Redox-Active Triphenylamine-Triazine Covalent Organic Framework: A High Surface Area Microporous Material for Electrochromism and Electrofluorochromism.

Porous covalent organic frameworks (COFs) offer significant advantages in electrochromic (EC) applications due to their high surface area and porosity, which facilitate faradaic redox-mediated diffusion-controlled processes. However, COFs remain underexplored as EC materials due to challenges such as limited solubility and poor film-forming ability. In this study, we synthesized a redox-active triphenylamine-containing COF (TPA-TCIF) on ITO glass via a solvothermal method tailored for electrochromism and electrofluorochromism.

Prompt engineering-enabled LLM or MLLM and instigative bioinformatics pave the way to identify and characterize the significant SARS-CoV-2 antibody escape mutations.

The research aims to identify and characterize the antibody escape mutations of NTD and RBD regions of SARS-CoV-2 using prompt engineering-enabled combined LLMs (large language models) and instigative bioinformatics techniques. We used two LLMs (ChatGPT and Mistral 7B) and one MLLM (Gemini model) to retrieve the significant NTD and RBD mutations. The retrieved significant mutations were characterized through the in silico servers.

The dual role of toll-like receptors in COVID-19: Balancing protective immunity and immunopathogenesis.

Toll-like receptors (TLRs) of human are considered as the most critical immunological mediators of inflammatory pathogenesis of COVID-19. These immunoregulatory glycoproteins are located on the surface and/or intracellular compartment act as innate immune sensors. Upon binding with distinct SARS-CoV-2 ligand(s), TLRs signal activation of different transcription factors that induce expression of the proinflammatory mediators that collectively induce 'cytokine storm'.

Mapping the Potential Genes and Associated Pathways Involved in Long COVID-Associated Brain Fog Using Integrative Bioinformatics and Systems Biology Strategy.

One of the recent emerging global health issues is long COVID. Among long COVID patients, long COVID-associated brain fog is an important area. We noted an immense gap in understanding the genes and associated pathways involved in long COVID-associated brain fog.

CAD-PsorNet: deep transfer learning for computer-assisted diagnosis of skin psoriasis.

Psoriasis, being a chronic, inflammatory, lifelong skin disorder, has become a major threat to the human population. The precise and effective diagnosis of psoriasis continues to be difficult for clinicians due to its varied nature. In northern India, the prevalence of psoriasis among adult population ranges from 0.

Large language model to multimodal large language model: A journey to shape the biological macromolecules to biological sciences and medicine.

After ChatGPT was released, large language models (LLMs) became more popular. Academicians use ChatGPT or LLM models for different purposes, and the use of ChatGPT or LLM is increasing from medical science to diversified areas. Recently, the multimodal LLM (MLLM) has also become popular.

Public-engagement strategies of the South Asian COVID-19 Task Force: The role of racialized healthcare workers in COVID-19 mitigation in Ontario.

The COVID-19 pandemic began in late 2019 and its uneven impact across different communities globally was quickly evident. In Canada, South Asian communities were disproportionately affected. In response, the South Asian COVID-19 Task Force (SACTF) emerged, seeking to address the unique challenges faced by the South Asian community.

Harnessing Biomolecule-Infused 2D Multi-layered Luminescent Zn(II) Coordination Polymer for Electrochemical Energy Storage.

Selecting the right functional linkers and metal centers is crucial for creating multifunctional crystalline coordination polymers, which show promise in energy storage applications. Herein, a new two-dimensional Zn(II)-based CP, named , has been synthesized using solvothermal methods with 2-amino terephthalic acid (2ATA) and the biomolecule purine as key building blocks. Purine, which is relatively unexplored in CP synthesis, plays a crucial role in the distinct properties of CPs.

Autoantibodies in COVID-19 and Other Viral Diseases: Molecular, Cellular, and Clinical Perspectives.

Autoantibodies are immune system-produced antibodies that wrongly target the body's cells and tissues for attack. The COVID-19 pandemic has made it possible to link autoantibodies to both the severity of pathogenic infection and the emergence of several autoimmune diseases after recovery from the infection. An overview of autoimmune disorders and the function of autoantibodies in COVID-19 and other infectious diseases are discussed in this review article.

Evolution and mutational landscape of highly pathogenic avian influenza strain A(H5N1) in the current outbreak in the USA and global landscape.

The emergence of highly pathogenic avian influenza strain A (H5N1) in the USA is a high concern. Here, we illustrated the evolution, divergence, transmission pattern, infection pattern, entropy diversity, nucleotide diversity, and mutational landscape of HPAI(H5N1). We depicted three phylogenetic trees, i.

The changing scenario of drug discovery using AI to deep learning: Recent advancement, success stories, collaborations, and challenges.

Due to the transformation of artificial intelligence (AI) tools and technologies, AI-driven drug discovery has come to the forefront. It reduces the time and expenditure. Due to these advantages, pharmaceutical industries are concentrating on AI-driven drug discovery.

Recent Advances in Immunological Landscape and Immunotherapeutic Agent of Nipah Virus Infection.

Over the last two decades, the Nipah virus (NiV) emerged as a highly lethal zoonotic pathogen to humans. Outbreaks occurred occasionally in South and Southeast Asia. Therefore, a safe and effective vaccine against the virus is needed to fight against the deadly virus.

Therapeutic Potential of Quercetin as an Antioxidant for Bone-Muscle-Tendon Regeneration and Aging.

Quercetin (QC), a naturally occurring bioflavonoid found in various fruits and vegetables, possesses many potential health benefits, primarily attributed to its robust antioxidant properties. The generation of oxidative stress in bone cells is a key modulator of their physiological behavior. Moreover, oxidative stress status influences the pathophysiology of mineralized tissues.

Molecular beam epitaxy and other large-scale methods for producing monolayer transition metal dichalcogenides.

Transition metal dichalcogenide (TMD/TMDC) monolayers have gained considerable attention in recent years for their unique properties. Some of these properties include direct bandgap emission and strong mechanical and electronic properties. For these reasons, monolayer TMDs have been considered a promising material for next-generation quantum technologies and optoelectronic devices.

Shape-tunable two-dimensional assemblies from chromophore-conjugated crystallizable poly(L-lactides) with chain-length-dependent photophysical properties.

This work reports temperature-dependent shape-changeable two-dimensional (2D) nanostructures by crystallization-driven self-assembly (CDSA) from a chromophore-conjugated poly(L-lactide) (PLLA) homopolymer (PTZ-P1) that contained a polar dye, phenothiazine (PTZ), at the chain-end of the crystallizable PLLA. The CDSA of PTZ-P1 in a polar solvent, isopropanol (iPrOH), by an uncontrolled heating-cooling process, majorly generates lozenge-shaped 2D platelets chain-folding-mediated crystallization of the PLLA core, leading to the display of the phenothiazines on the 2D surface that confers colloidal stability and orange-emitting luminescent properties to the crystal lamellae. Isothermal crystallization at 60 °C causes a morphological change in PTZ-P1 platelets from lozenge to truncated-lozenge to perfect hexagon under different annealing times, while no shape change was noticed in the structurally similar PTZ-P2 polymer with a longer PLLA chain under similar conditions.

Venetoclax resistance leads to broad resistance to standard-of-care anti-MM agents, but not to immunotherapies.

To our knowledge, venetoclax is the first example of personalized medicine for multiple myeloma (MM), with meaningful clinical activity as a monotherapy and in combination in patients with myeloma harboring the t(11:14) translocation. However, despite the high response rates and prolonged progression-free survival, a significant proportion of patients eventually relapse. Here, we aim to study adaptive molecular responses after the acquisition of venetoclax resistance in sensitive t(11:14) MM cell models.

Reverse Zoonotic Transmission of SARS-CoV-2 and Monkeypox Virus: A Comprehensive Review.

Reverse zoonosis reveals the process of transmission of a pathogen through the human-animal interface and the spillback of the zoonotic pathogen. In this article, we methodically demonstrate various aspects of reverse zoonosis, with a comprehensive discussion of SARS-CoV-2 and MPXV reverse zoonosis. First, different components of reverse zoonosis, such as humans, different pathogens, and numerous animals (poultry, livestock, pets, wild animals, and zoo animals), have been demonstrated.

Expression analysis and mapping of Viral-Host Protein interactions of Poxviridae suggests a lead candidate molecule targeting Mpox.

Background: Monkeypox (Mpox) is an important human pathogen without etiological treatment. A viral-host interactome study may advance our understanding of molecular pathogenesis and lead to the discovery of suitable therapeutic targets.

Methods: GEO Expression datasets characterizing mRNA profile changes in different host responses to poxviruses were analyzed for shared pathway identification, and then, the Protein-protein interaction (PPI) maps were built.