention Program.

Purpose: The occurrence of pressure ulcers (PrUs) challenges care facilities. Few studies report PrU reduction efforts in long-term acute care (LTAC). This study described the PrU reduction efforts of a single, LTAC facility using the Medline Pressure Ulcer Prevention Program (mPUPP).

A laboratory comparison between two liquid skin barrier products.

Exposure of skin to friction and moisture is detrimental to skin health. The purpose of this experimental study was to investigate the ability of a cyanoacrylate polymer film to protect human skin against moisture and abrasion. A secondary purpose of this study was to compare this cyanoacrylate material to a traditional barrier film.

The Use of a Pure Native Collagen Dressing for Wound Bed Preparation Prior to Use of a Living Bi-layered Skin Substitute.

Management of chronic wounds in the outpatient setting is quite challenging. The extensive co-morbid medical problems of the chronically ill patient along with the complexities of the wound bed and its biochemical environment has led to a plethora of patients with poor wound healing. This ever increasing population is a challenge for the wound care practitioner and cost to the health care system and patient.

A controlled laboratory comparison of 4 topical skin creams moisturizing capability on human subjects.

Purpose: This study compares human skin capacitance (moisture) readings after the application of 4 different, commercially available, topical skin creams.

Subjects And Setting: Twenty-one subjects (15 women and 6 men) aged 49.38 ± 11.